A system and method for assessing a patient includes a portable device for measuring a plurality of autonomic nervous system activities so as to form a baseline profile in a processor connected to the device. The baseline profile corresponds to an initial patient status before an impact event. A biomarker profile is determined by a parasympathetic ANS measurement and parasympathetic and sympathetic ANS measurement based on the baseline profile and a projected patient status for a traumatic brain injury. The device measures the plurality of autonomic nervous system activities after an impact event so as to form a test profile. The test profile is compared to the biomarker profile in a memory of the processor so as to form an injury index. When the injury index is equal or greater than a predetermined level, a traumatic brain injury is detected. An interactive display can indicate the traumatic brain injury.

A method for autonomic nervous system sensitivity-point testing on a skin of a patient is described. The method includes generating an electrotherapy signal that stimulates a vagal response of an autonomic nervous system of the patient when the patient is tested. The method further includes providing an electrically conductive tip that electrically contacts but does not puncture the skin when the patient is tested and coupling the electrotherapy signal to the electrically conductive tip.

Example methods, apparatus, systems and machine readable media are disclosed herein for selecting advertisement or entertainment location based on neuro-response data. An example method includes analyzing first neuro-response data from a first subject exposed to source material. The example method also includes identifying a candidate location in the source material for introduction of an advertisement or entertainment based on the first neuro-response data. In addition, the example method includes analyzing second neuro-response data from at least one of the first subject and a second subject exposed to a combination of the source material and the advertisement or entertainment inserted in the candidate location. The example also includes determining an effectiveness of the advertisement or entertainment based on the second neuro-response data.

There is provided a sound and vibration information collecting mechanism, which collects low-frequency sound and vibration information with a predetermined frequency or lower from a detection target, the mechanism including a resonance layer, which includes a natural oscillator having a natural frequency within a frequency band of the sound and vibration information being a collection target, and generates a resonance carrier by the natural oscillator emphasizing the sound and vibration information; and a sensor, which detects the resonance carrier. The mechanism detects a bioacoustic signal and a biosignal more accurately than conventionally.

A system can include a wearable device that obtains real-time physiological data and activity data from a user and transmits that data to another device. A computing device can receive HRV and activity data and determine whether the user's autonomic nervous system is in a predominantly sympathetic or parasympathetic state. For example, the determination can include comparing an average variance in a portion of the HRV data with a threshold value. In response to determining that the user's autonomic nervous system is in a sympathetic state, the device can perform an action.

A system can include a wearable device that obtains real-time physiological data and activity data from a user and transmits that data to another device. A computing device can receive the data and calculate a first HRV score for the user based on physiological data from first time period and a second HRV score for the user based physiological data from a second time period. The device can present the user with at least one of the first and second HRV scores. In one example, a graphical display is provided on a GUI that includes indicators for each day of the week. In response to a user selecting an indicator for a day of the week, the GUI can display an HRV score for the selected day, among other information.

A basic physical condition of a person is estimated. A biological state estimation device calculates a plurality of indexes indicating variations of states of bioregulation function elements, including an index ascribable to fluctuation highly correlated with a brain function, an autonomic nervous function, bodily and mental fatigue, or sensation, which are obtained from a bioregulation function element judging device, every predetermined judgment times set for the respective bioregulation function elements in advance to find time-series variations of the indexes. A basic physical condition estimating device analyzes the time-series variations in order of priorities. Consequently, it is possible to find a physical condition from fluctuation performance serving as a basis of a regulation system of a person in a basic physical condition estimation time which is set longer than the judgment times of the respective bioregulation function elements.

Methods and related systems for modulating neural activity by repetitively blocking conduction in peripheral neural structures with chemical blocking agents are disclosed. Methods and systems for reversing effects of chemical blocking agents and/or for producing substantially permanent conduction block are also disclosed.

An intravascular catheter for peri-vascular nerve activity sensing or measurement includes multiple needles advanced through supported guide tubes (needle guiding elements) which expand with open ends around a central axis to contact the interior surface of the wall of the renal artery or other vessel of a human body allowing the needles to be advanced though the vessel wall into the perivascular space. The system also may include means to limit and/or adjust the depth of penetration of the needles. The catheter also includes structures which provide radial and lateral support to the guide tubes so that the guide tubes open uniformly and maintain their position against the interior surface of the vessel wall as the sharpened needles are advanced to penetrate into the vessel wall. The addition of an injection lumen at the proximal end of the catheter and openings in the needles adds the functionality of ablative fluid injection into the perivascular space for an integrated nerve sending and ablation capability.

Disclosed is a system for monitoring physiological parameters during a medical interventional procedure involving high intensity/energy radiofrequency electrical currents/voltages applied through a body of a subject, the system including an electrode-based sensor, configured to close an electrical conduction path passing through a body of a subject, and one or more non-electrode-based sensors, a plurality of electrical lines, a monitor, and a filter array including EMI filters mounted at specific locations and characterized by a frequency response curve having a magnitude of an attenuation in a first frequency range (typical of operating frequencies of high intensity/energy radiofrequency medical interventional equipment), which is greater than a magnitude of an attenuation in a second frequency range (typical of the sampling frequencies of the electrode-based sensor and the one or more non-electrode-based sensors), the system being thereby configured for suppressing noise induced by the medical interventional equipment.