Methods and apparatus for predicting performance of an individual on a task, the method comprises receiving brain imaging data for the individual, wherein the brain imaging data comprises structural brain data, determining values for at least one characteristic of the structural brain data within regions of interest defined for a population of individuals having different performance levels, and predicting based on the determined values, a performance potential of the individual.

A system for testing and/or training the vision of a user is disclosed herein. The system includes a motion sensing device, a visual display device having an output screen, and a data processing device operatively coupled to the motion sensing device and the visual display device. In one embodiment, the data processing device is programmed to generate and display a configuration of a visual object on the visual display device during the same cycle of rotational head displacement when the actual head velocity or speed for the user reaches or exceeds a prescribed threshold percentage of the target velocity or speed. In another embodiment, the data processing device is programmed to increase a value of a prescribed amplitude or period for the head rotational displacement of the user for a successive trial of a test or training routine when a peak head velocity or speed is determined to have increased.

Neural activity in the brain arising from a stimulus is monitored. A stimulus is applied to a target structure of the brain and a neural measurement is obtained from at least one electrode implanted in contact with the target structure. The neural measurement is configured to capture a measure of any late response arising in the target structure, typically being a neural response arising after conclusion of an ECAP, such as in the period 1.5-10 ms after stimulus onset. The late response(s) can be a useful biomarker such as of therapeutic ranges of deep brain stimulation, disease progression, medication efficacy, and intra-operative changes.

Systems and methods are disclosed related to using acoustic waves to detect neural activity in a brain and/or localize the neural activity in the brain. Sensors positioned outside of a skull encasing the brain can detect acoustic waves associated with the neural activity in the brain. From output signals of the sensors, a particular type of neural activity (e.g., a seizure) can be detected. A location of the neural activity can be determined based on outputs of the sensors. In some embodiments, the ultrasound energy can be applied to the location of the neural activity in response to detecting the neural activity.

The invention relates to a multi-step method with a number of processes and sub-processes that interact to allow for the selection, design and/or manufacture of a protective sports helmet for a specific player, or a recreational sports helmet for a specific person wearing the helmet. Once the desired protective sports helmet or recreational sports helmet is selected, information is collected from the individual player or wearer regarding the shape of his/her head and information about the impacts he/she has received while participating in the sport or activity. The collected information is processed to develop a bespoke energy attenuation assembly for use in the protective helmet. The energy attenuation assembly includes at least one energy attenuation member with a unique structural makeup and/or chemical composition. The energy attenuation assembly is purposely engineered to improve comfort and fit, as well as how the helmet responds when an impact or series of impacts are received by the helmet.

A method for detection or monitoring status of silent brain ischemia (SBI) and cerebrovascular health. The assay reagents and methods described herein provide a specific indicator of cerebral microvascular disease, enabling clinicians to identify patients at risk for the development of SBI. A method of treating a subject having silent brain ischemia and/or metabolic syndrome comprises administering to the subject aspirin therapy, blood pressure therapy, body weight management, and/or a program of diet and exercise when levels of two or more SBI markers are elevated. Described herein are molecules that are produced by cerebral endothelial cells exposed to chronic vascular risk factors including obesity, hyperlipidemia, hypertension, and glucose intolerance. These stress molecules produced by cerebral endothelial cells are detectable in the serum and serve as diagnostic indicators of brain-specific endothelial cell damage and correlate with MRI indicators of silent stroke and impaired cognitive function.

Methods, systems, and apparatus, including computer programs encoded on computer storage media, for generating a mental health prediction for a patient using a centrality ranking of the brain of the patient. One of the methods includes obtaining brain data of a patient, wherein the brain data comprises, for each of a plurality of pairs of parcellations formed from a set of parcellations where each pair comprises a first parcellation and a second parcellation, data characterizing a number of tracts connecting the first parcellation and the second parcellation; determining a network graph from the brain data; generating, for each of a plurality of nodes in the network graph, a measure of centrality of the node; determining a centrality ranking of the plurality of nodes of the network graph according to the respective measures of centrality; generating a mental health prediction for the patient using the determined centrality ranking.

Provided here are non-invasive methods for evaluating functional connectivity patterns in localized brain regions of a patient involving application of a MS-specific functional meta-analytic connectivity model in resting-state functional magnetic resonance imaging (rsfMRI) data to provide patients with appropriate medical care in response to output from the model.

Compositions and methods are provided for the detection and/or diagnosis of traumatic brain injury.

An endomicroscopic device, which, in microsurgical operations, enables the deep surgical sites that cannot be seen from a certain angle to become visible. The endomicroscopic device includes a light source to illuminate the surgical site, a microscope lens for taking and magnifying an image of a tissue at the surgical site, a pair of binocular eyepieces for projecting the image to eyes of the surgeon, an endoscopic probe for displaying blind areas outside of a field of view of the at least one microscope lens from different angles in a periscopic manner, an endoscopic probe outlet, and a distal portion located at an end of the endoscopic probe. The distal portion is flexible and can be angled to be directed to different areas, and provides a second periscopic image.