The present invention discloses indicator fluids, reference indicator fluid, and usage thereof, and systems and methods for assessing movement of molecular substances within, to or from a cerebrospinal fluid, brain or spinal cord compartment of a human cranio-spinal cavity. Indicator fluid moving from the cerebrospinal fluid compartment enables measurements of levels of indicator fluid in blood or urine and assessment of the cranio-spinal cavity's ability to remove molecular substances. The indicator fluids may be contrast agents used for imaging, such as by computed tomography imaging, and magnetic resonance imaging, or imaging utilizing radioactive substances by positron emission tomography, single-photon emission computed tomography or scintigraphy. Using these imaging modalities, the invention describes indicator fluids, systems and methods enabling assessment of movement of substances within, to or from a cerebrospinal fluid, brain or spinal cord compartment of a cranio-spinal cavity, and from the human cranio-spinal cavity to lymphatic pathways or kidneys.

Embodiments of the present systems and methods may relate to a non-invasive system with diagnostic and treatment capacities that use a unified code that is intrinsic to physiological brain function. For example, in an embodiment, a computer-implemented method for affecting living neural tissue may comprise receiving at least one signal from at least one read modality, the signal representing release of photons from mitochondria of the living neural tissue, computing at least one signal to effect alterations to the living neural tissue based on the received input signal, the computed signal adapted to cause transmission of photons to the living neural tissue, and delivering the photons to the living neural tissue to effect alterations to the living tissue.

The invention provides a headgear apparatus for performing vestibular assessment of a user. The headgear apparatus includes a processor, a memory and a display device for displaying a plurality of visual stimuli and a hardware means to provide a plurality of non-visual stimuli to the user. A plurality of infrared cameras and an inertial measurement device are employed for measuring eye movement and head movement in response to visual stimuli/non-visual stimuli provided to the user and generating one or more graph based patterns. Headgear apparatus further includes a laser source for providing a laser beam to be projected on a surface during presentation of non-visual stimuli. Accordingly, a machine learning model is employed for interpreting the one or more graph based patterns to detect the presence of an abnormality.

Systems and methods for wireless deep brain stimulation using ultrasonic waves. Implantable device(s) for intracranial use within a subject may comprise at least one stimulation means, one or more circuits for collecting system data, a receiver, and a transmitter for communications using ultrasonic waves. A wearable controller external to the subject, the wearable controller configured to: communicate with the implantable device(s) using the ultrasonic waves and obtain the system data, analyze the system data to determine whether the subject is experiencing or is expected to experience an adverse medical condition, and communicate with the implantable device(s) using the ultrasonic waves to apply a stimulation to treat the adverse medical condition. The system may be used to treat Parkinson's Disease, for example.

In some embodiments, the systems and methods of the disclosure can efficiently and accurately classify neurodegenerative disorder(s) and/or movement disorder(s) of a subject (e.g., a patient) using at least quantitative features associated with one or more regions of interest determined from one or more sets of image data of the subject's brain. The method may include processing one or more sets of MRI image data of the subject's brain to extract one or more quantitative features for one or more regions. The one or more quantitative features may include a first quantitative and a second quantitative feature. The method may further include classifying at least the one or more quantitative features into one or more classes associated with neurodegenerative dementia disorder, neurodegenerative movement disorder, non-neurodegenerative movement disorder and/or heathy control. The method may include generating a report including a classification of at least the one or more quantitative features.

Methods for diagnosing if a patient is suffering from a stroke include: positioning a headset around the patient's head to receive vibrations generated by a cerebral vasculature of the patient's brain, the headset including at least one microphone or accelerometer; processing the received vibrations to obtain a signal; analyzing the signal to identify a pattern indicative of a stroke; and determining that the patient is suffering from a stroke based upon the result of a CT scan of the patient's brain and neck and the identified pattern indicative of a stroke.

Systems and methods for physical therapy and training delivery are presented herein. These technologies may comprise notifying a patient of a scheduled prescribed activity via an on-location at least one client device or console; identifying the patient with one or more sensors connected to or part of the at least one client device or console; confirming, via the at least one client device or console, the patient's acknowledgment of the notification; demonstrating, via a graphical interactive avatar displayed on the at least one client device or console, the prescribed activity to be carried out by the patient; confirming, via the at least one client device or console, that the patient is undertaking or will be undertaking the prescribed activity; capturing, via the one or more sensors, frames of the patient undertaking the prescribed activity; and processing frames of the patient undertaking the prescribed activity.

The invention provides a method of treating, preventing or ameliorating Parkinson's disease with Prasinezumab; wherein providing the patient with a mobile device programmed to receive and transmit data acquired to measure passive and/or active movement of the patient (b) collecting data transmitted from the mobile device; and (c) comparing the data acquired from the patient with control data to assess presence or extent of movement deficits in the subject and/or monitoring the data acquired from the patient for a period of time sufficient to identify changes in the patient's active or passive motor function.

Disclosed is a system and method for tracking progression of Parkinson's Disease using a plurality of wearables worn by a patient. The real time data from the plurality of wearables is used to calculate a progression index for Parkinson's Disease based on Slowness/Stiffness, Tremor profiling, Gait changes and speech distortions. The progression index determines the stage of Parkinson's Disease based on intensity of symptoms mentioned above. The results are shared with a medical professional for evaluating current treatment strategies.

An apparatus and method for assessing vascular compliance in subjects with multiple sclerosis using sequential gas delivery is provided. The apparatus includes a gas delivery device and a processor. The processor controls the gas delivery device to deliver a first and second gas during a single inspiration. The first gas contains a mixture of oxygen and carbon dioxide necessary to target an end-tidal concentration of the two gases. The second gas includes a concentration of carbon dioxide equal to the target end-tidal concentration of carbon dioxide.