Systems and methods for treating cancerous tumors (including glioblastoma multiforme (GBM)) with electrotherapy, such as deep brain stimulation (DBS) technology, as disclosed herein. One or more configurations can be generated based on a patients tumor characteristics. The selected configurations can be electrode configurations or settings for an electrical source coupled to the electrodes. The one or more configurations can be targeted for inhibiting cell growth process, such as to inhibit mitosis, immune suppression, or to inhibit DNA replication. Inhibition of cell growth processes can initiate death of the cancerous cells.

Systems, methods, and devices for automatic generation of a stimulation therapy that mimics electrographic activity in the brain at natural seizure termination define a stimulation therapy to be generated by an implanted component of a medical device system and delivered to a subject through identifying data characterizing a patient's seizures, especially at termination. A machine learning model identifies the seizures or seizure types from which to establish a canonical seizure or seizure type, and an algorithm translates the canonical seizure or seizure type into data that can be used to characterize a stimulation therapy. The systems, methods, and devices, include those configured to deliver the stimulation therapy that emulates the canonical seizure or seizure type when the seizure is detected, with the aim of terminating the seizure sooner than it would terminate without intervention.

A system for computer-aided triage includes a router, a remote computing system, and a client application. A method for computer-aided triage includes receiving a data packet associated with a patient and taken at a point of care; checking for a suspected condition associated with the data packet; in an event that the suspected condition is detected, determining a recipient based on the suspected condition; and transmitting information to a device associated with the recipient.

Described herein are methods and systems for analyzing a sample by applying time resolved laser induced fluorescence spectroscopy to the sample to measure lifetime time decay profile data relating to the sample, and applying multivariate analysis to process the data so as to classify a sample as, for example, normal or abnormal. The sample may be cells, fluid or tissue from any organ. The sample may be in vitro or in vivo. The data may be obtained in situ or in vitro.

An active skull replacement system including an implant having an area A, an upper surface, and a bottom surface, adapted to be implanted at least in part into a skull of a subject so to substitute a portion of the skull, the bottom surface arranged to face at least in part a cranial cavity, and having a first wireless bidirectional data communication device, a device operably connected to the bottom surface of the implant, the device adapted to at least one of stimulate a physiological response and record a physiological parameter of the subject, and an external reader adapted to be placed on the scalp of the subject and including a second wireless bidirectional data communication device configured to communicate with the first wireless bidirectional data communication device of the implant to operate the device, wherein the external reader and the implant are fixed and aligned among each other through a magnetic device.

The subject matter disclosed herein relates to a method for determining dopamine function in a subject, the method comprising acquiring one or more neuromelanin-Magnetic Resonance Imaging (NM-MRI) scans of the subject's dopamine-associated brain region of interest.

A processing subsystem generates perceived images from information bearing nerve impulses that are transmitted from a subject's eye(s) to a visual processing region of the subject's brain along one or more nerves in response to the subject viewing a real-world scene. The processing subsystem generates display images based on the perceived images, and controls a display device to display the display images to the subject. In certain embodiments, the processing subsystem generates the display images by manipulating or modifying the perceived images to include virtual images, and provides a type of virtual pointing on the display images that is used to invoke one or more actions.

Support structures for positioning sensors on a physiologic tunnel for measuring physical, chemical and biological parameters of the body and to produce an action according to the measured value of the parameters. The support structure includes a sensor fitted on the support structures using a special geometry for acquiring continuous and undisturbed data on the physiology of the body. Signals are transmitted to a remote station by wireless transmission such as by electromagnetic waves, radio waves, infrared, sound and the like or by being reported locally by audio or visual transmission. The physical and chemical parameters include brain function, metabolic function, hydrodynamic function, hydration status, levels of chemical compounds in the blood, and the like. The support structure includes patches, clips, eyeglasses, head mounted gear and the like, containing passive or active sensors positioned at the end of the tunnel with sensing systems positioned on and accessing a physiologic tunnel.

An intracortical-detection device including: at least one electrode that contacts a group of neurons; a first body, forming a surface that contacts a portion of a cerebral region; a first motor that moves the electrode with respect to the first body; a second motor; and a second body, operatively connected to the second motor, the first and second bodies being able to slide with respect to one another in a first direction, under the action of the second motor. The detection device moreover includes a sensor generating an electrical signal indicating a pressure exerted by the portion of cerebral region on the surface.

A movement monitor sensor includes a body, a conduction area, at least one depth electrode set and a flat electrode set. The body has an axis and two axial ends. The conduction area at one axial end connects a conductive wire. The depth electrode set includes four separate depth electrodes disposed on the body by surrounding the axis and connected individually with first wires. The flat electrode set includes a substrate disposed at another axial end and four separate flat electrodes disposed at the substrate by surrounding the axis and connected individually with second wires. The conductive wire, the first and second wires are individually connected with the conduction area, the depth electrodes and the flat electrodes. When a human movement changes, a processor evaluates impedance variations generated by the depth electrode set, the flat electrode set and/or the conduction area to determine electrical stimulation control upon human brain.