A telestroke eye examination accessory device, a system incorporating the same, and methods of using the same, are described. The telestroke eye examination accessory device includes eyewear having a first eye well and a second eye well, a first camera positioned within the first eye well, a second camera positioned within the second eye well, a first light array having lights in each of four different quadrants in the first eye well, and a second light array having lights in each of four different quadrants in the second eye well. The system further includes a graphical user interface useful for a practitioner using the telestroke eye examination accessory device to assess the field of vision of a patient wearing the eyewear.

A flexible printed circuit board (FPCA) of a brain computer interface (BCI) module is configured to interconnect a plurality of emitter assemblies and a plurality of detector assemblies of the BCI module. The FPCA comprises a connector portion for connecting the FPCA to a controller of the BCI module, a plurality of rigid sections, a plurality of flexible sections. A first subset of rigid sections is configured to mount the plurality of emitter assemblies. A second subset of rigid sections is configured to mount the plurality of detector assemblies. Each flexible section is configured to attach the two or more rigid sections of the plurality of rigid sections to each other. The plurality of flexible sections allows the plurality of emitter assemblies and the plurality of detector assemblies to stretch to conform to a head of a user.

In some examples, a processor of a system evaluates a therapy program based on a score determined based on a volume of tissue expected to be activated (“VTA”) by therapy delivery according to the therapy program. The score may be determined using an efficacy map comprising a plurality of voxels that are each assigned a value. In some examples, the efficacy map is selected from a plurality of stored efficacy maps based on a patient condition, one or more patient symptoms, or both the patient condition and one or more patient symptoms. In addition, in some examples, voxels of the efficacy map are assigned respective values that are associated with a clinical rating scale.

A system and method for detecting brain concussion includes detecting and measuring of acceleration at one or more points on a subject's head. Sensors, which can be accelerometers placed against the head, detect and measure natural motions of the patient's head due to blood flow in the brain and resultant movement of tissue in the brain. The acceleration data are then analyzed, including as to frequency of motions of the skull at the subject location in a frequency range of about 1 to 20 Hz. An observation is then made, as compared with data corresponding to non-concussion, of a change in frequency response pattern exhibited when accelerations are plotted as a function of time or frequency, to identify probable concussion if the frequency response pattern indicates concussion. Preferably the observation and comparison are made by a computer using an algorithm.

A test apparatus or system for testing impact induced brain trauma a method of making and a method using the same are provided. The system includes a head model, which includes a skull component, a brain component, and a fluid component. The skull component has a wall defining an interior chamber. The brain component includes a gel material and is disposed within the interior chamber. The fluid component is disposed inside the interior chamber. The system may also include a fluid tank fluidly coupled with the skull component and configured to provide the fluid component into the interior chamber. The head model may further include a layer of porous media disposed between the brain component and the interior wall surface of the skull component. The system may include at least one impact element for providing an impact on the head model. The impact is translational or rotational or both.

A neurostimulation system comprises at least one stimulation electrode configured to deliver an electrical stimulus to neural tissue and at least one measurement electrode configured to record a neural recording of a response of the neural tissue to the stimulus. A processor is configured to assess the neural recording to produce a measure of postsynaptic activation.

The physical and physiological events at one end of an Abreu Brain Thermal Tunnel (ABTT) are reproduced at the opposite end. Thus, the ABTT enables the direct transfer of outputs from a brain core to an ABTT terminus without significant barriers. Accordingly, apparatuses, systems, devices, mechanisms, and methods use the ABTT terminus and the ABTT to measure the temperature of the brain core.

A device and system for non-invasively measuring wavelength-dependent changes in optical absorption of brain tissue damaged by CTE, TBI, concussion, repetitive trauma, and/or Lou Gehrig’s disease in comparison to signals from healthy normal tissue for a subject in vivo. The brain, tissues, and fluids superficial to the brain are trans-cranially illuminated by light source(s) in low-absorption spectral windows for tissue in the visible and/or near-infrared parts of the spectrum. Optode(s) are disposed at predetermined radial distance(s) from a light output to collect the scattered and/or deflected signal from the surface of the head. The predetermined radial distance from the light output to the optode is correlated with the depth of tissue penetration for the light collected by the optode. A spectrometer and computer analyze the collected light for characteristic optical signatures of the brain tissue damage utilizing the absorbance and/or reflectance and/or transmission spectra generated as a result.

A device is provided for stimulating neurons that includes a non-invasive stimulation unit that generates stimuli in multiple stimulation channels. The stimulation unit generates the stimuli to stimulate a neuron population in the brain and/or spinal cord of a patient using the stimulation channels in different locations. Moreover, the device includes a control unit that controls the stimulation unit to repeatedly generates sequences of the stimuli with the order of the stimulation channels in which stimuli are generated within a sequence being constant for 20 or more successively generated sequences before it is varied.

A method and apparatus for stimulating neural activity in the brain of a user of an apparatus with a display screen by causing at least one portion of the display screen to flicker in a controlled manner and utilizing the apparatus to measure an effect on a user exposed to the flicker for a time.