Certain embodiments described herein relate to a system for use in analyzing neural activity of nerves surrounding a biological lumen. The system includes a probe body, electrodes, a stimulator, and an amplifier. The stimulator delivers electrical stimulation via a first pair of the electrodes, supported by the probe body, to test for an evoked neural response by nerves surrounding the biological lumen. The amplifier includes a pair of input terminals, an output terminal, and a ground reference terminal. A second pair of the electrodes is electrically coupled to the pair of input terminals of the amplifier, to thereby enable the amplifier to produce the sensed signal indicative of the evoked neural response. A remaining one of the electrodes, which is not included in the first and the second pairs of the electrodes, is electrically coupled to the ground reference terminal of the amplifier.

Systems, apparatuses, and methods for electroporation ablation therapy are disclosed, with a protection device for protecting electronic circuitry, devices, and/or other components from induced currents and voltages generated during a cardiac ablation procedure. A system can include an ablation device near cardiac tissue of a heart. The system can further include a signal generator configured to generate a pulse waveform, where the signal generator coupled to the ablation device and configured to repeatedly deliver the pulse waveform to the ablation device in synchrony with a set of cardiac cycles of the heart. The system can further include a protection device configured to suppress induced current and voltage in an electronic device coupled to the protection device.

Systems, apparatuses, and methods for electroporation ablation therapy are disclosed, with a protection device for protecting electronic circuitry, devices, and/or other components from induced currents and voltages generated during a cardiac ablation procedure. A system can include an ablation device near cardiac tissue of a heart. The system can further include a signal generator configured to generate a pulse waveform, where the signal generator coupled to the ablation device and configured to repeatedly deliver the pulse waveform to the ablation device in synchrony with a set of cardiac cycles of the heart. The system can further include a protection device configured to suppress induced current and voltage in an electronic device coupled to the protection device.

An ambulatory cardiac device for improving a signal to noise profile of an electrocardiogram (ECG) signal of a patient is provided. The ambulatory cardiac device includes a plurality of active ECG electrodes disposed in a plurality of locations about a patient. Each active electrode can include an ECG electrode substrate configured to be in physical contact with skin of the patient, a local biasing substrate proximate to the ECG electrode substrate and configured to be in physical contact with the skin of the patient, and local biasing circuitry configured to provide a local biasing signal into a body of the patient via the local biasing substrate.

An ambulatory cardiac device for improving a signal to noise profile of an electrocardiogram (ECG) signal of a patient is provided. The ambulatory cardiac device includes a plurality of active ECG electrodes disposed in a plurality of locations about a patient. Each active electrode can include an ECG electrode substrate configured to be in physical contact with skin of the patient, a local biasing substrate proximate to the ECG electrode substrate and configured to be in physical contact with the skin of the patient, and local biasing circuitry configured to provide a local biasing signal into a body of the patient via the local biasing substrate.

An interference signal measuring facility is in a differential voltage measuring system with a signal measuring circuit for measuring bioelectric signals with a number of useful signal paths, each with a sensor electrode. In an embodiment, the interference signal measuring facility has an additional sensor lead for each sensor electrode each of which is electrically connected to a ground connection of a supply lead of a sensor electrode; and a measuring amplifier circuit, for each sensor electrode connected to the additional sensor lead via an electrical resistor, configured to detect a change in electric potential occurring on the sensor lead and to determine an electrode reference interference signal therefrom. Also described is an interference signal compensation facility; a differential voltage measuring system; and a method for generation an interference-reduced biological measurement signal are described.

An interference signal measuring facility is in a differential voltage measuring system with a signal measuring circuit for measuring bioelectric signals with a number of useful signal paths, each with a sensor electrode. In an embodiment, the interference signal measuring facility has an additional sensor lead for each sensor electrode each of which is electrically connected to a ground connection of a supply lead of a sensor electrode; and a measuring amplifier circuit, for each sensor electrode connected to the additional sensor lead via an electrical resistor, configured to detect a change in electric potential occurring on the sensor lead and to determine an electrode reference interference signal therefrom. Also described is an interference signal compensation facility; a differential voltage measuring system; and a method for generation an interference-reduced biological measurement signal are described.

A finger wearable device for monitoring vital signs at a finger includes a housing, a finger cuff, a plurality of vital sign sensors, and an electrocardiogram (ECG) sensor. The housing includes an interface surface for pressing against the finger. The finger cuff attaches to the housing and has a size and a shape to secure the housing to the finger and force the interface surface against the finger when the finger cuff is worn around the finger. The vital sign sensors are disposed in or on the housing and orientated to measure the vital signs from the finger of a wearer. The ECG sensor is disposed in or on the housing and coupled to first and second electrodes to measure ECG signals. The second electrode is disposed on the interface surface.

A finger wearable device for monitoring vital signs at a finger includes a housing, a finger cuff, a plurality of vital sign sensors, and an electrocardiogram (ECG) sensor. The housing includes an interface surface for pressing against the finger. The finger cuff attaches to the housing and has a size and a shape to secure the housing to the finger and force the interface surface against the finger when the finger cuff is worn around the finger. The vital sign sensors are disposed in or on the housing and orientated to measure the vital signs from the finger of a wearer. The ECG sensor is disposed in or on the housing and coupled to first and second electrodes to measure ECG signals. The second electrode is disposed on the interface surface.

Sensor circuit device for measuring a bio-potential and/or a bio-impedance of a body, including a master circuit, and at least two active bi-electrodes connected to, and remotely powered by, the master circuit via single-wire first connector. The sensor circuit device further includes a single passive current electrode being connected to the master circuit via single-wire second connector. The sensor circuit device cooperates with a biological signal amplifier configured to measure a bio-potential and/or a bio-impedance. Each active bi-electrode is connectable to the biological signal amplifier via the first connector, such that a bio-potential of the body is measurable between the two active bi-electrodes when the active bi-electrodes and the single current electrode are in contact with a surface of the body.