A device and method is provided for stimulation of neurons. The device includes a stimulation unit that can be implanted into a body of a patient and has stimulation elements that apply a stimulation signal to tissue of the patient to stimulate neurons in the brain and/or the spinal cord of the patient. Moreover, a measuring unit receive a measurement signal that reflects a neuronal activity of the stimulated neurons. Further, a control unit generate a modulation signal from the measurement signal, and modulates an amplitude of a pulse train with the modulation signal. Individual pulses of the pulse train include a first and second pulse portions that introduce and remove charge from the tissue. Moreover, the control unit varies a pause between the pulse portions until the synchronization of the stimulated neurons is minimized or falls below a predetermined threshold.

A method for inducing an activity of a user's autonomic nervous system is provided. The method includes steps of: (a) on condition that each of the user's reference heart rate information corresponding to each of active states of the user's autonomic nervous system is obtained, an inducing device, if a specific active state of the autonomic nervous system is selected by the user, acquiring first reference heart rate information of the user corresponding to the specific active state of the autonomic nervous system; and (b) the inducing device supporting a first vibration stimulus with a first period corresponding to the first reference heart rate information to be applied to the user, to thereby allow the user's real-time average cardiac interval to be synchronized with the first vibration stimulus.

A method and device for modulating the autonomic nervous system adjacent a pericardial space to treat cardiac arrhythmia includes a treatment source arranged to supply a treatment medium, a catheter having an end sized for insertion into the pericardial space, a medium delivery assembly having a distal end arranged to be positioned by the catheter into the pericardium, with the distal end of the delivery assembly comprising a delivery tip arranged to extend away from the distal end of the catheter into the pericardial space. A connector operatively couples the delivery tip of the medium delivery assembly to the treatment source, and the delivery tip of the medium delivery assembly including a plurality of delivery points for delivering the treatment medium at a plurality of treatment areas within the pericardial space. The device performs modulation or ablation of the autonomic nervous system at selected treatment areas within the pericardium.

In some embodiments, systems and methods can include a wearable device with an electrically conductive skin interface that excites the underlying nerves from a transcutaneous surface stimulator. The device may be sized for a range of user sizes with stimulation electrodes positioned to target the appropriate nerves, such as the saphenous and/or tibial nerves. The stimulation could include burst stimulation, and involve receiving an input relating to autonomic nervous system activity of the patient, and modifying at least one brain or spinal cord autonomic feedback loop relating to bladder function based on the input to balance parasympathetic and sympathetic nervous system activity of the patient.

In a method and a device for quantification of a respiratory sinus arrhythmia, a heart-rate curve is measured first and then the time elapsed between two heartbeats is determined and quantified by an analysis in the phase domain. A more informative quantification is obtained when suitable coefficients are used or the heart-rate curve is interpolated and/or detrended for the quantification.

A method and an apparatus for analyzing heart rate Variability (HRV), and use thereof are provided. A low-cost, portable and wearable signal acquisition device is utilized to acquire electrocardiography (ECG) signals of epilepsy patients for 24 hours before treatment, and a time domain index, a frequency domain index and a nonlinear index of the ECG during a long term and during a short term are calculated with a programmed HRV analysis method, and the efficacy of vagus nerve stimulation (VNS) treatment for patients with medically intractable epilepsy is accurately and efficiently predicted based on characteristic parameters for characterizing an effect level of the vagus nerve regulating the heart rate, i.e., vagus nerve activity, thereby avoiding unnecessary costs and avoiding the delay of the optimal treatment timing. In addition, the characteristic parameters obtained by the HRV analysis on the ECG may be utilized to clearly select VNS treatment indication patients.

Neurostimulation of a mixed nerve comprising a plurality of nerve fibre types. An implantable electrode array comprising a plurality of electrodes is positioned proximal to the mixed nerve. An electrical stimulus is delivered from at least one nominal stimulus electrode of the implantable electrode array, in accordance with a set of stimulus parameters. A recording of the electrophysiological response evoked by the electrical stimulus is obtained from at least one nominal recording electrode of the implantable electrode array. The recording is analysed by assessing one or more selected characteristics of the recording, and from the observed selected characteristics a level of recruitment of one or more fibre types recruited by the electrical stimulus is identified. The stimulus parameters are refined in a manner to effect selective recruitment of one or more fibre types relative to other fibre types of the mixed nerve.

Systems, methods, and devices for neuromodulation are described herein. For example, a method for modulating inflammatory processes of a subject is described. The method can include stimulating the subject's vagus nerve to activate an efferent pathway, and stimulating the subject's vagus nerve to inhibit neural activity. Pairing activation of the efferent pathway and inhibition of neural activity can enhance an anti-inflammatory response of the subject.

Disclosed is a system for monitoring activities of Autonomic Nervous System (ANS) for preventive medicine comprising: a sensing device configured to sense an involuntary control signal from the ANS of a subject in sleep; and an analyzing device configured to analyze the sensed involuntary control signal received from the sensing device to evaluate a dynamic health condition of the subject, and output the evaluated dynamic health condition.

A method for determining a state of concussion or sub-concussion of an individual by measuring using a monitoring device a plurality of baseline heart rate variability data over a first period of time. The monitoring device transmits said baseline heart rate variability (HRV) data to an application on a smart device. The baseline HRV data is transmitted by said smart device said baseline heart rate variability data to a memory. The monitoring device measures a plurality of contact activity heart rate variability data over a second period of time and transmits the contact activity heart rate variability data to the smart device. The smart device transmits said contact activity heart rate variability data to a memory. A processor analyzes the plurality of baseline heart rate variability data and the plurality of contact activity heart rate variability data in the memory to determine a state of autonomic nervous system dysfunction by comparing the contact activity heart rate variability data with the baseline heart rate variability and communicates said state to said individual via said application on said smart device.