Methods of restoring homeostatic capacity of a subject are provided. Aspects of the invention further include compositions, systems and devices for practicing the methods. The methods and compositions described herein find use in a variety of applications. Aspects of certain embodiments of the methods include modulating a subject's autonomic nervous system in a manner sufficient to restore the homeostatic capacity of the subject. Aspects of other embodiments of the invention include administering to the subject an amount of an apoptosis modulator effective to at least partially restore homeostatic function of the neuroendocrine system of the subject.

Systems and methods for determining an abnormal glycemic event using surrogates for glucose are disclosed herein. In an embodiment, a medical system includes a medical device associated with a subject and a processor communicatively coupled to the medical device. The medical device is configured to sense a signal corresponding to a presence of a compound in at least one of: an exhalation breath, interstitial fluid, blood and urine, wherein the compound is a surrogate for glucose. The processor is configured to receive the signal corresponding to the presence of the compound; determine the presence of the compound based on the received signal; and determine the subject is experiencing an abnormal glycemic event in response to the determined presence of the compound.

An intravascular catheter for peri-vascular nerve activity sensing or measurement includes multiple needles advanced through supported guide tubes (needle guiding elements) which expand with open ends around a central axis to contact the interior surface of the wall of the renal artery or other vessel of a human body allowing the needles to be advanced though the vessel wall into the perivascular space. The system also may include means to limit and/or adjust the depth of penetration of the needles. The catheter also includes structures which provide radial and lateral support to the guide tubes so that the guide tubes open uniformly and maintain their position against the interior surface of the vessel wall as the sharpened needles are advanced to penetrate into the vessel wall. The addition of an injection lumen at the proximal end of the catheter and openings in the needles adds the functionality of ablative fluid injection into the perivascular space for an integrated nerve sending and ablation capability.

A monitoring system may include a processor and display system for displaying results from the monitoring. A user may be in a sterile field away from the processor and display system and selected input devices. A controller may be physically connected to the monitoring system from the sterile field to allow the user to control the monitoring system.

A mobile electronic device includes: waveform information acquisition part configured to add a time stamp to a waveform detected from a user and record the waveform with the time stamp as waveform information; condition information acquisition part configured to add a time stamp to information indicating a condition of the user and record the information with the time stamp as condition information; artifact waveform acquisition part configured to acquire, from artifact waveform data in which a condition and the artifact waveform are associated with each other and stored, an artifact waveform that corresponds a condition indicated by the condition information in the same time period as a time period of the waveform information; waveform correction part configured to correct the waveform information using the artifact waveform; and autonomic nerves diagnosis part configured to diagnose autonomic nerves of the user using the waveform information corrected by the waveform correction part.

A wearable device attached to a subject includes an accelerometer that measures acceleration information, and a biological sensor that measures biological signal information of the subject. From the measured acceleration information and biological signal information, first feature data corresponding to a first predetermined period and second feature data corresponding to a second predetermined period are extracted. By machine learning based on the first feature data, a dynamic/static activity identification model, a dynamic-activity identification model, and a static-activity identification model, for the subject, are generated. By combination of results of determination based on each of the identification models, a posture and an activity of the subject are identified, and correspondence information, which associates the identified posture and activity with the biological signal information of the subject, is generated.

An apparatus includes a posture sensing circuit configured to detect a change in posture of a subject; a cardiac signal sensing circuit configured to generate a sensed cardiac signal, wherein the sensed cardiac signal includes heart rate information of the subject; a physiologic sensing circuit configured to generate a sensed physiologic signal, wherein the physiologic signal includes information related to blood pressure of the subject; a storage buffer; and a control circuit operatively coupled to the posture sensing circuit and the storage buffer. The control circuit is configured to initiate storage of the heart rate information and the information related to blood pressure in response to a detected change in posture of the subject.

Provided herein are methods, devices, compositions, and kits for monitoring neuromodulation efficacy based on changes in the level or activity of one or more target biomarkers.

A biological information measuring apparatus according to an embodiment includes a calculating unit and a measuring unit. The calculating unit is configured to calculate information related to a pulse wave of a subject, on the basis of luminance information of a picture signal of the subject. The measuring unit is configured to measure a fluctuation of blood pressure of the subject based on an increase or a decrease in the information related to the pulse wave, in accordance with a site of the subject from which the picture signal was obtained.

A biosignal measuring method and apparatus are provided. The biosignal measuring method includes verifying whether a measured biosignal is in a range, and controlling an operation of the biosignal measuring apparatus when the measured biosignal deviates from the range based on a result of the verifying.