A method of controlling operation of a neurostimulation device comprises receiving, by the neurostimulation device, an indication of a physiological search area of a subject for delivering electrical neurostimulation and a prioritized search list of neurostimulation parameters for neurostimulation therapy delivered to the search area; delivering the neurostimulation therapy to the search area and varying the neurostimulation parameters according to the parameter priority, wherein a highest priority parameter is varied first while lower priority parameters are held constant; determining the optimum value of the highest priority parameter; delivering neurostimulation to the search area using the determined optimum value of the highest priority parameter and varying one or more lower priority parameters according to the parameter priority; and determining optimum lower priority parameters for the neurostimulation.

A multi-electrode array device (1) comprises a substrate (10) having a substrate body (100), and a multiplicity of electrodes formed by a multiplicity of needle elements (120) arranged on said substrate body (100) and spaced with respect to each other along a plane (P). The needle elements (120) are formed from a metal layer (12) arranged on said substrate body (100), each needle element (120) comprising a contact section (121) extending along said plane (P) and a needle section (122) extending from said contact section (121) and having a tip (123), wherein said needle section (122) is bent with respect to said contact section (121) such that the needle section (122) with its tip (123) protrudes from said plane (P).

A multi-electrode array device (1) comprises a substrate (10) having a substrate body (100), and a multiplicity of electrodes formed by a multiplicity of needle elements (120) arranged on said substrate body (100) and spaced with respect to each other along a plane (P). The needle elements (120) are formed from a metal layer (12) arranged on said substrate body (100), each needle element (120) comprising a contact section (121) extending along said plane (P) and a needle section (122) extending from said contact section (121) and having a tip (123), wherein said needle section (122) is bent with respect to said contact section (121) such that the needle section (122) with its tip (123) protrudes from said plane (P).

A bioelectrode and a method for producing the bioelectrode are provided. The bioelectrode has a non-complicated structure, satisfactory elasticity, and is capable of preventing an increase of contact impedance due to an increase of the number of times of usage. The bioelectrode includes a support member, which is an electrically conductive member, and at least one electrode member, which is a member projecting from the support member. At least the electrode member is molded from an electrically conductive rubber containing a silicone rubber and treated metal particles containing a crosslinkable functional group on a surface thereof.

Described herein are systems and methods for calibrating dry electrode bioelectrical impedance measurements. These method and apparatuses may be used for sensing bioelectrical impedance for ambulatory and or long-term measurements. Calibration of bioelectrical impedance sensing may be performed by using measurements taken during a shorted configuration of the apparatus, in which the same current is applied to both the source and sink stimulation electrodes, to modify measurements taken in a forward and/or reverse configuration in which current is applied to either the source and/or sink.

A method of performing a neurovascular procedure includes the steps of providing an access assembly comprising a guidewire, access catheter and guide catheter; coupling the access assembly to a robotic drive system; and driving the access assembly to achieve supra-aortic vessel access. The guide wire and the access catheter are decoupled from the access assembly. A procedure assembly includes at least a guidewire and a procedure catheter. The procedure assembly is coupled to the robotic drive system; and used to perform a neurovascular procedure.

A catheter for electrophysiology includes a shaft extending along a longitudinal axis to a distal end and an end effector coupled to the distal end of the shaft. The end effector includes a first loop member disposed on a first side of the longitudinal axis, a second loop member disposed on a second side of the longitudinal axis, and a third loop member. The third loop member includes a first spine disposed on the first side of the longitudinal axis. The first spine includes a first plurality of electrodes. The first spine is positioned radially outwardly of the first loop member relative to the longitudinal axis. The third loop member further includes a second spine disposed on the second side of the longitudinal axis. The second spine includes a second plurality of electrodes and is positioned radially outwardly of the second loop member relative to the longitudinal axis.

A catheter for electrophysiology includes a shaft extending along a longitudinal axis to a distal end and an end effector coupled to the distal end of the shaft. The end effector includes a first loop member disposed on a first side of the longitudinal axis, a second loop member disposed on a second side of the longitudinal axis, and a third loop member. The third loop member includes a first spine disposed on the first side of the longitudinal axis. The first spine includes a first plurality of electrodes. The first spine is positioned radially outwardly of the first loop member relative to the longitudinal axis. The third loop member further includes a second spine disposed on the second side of the longitudinal axis. The second spine includes a second plurality of electrodes and is positioned radially outwardly of the second loop member relative to the longitudinal axis.

A method of controlling operation of a neurostimulation device comprises receiving, by the neurostimulation device, an indication of a physiological search area of a subject for delivering electrical neurostimulation and a prioritized search list of neurostimulation parameters for neurostimulation therapy delivered to the search area; delivering the neurostimulation therapy to the search area and varying the neurostimulation parameters according to the parameter priority, wherein a highest priority parameter is varied first while lower priority parameters are held constant; determining the optimum value of the highest priority parameter; delivering neurostimulation to the search area using the determined optimum value of the highest priority parameter and varying one or more lower priority parameters according to the parameter priority; and determining optimum lower priority parameters for the neurostimulation.

A method of controlling operation of a neurostimulation device comprises receiving, by the neurostimulation device, an indication of a physiological search area of a subject for delivering electrical neurostimulation and a prioritized search list of neurostimulation parameters for neurostimulation therapy delivered to the search area; delivering the neurostimulation therapy to the search area and varying the neurostimulation parameters according to the parameter priority, wherein a highest priority parameter is varied first while lower priority parameters are held constant; determining the optimum value of the highest priority parameter; delivering neurostimulation to the search area using the determined optimum value of the highest priority parameter and varying one or more lower priority parameters according to the parameter priority; and determining optimum lower priority parameters for the neurostimulation.