Embodiments regard nutrition assessment using a handheld device. An embodiment of an apparatus includes a handle with a controller within the handle, an attachment arm extending from the handle, and a user-assistive device coupled with an end of the attachment arm, wherein the apparatus is to determine a mass held by the user-assistive device, the determination being made during a task by a user of the handheld tool including manipulation of the handheld tool.

The present invention relates to a method of preventing or reducing one or more adverse post-anaesthetic effects in a patient, comprising treating the patient with low level laser therapy (LLLT) prior to anaesthesia and/or during anaesthesia and/or following anaesthesia, and to a method for assessing whether a patient is at risk of suffering from adverse post-anaesthetic effects, comprising determining whether the patient contains a polymorphism in a gene encoding one of the following proteins: (a) protein associated with assembly and disassembly of microtubules; (b)ion channel protein; (c) membrane stability protein; (d) Melanocortin systems proteins; (e) proteins associated with Alzheimer's and/or Parkinson's vulnerability; or (f) proteins associated with migraine.

The invention relates to in vitro method for quantitating the antibodies specific for High mobility group box I (HMGB1) contained in a sample, in particular a serum sample or a cerebrospinal fluid sample obtained from a patient, and the use of this method in the prognostic and/or diagnosis of neurological disorders. These methods are in particular applicable to the monitoring of the human immunodeficiency virus (HIV) infection of a subject who is known to be infected with HIV and in the prognostic and/or diagnostic of the state of progression of Acquired immune deficiency syndrome (AIDS) or the state of progression toward AIDS, in particular the state of progression or the state of progression toward neurological disorders associated with AIDS. Finally, the invention is also about method to determine the immune deficiency or level of immune activation of a patient, in particular a HIV-infected patient.

In some examples, a system may include a plurality of electrodes, electrical stimulation circuitry, and a controller. The controller may be configured to select one or more parameters of therapy to be delivered to a brain of a patient and to control the electrical stimulation circuitry to deliver the therapy to the brain of the patient based on the selected parameters and via a first one or more electrodes of the plurality of electrodes. The parameters may be defined based on a first plurality of electrical signals sensed at a plurality of different positions within the brain of the patient when electrical stimulation is not delivered at each of the positions and a second plurality of electrical signals sensed at each of the plurality of different positions within the brain of the patient in response to electrical stimulation delivered at each of the positions at a plurality of different intensities.

Embodiments of the present systems and methods may provide a non-invasive system to measure and integrate behavioral and cognitive features enabling early detection and progression tracking of degenerative disease. For example, a method of detecting neurodegenerative disease may comprise measuring functioning of at least one of the motor system, cognitive function, and brain activity of a subject during everyday life and analyzing the gathered at least one motor system data, cognitive function data, and brain activity data of the subject.

Embodiments may provide multimodal diagnostic systems and methods for detecting neurological disorders, such as Alzheimer's disease (AD), Parkinson's disease (PD), depression, PTSD, schizophrenia, dementia and many others. For example, a system for monitoring brain activity may comprise a plurality of sensors, each adapted to monitor a physical or physiological parameter and output a signal representing the monitored physical or physiological parameter, wherein the plurality of sensors includes at least one sensor configured to monitor a brain activity parameter, a data collection device adapted to receive the plurality of signals from the plurality of sensors and to process the signals to form digital data representing the monitored physical or physiological parameters, and a data processing device adapted to process digital data representing the monitored physical or physiological parameters to determine presence of a neurological disorder or condition.

The present invention relates to a neural implant comprising a biomaterial having an outer surface with a stochastic nanoroughness (Rq), and the application of said stochastic nanoroughness in the diagnosis and/or treatment of a neurological disorder, such as, for example, Parkinson's disease, Alzheimer's disease, glioblastoma and/or for disrupting and/or preventing glial scars in the context of mammalian mechanosensing ion channels selected from the family of PIEZO-1 and PIEZO-2 ion channels.

Methods and system for assessment of a state of the central nervous system (CNS) of a subject and/or differentiation between states of the CNS at a specific time point based on electrophysiological recordings of signals from at least two anatomical structures, wherein the signals are recorded from recording sites located in the anatomical structures, wherein the electrophysiological recordings comprise spatiotemporal fluctuations in the recorded extracellular potential, wherein the electrophysiological recordings are action potentials and/or local field potentials (LFPs) in the anatomical structures and represent the state of the CNS, a s well as the use of the method for assessment of a state of the CNS and/or differentiation of at least two states of the CNS, as well as to the use of the method for evaluating the effect of a treatment of a condition or disease, wherein the condition or disease is neurological and/or psychiatric.

The present invention addresses the problem of limiting power consumption and radio wave interference when assessing the movements of multiple sites of a living body. The present invention is a movement function assessment system provided with: a movement function measurement apparatus for calculating movement data on the basis of the relative distances of pairs of transmission coils and reception coils attached to movable portions of a living body; and an assessment apparatus for assessing the movement function of the living body on the basis of the movement data received from the movement function measurement apparatus. A control unit of the movement function measurement apparatus performs the switching of the multiple transmission coils by a switching unit (1) and the switching of the multiple reception coils by a switching unit (2) so that the paired transmission coils and reception coils are operated sequentially.

One or more EMG sensors are configured to sense surface-EMG data indicative of muscle movement of the patient; and transmit surface-EMG data. A controller can identify at least one parameter of the surface-EMG data; compare the parameter to a corresponding dystonia-threshold-value; responsive to a determination that the parameter is greater than the corresponding dystonia-threshold-value: issue a visual-engagement command to a visual unit; and issue a tactile-engagement command to a tactile unit.