Disclosed herein is a device, and method for treating heart failure by electrically modulating a splanchnic nerve with an implantable device.

The present invention provides devices and methods that can prevent or ameliorate bronchoconstriction by stimulating neural activity, in contrast to those techniques based on denervation, ablation or blocking of neural activity. Methods and devices according to the invention may act responsively or on demand, can preserve neuronal structure and function and will be associated with minimal collateral side-effects. In particular, the invention provides devices and methods in which a signal is delivered to the vagus nerve, for example the cervical vagus nerve or the pulmonary branch of the vagus nerve, in order to stimulate neural activity in the vagal nerve.

The present invention provides devices and methods that can prevent or ameliorate bronchoconstriction by stimulating neural activity, in contrast to those techniques based on denervation, ablation or blocking of neural activity. Methods and devices according to the invention may act responsively or on demand, can preserve neuronal structure and function and will be associated with minimal collateral side-effects. In particular, the invention provides devices and methods in which a signal is delivered to the vagus nerve, for example the cervical vagus nerve or the pulmonary branch of the vagus nerve, in order to stimulate neural activity in the vagal nerve.

The disclosure relates to a tissue culture device and components of a system used to grow, maintain and measure recording from cells. In some embodiments, the tissue culture device is an insert with a surface onto which cells may be plated and grown. Electrodes on or near the surface of the cells can be used to measure electrophysiological data when current is applied to the system.

Methods and apparatus for substantially real-time detection of spike events in neuromuscular data. The method comprises receiving a plurality of neuromuscular signals from a plurality of neuromuscular sensors arranged on one or more wearable devices worn by a user, detecting, based on the plurality of neuromuscular signals or information derived from the plurality of neuromuscular signals, at least one spike event corresponding to firing of an action potential in at least one motor unit, determining, based on the plurality of neuromuscular signals or the information derived from the plurality of neuromuscular signals, a biological source of the detected at least one spike event, and generating at least one output based, at least in part, on the detected at least one spike event and/or the determined biological source of the detected at least one spike event.

An automated EP analysis apparatus for monitoring, detecting and identifying changes (adverse or recovering) to a physiological system generating the analyzed EPs, wherein the apparatus is adapted to characterize and classify EPs and create alerts of changes (adverse or recovering) to the physiological systems generating the EPs if the acquired EP waveforms change significantly in latency, amplitude or morphology.

In some examples, electrical stimulation is delivered to a patient such that selective termination of the stimulation causes a therapeutic effect in the patient after termination of the electrical stimulation to the patient. The electrical stimulation may be insufficient to produce a desired therapeutic effect in the patient during stimulation, but sufficient to induce a post-stimulation desired therapeutic effect following termination of the stimulation. In some examples, the electrical stimulation may be sub-threshold electrical stimulation. In some examples, the desired therapeutic effect may alleviate bladder dysfunction, bowel dysfunction, or other disorders. The stimulation may be selectively terminated in response to one or more therapy trigger events to induce the post-stimulation therapeutic effect.

An intravascular catheter for nerve activity ablation and/or sensing includes one or more needles advanced through supported guide tubes (needle guiding elements) which expand to contact the interior surface of the wall of the renal artery or other vessel of a human body allowing the needles to be advanced though the vessel wall into the extra-luminal tissue including the media, adventitia and periadvential space. The catheter also includes structures which provide radial and lateral support to the guide tubes so that the guide tubes open uniformly and maintain their position against the interior surface of the vessel wall as the sharpened needles are advanced to penetrate into the vessel wall. Electrodes at the distal ends of the guide tubes allow sensing of nerve activity before and after attempted renal denervation. In a combination embodiment ablative energy or fluid is delivered to ablate nerves outside of the media.

Disclosed is a method for execution by an SSEP (Somatosensory Evoked Potentials) system. The method involves acquiring at least one SSEP recording from a subject, and determining if the baseline potential is monitorable based on the at least one SSEP recording. The method also involves acquiring ongoing SSEP recordings from the subject, comparing the ongoing SSEP potentials to the monitorable baseline potential, and upon the ongoing SSEP potentials deviating from the monitorable baseline potential according to a defined criteria, executing an alert. This can allow a medical worker to decide whether to take any corrective action, such as repositioning the subject, with a goal of preventing or mitigating iatrogenic injury to a nervous system of the subject. The SSEP system can be substantially automated, such that there is little reliance on discretion by the medical worker. Also disclosed is a SSEP system configured to implement the method summarised above.

Disclosed is a method for execution by an SSEP (Somatosensory Evoked Potentials) system. The method involves acquiring at least one SSEP recording from a subject, and determining if the baseline potential is monitorable based on the at least one SSEP recording. The method also involves acquiring ongoing SSEP recordings from the subject, comparing the ongoing SSEP potentials to the monitorable baseline potential, and upon the ongoing SSEP potentials deviating from the monitorable baseline potential according to a defined criteria, executing an alert. This can allow a medical worker to decide whether to take any corrective action, such as repositioning the subject, with a goal of preventing or mitigating iatrogenic injury to a nervous system of the subject. The SSEP system can be substantially automated, such that there is little reliance on discretion by the medical worker. Also disclosed is a SSEP system configured to implement the method summarised above.