Methods for treating a patient using therapeutic renal neuromodulation and associated devices, systems, and methods are disclosed herein. One aspect of the present technology is directed to biomarker sampling in the context of neuromodulation devices, systems, and methods. Some embodiments, for example, are directed to catheters, catheter systems, and methods for sampling biomarkers that change in response to neuromodulation. A system can include, for example, an elongated shaft and a neuromodulation and sampling assembly having a neuromodulation and a sampling element.

An example computer readable storage medium having stored thereon an information processing program executable by a computer of an information processing device which presents information corresponding to a biological signal acquired from a user, is provided. The information processing program causes the computer to function as biological signal acquiring means, motion/attitude information acquiring means, and presentation means. The biological signal acquiring means acquires the biological signal from the user. The motion/attitude information acquiring means acquires information about a motion or an attitude of the user from detecting means, in association with the biological signal acquired by the biological signal acquiring means. The presentation means performs predetermined presentation based on both the biological signal acquired by the biological signal acquiring means and the information acquired by the motion/attitude information acquiring means.

A system comprises a sensor device and processing circuitry. The sensor device comprises a housing configured to be disposed above shoulders of a patient, a plurality of electrodes on the housing, a motion sensor, and sensing circuitry configured to sense a brain electrical signal and a cardiac electrical signal via the electrodes, and a motion signal via the motion sensor. The processing circuitry is configured to determine values over time of one or more parameters from the brain electrical signal, determine values over time of one or more parameters from the cardiac electrical signal, and generate at least one of a detection, prediction, or a classification a condition of the patient based on the values and the motion signal.

Systems and methods for facilitating patient self-measuring and recording are provided. In some embodiments, an exhalation pressure of a patient may be measured via a pressure transducer during a time period associated with an examination. A graphical component (indicating the exhalation pressure measurement) may be presented on a display such that the graphical component is continuously updated in real-time, as the exhalation pressure is being measured, until at least the end of the time period associated with the examination. Another graphical component (indicating a remaining time of the time period) may be presented on the display such that the other graphical component is continuously updated in real-time, as the exhalation pressure is being measured, until at least the end of the time period associated with the examination. A heart rate of the patient may be measured via electrocardiogram (ECG) electrodes during the time period associated with the examination.

A system to identify and predict atrial fibrillation includes a memory configured to store one or more electrograms and one or more nerve recordings of a patient. The system also includes a processor operatively coupled to the memory and configured to identify one or more atrial fibrillation characteristics based on the one or more electrograms and the one or more nerve recordings, where the one or more atrial fibrillation characteristics include oxidative stress and fibrosis. The processor is also configured to identify a progression state of the atrial fibrillation based on the one or more atrial fibrillation characteristics.

Diagnostic methods for assessing the parasympathetic and sympathetic nervous systems separately and simultaneously are disclosed. These methods involve collecting pulse and respiratory data during a series of repeated, escalating challenges, and plotting the data on a time series utilizing signal processing. From this data, parasympathetic excess (PE), sympathetic excess (SE), and alpha-sympathetic withdrawal (SW) can be determined, and several conditions diagnosed and treated based on the observation of PE, SE, and/or SW during various stages of the challenges.

A driver abnormality determination apparatus includes circuitry configured to detect a driver state of a driver of a vehicle, detect a driving operation of the driver, detect an exertion level of an involuntary function of the driver based on the driver state, detect an exertion level of a driving function of the driver based on the driving operation; and determine driver abnormality based on the execution level of the involuntary function and the execution level of the driving function. On condition that a function level of one of the execution level of the involuntary function and the execution level of the driving function is equal to or lower than a specified determination criterion, the circuitry is configured to relax a determination criterion for the other function level.

Provided herein are methods, devices and compositions for assessing neuromodulation efficacy based on changes in the level of one or more biomarkers in plasma or urine collected from a human subject following a renal neuromodulation procedure.

Disclosed are devices, systems and methods for neural signal detection of immune responses. In some aspects, a system includes a processing unit: a receiving unit configured to receive at least one sensor signal from a wearable sensor, where the wearable sensor is configured to detect at least one neural signal of a patient; and a tangible non-transitory computer readable medium having instructions configured to cause the processing unit to automatically receive a data signal from the receiving unit, automatically detect an immune response based at least in part on the data signal, automatically create a notification based at least in part on the immune response, and automatically present the notification to a user of the system.

In some examples, nerves surrounding arteries or leading to organs are targeted with energy sources to correct or modulate physiologic processes. In some examples, different types of energy sources are utilized singly or combined with one another. In some examples, bioactive agents or devices activated by the energy sources are delivered to the region of interest and the energy is enhanced by such agents or the agents are enhanced by the energy sources.