Methods and devices are disclosed for inducing analgesia in a localized region of tissue. Inducing analgesia may be performed by identifying a nerve associated with the localized region, determining a resonant frequency for target neuronal cell membranes of the nerve, and generating a peripheral nerve blockade using the determined resonant frequency. The resonant frequency may be a frequency at which impedance of the nerve approaches a maximum.

Neuromuscular monitoring is described that uses a novel lead assembly and a monitor that can select the appropriate electrodes on the lead assembly and calibrate the stimulation signals applied to the patient through the lead assembly. The monitoring can also set a noise floor value to reduce the likelihood of an erroneous train of four calculations. The present system can automatically sense train of four response of a patient and reduce the likelihood of false train of four indications.

A nerve cuff for establishing a nerve block on a nerve can have a cuff body with a channel for receiving a nerve, a reservoir for holding a drug, and an elongate opening slit extending the length of the cuff body that can be opened to provide access to the channel and can be closed to enclose the cuff body around the nerve. The nerve cuff can also include an electrode for detecting and measuring electrical signals generated by the nerve. A controller can be used to control delivery of the drug based on the electrical signals generated by the nerve.

Systems and methods for stimulating neural tissue are disclosed. An array of optically emissive pixels is configured to deliver light to the neural tissue of a subject. Individual pixels within the array can be addressed to selectively illuminate a portion of the neural tissue when a neurological event occurs. The system can also include an array of microelectrodes in electrical communication with the array of pixels and a power source. A biocompatible substrate can be used to support the microelectrodes pixels, and the power source. A microelectrode circuit and a pixel circuit can also be supported by the biocompatible substrate.

A method of surgically positioning an electrode array at a desired implantation location relative to a nerve. A temporary probe electrode is temporarily positioned adjacent to the nerve and at a location which is caudorostrally separate to the desired implantation location of the electrode array. The implanted position of the probe electrode is temporarily fixed relative to the nerve. During implantation of the electrode array, electrical stimuli are applied from one of the temporarily fixed probe electrode and the electrode array, to evoke compound action potentials on the nerve. Compound action potentials evoked by the stimuli are sensed from at least one electrode of the other of the temporarily fixed probe electrode and the electrode array. From the sensed compound action potentials a position of the electrode array relative to the nerve is determined.

Aspects of this disclosure describe methods and systems for evaluating phrenic nerve integrity of a patient and a ramp-up pulse string for nerve stimulation. Integrity of a nerve may be assessed and therapy may be slowly introduced to the patient. To determine integrity, a nerve is electrically stimulated and a return signal is evaluated. For example, a time lapse and a band width of the return signal may provide information about nerve damage and a location of the nerve damage. In addition to assessing nerve integrity of a patient, a stimulation burst (e.g., an electrical stimulation) may be delivered as a ramped-up pulse string (e.g., a series of pulses with increasing voltages) to achieve smooth breathing. The voltages of a stimulation burst may be increased based on a target tidal volume for the patient. The stimulation burst may be delivered during an inhalation phase of a breath.

Aspects of this disclosure describe methods and systems for evaluating phrenic nerve integrity of a patient and a ramp-up pulse string for nerve stimulation. Integrity of a nerve may be assessed and therapy may be slowly introduced to the patient. To determine integrity, a nerve is electrically stimulated and a return signal is evaluated. For example, a time lapse and a band width of the return signal may provide information about nerve damage and a location of the nerve damage. In addition to assessing nerve integrity of a patient, a stimulation burst (e.g., an electrical stimulation) may be delivered as a ramped-up pulse string (e.g., a series of pulses with increasing voltages) to achieve smooth breathing. The voltages of a stimulation burst may be increased based on a target tidal volume for the patient. The stimulation burst may be delivered during an inhalation phase of a breath.

Aspects of this invention relate to a system and method of neural stimulation for intraoperative nerve monitoring for a living subject. The system includes an optical source configured to generate light; a delivering means coupled to the optical source to deliver the generated light to a target nerve of the living subject for stimulating the target nerve; and a detector coupled to the target nerve to record evoked signals responsive to the stimulation for intraoperatively monitoring of the target nerve.

Aspects of this invention relate to a system and method of neural stimulation for intraoperative nerve monitoring for a living subject. The system includes an optical source configured to generate light; a delivering means coupled to the optical source to deliver the generated light to a target nerve of the living subject for stimulating the target nerve; and a detector coupled to the target nerve to record evoked signals responsive to the stimulation for intraoperatively monitoring of the target nerve.

Disclosed herein is a device, and method for treating heart failure by electrically modulating a splanchnic nerve with an implantable device.