An exemplary system can be provide for facilitating electrophysiological recording and/or stimulation. The exemplary system can comprise a wireless neural interface device that can include a complementary metal-oxide-semiconductor (CMOS) integrated circuit. A flexible printed circuit board can also be provided with the system that can include a plurality of electrodes coupled to the CMOS integrated circuit. In addition, an exemplary method can be provided for manufacturing a wireless neural interface device for an electrical stimulation. According to such exemplary method, it is possible to provide a complementary metal-oxide-semiconductor (CMOS) integrated circuit that is mechanically flexible by being thinned. Further, it is possible to provide a flexible printed circuit board containing a plurality of electrodes. Then, it is possible to couple the flexible printed circuit board to the CMOS integrated circuit.

An exemplary system can be provide for facilitating electrophysiological recording and/or stimulation. The exemplary system can comprise a wireless neural interface device that can include a complementary metal-oxide-semiconductor (CMOS) integrated circuit. A flexible printed circuit board can also be provided with the system that can include a plurality of electrodes coupled to the CMOS integrated circuit. In addition, an exemplary method can be provided for manufacturing a wireless neural interface device for an electrical stimulation. According to such exemplary method, it is possible to provide a complementary metal-oxide-semiconductor (CMOS) integrated circuit that is mechanically flexible by being thinned. Further, it is possible to provide a flexible printed circuit board containing a plurality of electrodes. Then, it is possible to couple the flexible printed circuit board to the CMOS integrated circuit.

Embodiments of the present disclosure provide methods and systems for mapping colonic and rectal activity with an electrode array patch disposed over an abdomen skin surface of a patient. The method includes non-invasively measuring electrical signals associated with colonic activity of the patient with the electrode array patch over a predetermined time period, receiving the measured electrical signals from the electrode array patch over the predetermined time period, determining one or more abnormal cyclic motor patterns (CMPs) and/or abnormal high amplitude propagated contractions (HAPCs) based at least in part on the received measured electrical signals, and generating a report comprising at least the determination of the one or more abnormal CMPs and/or abnormal HAPCs.

Embodiments of the present disclosure provide methods and systems for mapping colonic and rectal activity with an electrode array patch disposed over an abdomen skin surface of a patient. The method includes non-invasively measuring electrical signals associated with colonic activity of the patient with the electrode array patch over a predetermined time period, receiving the measured electrical signals from the electrode array patch over the predetermined time period, determining one or more abnormal cyclic motor patterns (CMPs) and/or abnormal high amplitude propagated contractions (HAPCs) based at least in part on the received measured electrical signals, and generating a report comprising at least the determination of the one or more abnormal CMPs and/or abnormal HAPCs.

A front-end device is arranged to amplify an electric signal from an associated sensor, e.g. for amplifying an electric signal from a neural activity sensor. The front-end device has an amplifier circuit connected between its input and output terminals (Vin, Vout), wherein the amplifier circuit comprises a capacitive-coupled chopper circuit comprising a first gain element and first, second and third chopper switches arranged for operating at a chopper frequency. Further, the amplifier circuit has A) an impedance boosting auxiliary path connected to the input terminal in parallel with a first chopper switch of the CCC, wherein the impedance boosting auxiliary path comprises a pre-charging buffer, and B) a second gain element connected in a feedback path of the CCC. Such front-end device has high input impedance, and the input impedance is uncorrelated with the gain. It is highly suited for implantable micro devices, e.g. brain dusts.

The present application relates to an electrophysiologically based Spectro-Temporal Modulation (STM) test unit. The STM test unit comprises an STM stimulus generating unit, an output unit, wherein the STM stimulus generating unit is configured to provide STM test stimuli comprising at least one STM probe stimulus to a user via the output unit according to a predetermined STM test protocol. The STM test unit further comprises one or more electrodes for measuring electrophysiological responses of the user, and an analysis unit configured to analyse the recorded electrophysiological responses of the user measured in response to the provided stimuli. The present application further relates to a method of electrophysiologically based STM testing of a user.

The present application relates to an electrophysiologically based Spectro-Temporal Modulation (STM) test unit. The STM test unit comprises an STM stimulus generating unit, an output unit, wherein the STM stimulus generating unit is configured to provide STM test stimuli comprising at least one STM probe stimulus to a user via the output unit according to a predetermined STM test protocol. The STM test unit further comprises one or more electrodes for measuring electrophysiological responses of the user, and an analysis unit configured to analyse the recorded electrophysiological responses of the user measured in response to the provided stimuli. The present application further relates to a method of electrophysiologically based STM testing of a user.

The present disclosure relates to a linear flexible electrode for a peripheral nerve and a manufacturing method thereof. A linear flexible electrode for a peripheral nerve is provided, wherein the flexible electrode includes an implantation portion and a fixing portion, wherein at least part of the implantation portion is implantable into a peripheral nerve bundle, and the fixing portion is configured to fix the flexible electrode to the peripheral nerve bundle or other tissues in the vicinity of the peripheral nerve bundle, wherein: the flexible electrode includes a first insulation layer, a second insulation layer and a wire layer between the first insulation layer and the second insulation layer; and the implantation portion includes one or more electrode sites, each electrode site is electrically coupled to one of the wires in the wire layer, and in contact with the peripheral nerve after the flexible electrode is implanted into the peripheral nerve bundle to collect electrical signals from the peripheral nerve and transmit the collected electrical signals through the wires, or apply received electrical signals through the wires to the peripheral nerve.

The present disclosure relates to a linear flexible electrode for a peripheral nerve and a manufacturing method thereof. A linear flexible electrode for a peripheral nerve is provided, wherein the flexible electrode includes an implantation portion and a fixing portion, wherein at least part of the implantation portion is implantable into a peripheral nerve bundle, and the fixing portion is configured to fix the flexible electrode to the peripheral nerve bundle or other tissues in the vicinity of the peripheral nerve bundle, wherein: the flexible electrode includes a first insulation layer, a second insulation layer and a wire layer between the first insulation layer and the second insulation layer; and the implantation portion includes one or more electrode sites, each electrode site is electrically coupled to one of the wires in the wire layer, and in contact with the peripheral nerve after the flexible electrode is implanted into the peripheral nerve bundle to collect electrical signals from the peripheral nerve and transmit the collected electrical signals through the wires, or apply received electrical signals through the wires to the peripheral nerve.

A method of controlling operation of a neurostimulation device comprises receiving, by the neurostimulation device, an indication of a physiological search area of a subject for delivering electrical neurostimulation and a prioritized search list of neurostimulation parameters for neurostimulation therapy delivered to the search area; delivering the neurostimulation therapy to the search area and varying the neurostimulation parameters according to the parameter priority, wherein a highest priority parameter is varied first while lower priority parameters are held constant; determining the optimum value of the highest priority parameter; delivering neurostimulation to the search area using the determined optimum value of the highest priority parameter and varying one or more lower priority parameters according to the parameter priority; and determining optimum lower priority parameters for the neurostimulation.