A neurostimulation system comprises at least one stimulation electrode configured to deliver an electrical stimulus to neural tissue and at least one measurement electrode configured to record a neural recording of a response of the neural tissue to the stimulus. A processor is configured to assess the neural recording to produce a measure of postsynaptic activation.

A neurostimulation system comprises at least one stimulation electrode configured to deliver an electrical stimulus to neural tissue and at least one measurement electrode configured to record a neural recording of a response of the neural tissue to the stimulus. A processor is configured to assess the neural recording to produce a measure of postsynaptic activation.

The disclosure describes devices and methods for providing transdermal electrical stimulation therapy to a subject including positioning a stimulator electrode over a glabrous skin surface overlying a palm of the subject and delivering electrical stimulation via a pulse generator transdermally through the glabrous skin surface and to a target nerve or tissue within the hand to stimulate the target nerve or tissue within the hand so that pain felt by the subject is mitigated. The pulses generated during the electrical stimulation therapy may include pulses of two different magnitudes.

A device for recording evoked neural responses, comprising one or more stimulus electrodes and one or more sense electrodes. The device has a stimulus source for providing a stimulus to be delivered from the stimulus electrodes to a neural pathway in order to give rise to an evoked action potential on the neural pathway. The device has measurement circuitry for recording a neural compound action potential signal sensed at the sense electrodes. Crosstalk cancellation circuitry is configured to produce a stimulus crosstalk cancellation signal, and is configured to inject the stimulus crosstalk cancellation signal into the measurement circuitry. The stimulus crosstalk cancellation signal is configured to cancel a stimulus crosstalk voltage arising upon the one or more sense electrodes as a result of delivery of the stimulus.

A device for recording evoked neural responses, comprising one or more stimulus electrodes and one or more sense electrodes. The device has a stimulus source for providing a stimulus to be delivered from the stimulus electrodes to a neural pathway in order to give rise to an evoked action potential on the neural pathway. The device has measurement circuitry for recording a neural compound action potential signal sensed at the sense electrodes. Crosstalk cancellation circuitry is configured to produce a stimulus crosstalk cancellation signal, and is configured to inject the stimulus crosstalk cancellation signal into the measurement circuitry. The stimulus crosstalk cancellation signal is configured to cancel a stimulus crosstalk voltage arising upon the one or more sense electrodes as a result of delivery of the stimulus.

A system may include neuromodulation electrode contacts, a waveform generator, and a controller. The neuromodulation electrode contacts may be configured and arranged for use in delivering neuromodulation to a target peripheral nerve, where the target peripheral nerve includes a plurality of fibers, and the plurality of neuromodulation electrode contacts is configurable into a plurality of electrode configurations for stimulating different subsets of fibers within the plurality of fibers. The waveform generator may be configured for use to generate neuromodulation energy. The controller may be configured for use for identifying an electrode configuration that, when used to deliver the neuromodulation, stimulates fibers from an inhibitory surround receptive field, identifying a threshold amplitude corresponding to either a perception threshold or an evoked neural threshold for the identified electrode configuration, and delivering sub-perception therapy for the identified electrode configuration using a therapeutic amplitude that is set based on the threshold amplitude.

An automated EP analysis apparatus for monitoring, detecting and identifying changes (adverse or recovering) to a physiological system generating the analyzed EPs, wherein the apparatus is adapted to characterize and classify EPs and create alerts of changes (adverse or recovering) to the physiological systems generating the EPs if the acquired EP waveforms change significantly in latency, amplitude or morphology.

An automated EP analysis apparatus for monitoring, detecting and identifying changes (adverse or recovering) to a physiological system generating the analyzed EPs, wherein the apparatus is adapted to characterize and classify EPs and create alerts of changes (adverse or recovering) to the physiological systems generating the EPs if the acquired EP waveforms change significantly in latency, amplitude or morphology.

The purpose of the present invention is to provide a technique whereby multiple projection targets are efficiently identified from multiple neurons in multiple brain areas with the use of multis-point light stimulation. An acquisition unit 52 acquires spike signals generated from multiple neurons existing in the vicinity of two or more recording sites. A stimulation control unit 51 selects one projection target candidate from two or more candidates in accordance with a definite system on the basis of the spike signals and then determines irradiation timing of light stimulation. Upon the light stimulation, a management unit 53 acquires the spike signals in all of the recording sites within a definite period of time before or after the light stimulation, while dividing the spike signals into anti responses and collision responses. An anti response management unit 81 acquires and manages information relating to the anti responses. A collision response management unit 82 acquires and manages information relating to the collision responses. A priority control section 54 corrects and determines priority depending on the anti response information and the collision response information.

The purpose of the present invention is to provide a technique whereby multiple projection targets are efficiently identified from multiple neurons in multiple brain areas with the use of multis-point light stimulation. An acquisition unit 52 acquires spike signals generated from multiple neurons existing in the vicinity of two or more recording sites. A stimulation control unit 51 selects one projection target candidate from two or more candidates in accordance with a definite system on the basis of the spike signals and then determines irradiation timing of light stimulation. Upon the light stimulation, a management unit 53 acquires the spike signals in all of the recording sites within a definite period of time before or after the light stimulation, while dividing the spike signals into anti responses and collision responses. An anti response management unit 81 acquires and manages information relating to the anti responses. A collision response management unit 82 acquires and manages information relating to the collision responses. A priority control section 54 corrects and determines priority depending on the anti response information and the collision response information.