An intraluminal microneurography probe has a probe body configured to be introduced into an artery near an organ of a body without preventing the flow of blood through the artery. An expandable sense electrode and an expandable stimulation electrode are fixed to the probe body at one end of each electrode such that movement of the other end toward the fixed end causes the sense electrode to expand from the probe body toward a wall of the artery. A ground electrode is configured to couple to the body, and a plurality of electrical connections are operable to electrically couple the electrodes to electrical circuitry. The sense electrode is operable to measure sympathetic nerve activity in response to excitation of the stimulation electrode. A radio frequency ablation element is located between the expandable sense electrode and expandable stimulation electrode, and is operable to ablate nerves proximate to the artery.

A computer-implemented system for training a subject to improve psychophysiological function for performance of stress-inducing activity includes a sensor interface device and a non-transitory, tangible computer readable storage medium storing computer program code. The sensor interface provides measurement of a physiological parameter of the subject, indicating stress in the subject. The computer readable storage medium stores computer code that provides a set of training segments presenting the subject with one or more visual, audible, or tactile prompts wherein at least one of the training segments simultaneously presents the subject with a stress-inducing prompt while inducing the subject to perform a relaxation-inducing protocol.

A neurostimulation system comprises at least one stimulation electrode configured to deliver an electrical stimulus to neural tissue and at least one measurement electrode configured to record a neural recording of a response of the neural tissue to the stimulus. A processor is configured to assess the neural recording to produce a measure of postsynaptic activation.

A signal processing system includes an expiratory information acquisition unit and a nerve recognition uni. The expiratory information acquisition unit acquires expiratory information as a piece of biometric information about a person's expiratory volume. The nerve recognition unit recognizes, based on a dispersion in the expiratory information, a condition of the person's autonomic nervous system.

A measurement apparatus includes a first biometric sensor configured to measure, as a biological signal, at least one of a brain wave signal and a pulse wave signal of a living body, a second biometric sensor configured to measure a respiratory rate of the living body per unit time, a differential operation unit configured to calculate a differential value of a periodic feature of the biological signal, an activity level analysis unit configured to analyze an activity level of an autonomic nerve of the living body based on the differential value, and an activity level correction unit configured to correct the activity level of the autonomic nerve by eliminating a component caused by respiration of the living body and included in the activity level of the autonomic nerve based on the respiratory rate of the living body per unit time.

The invention relates to a method for determining the physical and/or psychological state of a subject. The heart rate variability (HRV) of the subject is analyzed in the time domain, wherein at least one frequency distribution of interbeat intervals (IBI) which are detected in at least one examination time period (1) is examined in the analysis. In order to obtain particularly significant and quickly interpretable information for this purpose, the frequency distribution is examined for a multimodal distribution.

A system for electro-therapeutically treating a patient includes a stimulatory device electromagnetically coupled with the nervous system of a patient, an electrical power supply, and a control mechanism structured to energize the stimulatory device by way of the electrical power supply at a stimulation frequency. The control mechanism is further structured to control the energizing so as to produce a treatment signal encoded in the energizing and having a treatment signal frequency equal to or less than the stimulation frequency.

Systems and methods for monitoring patient vasoactivity are discussed. An exemplary patient monitor system includes a sensor circuit configured to generate a heart sound (HS) metric using a HS signal sensed from a patient, and a vasoactivity monitor configured to monitor vasoactivity, such as degree of vasoconstriction or vasodilation, using the HS metric. The system can provide the monitored vasoactivity to a user to alert patient hemodynamic responses to vasoactive drugs, or initiate or adjust a vasoactive therapy according to the vasoactivity. The system may use the monitored vasoactivity to detect a medical condition such as worsening heart failure, pulmonary edema, or syncope.

A biological information measurement apparatus including: a light emitting unit that irradiates a living body with light; and a light receiving unit that receives light scattered at a plurality of measurement sites in the living body, in which the biological information measurement apparatus includes a mechanism in which the light scattered at the plurality of measurement sites is individually detected by a plurality of the light receiving units or the same light receiving unit. Also provided is a biological information measurement system including: a light emitting device that irradiates a living body with light; and a light receiving device that receives light scattered at a plurality of measurement sites in the living body, in which the biological information measurement system includes a mechanism in which the light scattered at the plurality of measurement sites is individually detected by a plurality of light receiving units or the same light receiving unit.

A system and method for collection and interpretation of data for determining impairment by intoxicant(s) in a subject at the point of collection utilizes of multiple sensors which may comprise both a live-cell assay in a disposable cartridge for determining the presence of intoxicant(s) and an eye scanner for determining vital signs and neurological state of the subject. The cartridge may be equipped to intake a sample, process it, and/or interact it with one or more eukaryotic cell-based biosensors. A cartridge may function as an optical interface to relay signals from the biosensors to a detector. The eye scanner may be equipped with optical sensors for the detecting both vital signs and neurological state. Each optical sensor may be spectrally filtered to identify a biomarker or set of biomarkers. Another method utilizes the eye scanner to train a model to identify additional biomarkers within the live-cell assay on a cartridge to increase the specificity for impairment by the primary analyte. One such example of this approach is to identify combinations of cannabinoids, both endogenous and plant-derived, which when found together with D.sup.9-tetrahydrocannabinol (THC), confer a higher probability that THC is actively impairing the test subject.