Methods, systems, and devices are disclosed for evaluating vulnerability, disease progression, and treatments in neuropathologies. In one aspect, a method to provide an assessment related to a neurological or neuropsychiatric disorder includes selecting a profile category indicative of one or more aspects of cognitive or sensory functions associated with a neurological or neuropsychiatric disorder, presenting a sequence of stimuli to a subject, in which the sequence of stimuli is based on the selected profile category, acquiring physiological signals of the subject before, during, and after the presenting of the sequence of stimuli to produce physiological data, and processing the physiological data to generate an information set including one or more quantitative values associated with the selected profile category.

According to various embodiments, systems and methods for determining carbon dioxide detection in arthropods. An embodiment may include determining at least one resonant frequency of an arthropod sensory organ and an absorption spectrum of at least one odorant. A frequency filter may be applied to the absorption spectrum to eliminate frequencies below a given intensity value. Of the frequencies remaining from the absorption spectrum, those frequencies corresponding to relative peaks in absorption intensity may be selected. An olfactory chord including a group of the selected frequencies corresponding to the relative peaks in absorption intensity with at least one specific frequency that matches the at least one resonant frequency of the arthropod sensory organ. Additionally, at least one radiation source may be configured to emit electromagnetic radiation corresponding to the olfactory chord.

A method of screening a pupil of a subject to determine whether the pupil reflex resembles a canonical pupil reflex is disclosed. The method comprises the steps of stimulating the pupil with a stimulus source, such as a pupilometer and determining whether one of various pupillary response conditions is met.

An automated diagnostic system and method for detection of a disease or disorder, comprising: a specialized device; rodents trained to perform a characteristic behavior pattern when exposed to a body fluid-derived test specimen from a subject having the disease or disorder; and a computerized sensing arrangement comprising sensors and a processor utility for receiving said sensed data, processing the sensed data to identify a disease-signifying event and outputting one or more event-related output signals comprising a diagnostic indication.

A method of determining olfactory perception signature of a subject is disclosed. The method comprises: providing the subject with a plurality of physical odorant samples for sniffing; for each sniffed odorant sample, presenting to the subject, by a user interface, a set of odorant descriptors and a respective set of rating controls, and receiving ratings entered by the subject using the rating controls. Each rating is indicative of a descriptiveness of a respective odorant descriptor for the odorant sample, thereby obtaining a set of descriptiveness levels for the odorant sample. The method also comprises calculating, by a computer, relations between pairs of sets of descriptiveness levels corresponding to pairs of odorant samples, to provide a vector of relations, wherein the vector represents the olfactory perception signature of the subject.

Technologies for emotion prediction based on breathing patterns include a wearable device. The wearable device includes a breathing sensor to generate breathing data, one or more processors, and one or more memory devices having stored therein a plurality of instructions that, when executed, cause the wearable device to calibrate a personalized emotion predictive model associated with the user, collect breathing data of the user of the wearable device, analyze the breathing data to determine a breathing pattern, predict, in response to an analysis of the breathing data, the emotional state of the user using the personalized emotion predictive model, and output the emotional state of the user.

Described herein are various apparatus and systems useful in sensory discrimination. Through the use of a multi-well sample plate, the high-throughput analysis apparatus and method allow for rapid sensory discrimination of a large number of samples.

A scent presentation method is provided that includes generating a random number, determining a presentation condition based on the generated random number, and presenting a scent through pulse ejection based on the determined presentation condition.

An olfactory examination apparatus includes: an odor generating unit having an odorant generating mechanism that stores an odorant and generates an odorous gas having a defined concentration or an defined intensity and an odorless gas generating mechanism; a gas supply unit configured to alternately supply an odorous gas or an odorless gas having a defined concentration or a defined intensity of the odor from the odorant generating mechanism and the odorless gas generating mechanism to an examinee through an odor presentation mechanism placed on a nostril portion of the examinee, and a reply unit that allows the examinee to express an answer when smelling the odorant in order to examine an olfactory function.

A system and method for the assessment and therapeutic treatment of neurologic function deficits through the evaluation of voluntary and involuntary neuromuscular activity and voluntary neuromuscular responses made on demand as a response to a cognitive skills test. The system permits the remote assessment and therapy of a patient through prescribed physical and cognitive skills regimens either through the remote direction of a therapist or through an artificial intelligence system that selects and modifies regimens based upon the analysis of historical data and/or real-time data. The combination of physical and cognitive therapy to require physical responses to cognitive queries is believed to improve patient outcomes by slowing, halting, or reversing the progression of certain neurological deficits.