A brain disease diagnosis assistance system acquires a plurality of learning data items, each including brain wave feature data including feature amounts of brain waves extracted from the brain waves and disease information attached to the brain wave feature data, the disease information indicating a state of a brain disease corresponding to the brain wave feature data and classifies the plurality of acquired learning data into a plurality of clusters. A classifier for classifying learning data into portions corresponding respectively to types of disease information is generated based on disease information attached to learning data in each classified cluster. Then, brain wave feature data of a subject is acquired and a cluster to which the brain wave feature data is classified is specified and one of a plurality of brain diseases, which corresponds to the brain wave feature data of the subject, is determined through the generated classifier.

Methods and systems for diagnosing a condition of a central nervous system are provided. A method includes providing a DBSI-MRI data set obtained from the central nervous system of the subject, and transforming the DBSI-MRI data set to obtain at least one DBSI biomarker value. The method further includes comparing each DBSI biomarker value to at least one corresponding threshold value from a diagnostic database to obtain a relation between each DBSI biomarker value and the at least one corresponding threshold value, and diagnosing the condition according to at least one diagnostic rule, wherein each diagnostic rule defines a candidate condition in terms of the relations between the at least one DBSI biomarker value and the at least one corresponding threshold value.

A method, device and non-transitory digital storage medium for estimating non-aqueous tissue volume of at least a portion of a subject. The method includes, in a processing unit, obtaining quantitative magnetic resonance properties of the portion of the subject, providing the quantitative magnetic resonance properties as input to a tissue model, and determining the non-aqueous tissue volume of the portion based on the tissue model and the quantitative magnetic resonance properties.

Assistance may be provided to a first user of a first device by monitoring sensors of the first device and providing assistance via a character presented by the device. Sensor data, such as audio, video, or biometric data, may be transmitted to a server, and a server may process the sensor data to determine a state of the first user. The server may determine to request assistance based on the state of the first user. The server may then send a request to a second device of a second user to guide the character presented by the first device. The second user may then provide assistance to the first user by guiding the character presented by the first device.

A system and/or method for determining human health uses a head-worn apparatus that comprises a head orientation sensor, an eye imaging device, and an electronic circuit. The head orientation sensor is configured for generating an electrical head orientation signal in response to head pitch or head yaw. The eye imaging device is configured for observing an eye feature from the sclera, cornea, iris, or pupil, and generates an eye electrical signal in response to eye position, horizontal eye movement, vertical eye movement, pupil size or eyeblinks at a plurality of times. The electronic circuit is configured for generating an ocular parameter measurement such as saccades, vestibulo-ocular reflex, vestibulo-ocular reflex cancellation, vergence, smooth pursuit, nystagmus, dynamic visual acuity, pupil size, and/or eyeblinks from the head and eye electrical signals. The ocular parameter measurement can be used to determine normal human health, a neurologic disorder, a biochemical health impairment, or a physiologic health impairment.

There are provided a system, an apparatus, a program, and a method for enabling objective evaluation of a three-dimensional cognitive ability through quantification. A three-dimensional cognitive ability of a measurement target person is evaluated by acquiring a position of a moving object, the position enabling identification of a distance between the moving object and the measurement target person, by receiving input of an active response of the measurement target person taken in response to a three-dimensional position of the object recognized by the measurement target person, and by determining whether the position of the object that is acquired and the response that is input correctly match. The moving object may be provided in virtual reality by a virtual reality headset, and the three-dimensional cognitive ability may also be evaluated by displaying a moving image of when the object seen from a predetermined point of view is moved in virtual reality from a movement start position to a movement end position, in a direction of approaching the predetermined point of view along a predetermined movement route, and based on a response corresponding to a position of the object.

A device that suppresses a pathological synchronous and oscillatory neuron activity, and includes a non-invasive stimulation for stimulation, using stimuli, of neurons in the patient's brain and/or spinal cord, where those neurons are showing pathologically synchronous and oscillatory neuron activity, and the stimuli are designed to suppress are this activity when administered to the patient. Moreover, a measuring unit records measurement signals reflecting the neuron activity of the stimulated neurons and a control and analysis unit controls the stimulation unit to administer stimuli, check the success of stimulation based on the measurement, and, if the stimulation success is not sufficient, insert one or more stimulation breaks in the application of the stimuli or extend one or more stimulation breaks, where no stimuli that could suppress the pathological synchronous and oscillatory neuron activity are applied during the stimulation breaks.

An embodiment of the invention provides a method to control a mechanical system based on the cognitive state of a user, where a first action is performed at an input device that is associated with the user. The cognitive state of the user is detected at the input device; and, a change to the first action is determined based on the cognitive state of the user. A controlled action is performed based on the recommended change. A system can include an input device associated with user, where a first action is performed at the input device. A processor connected to the input device detects the cognitive state of the user at the input device and determines a change to the first action based on the cognitive state of the user. A controller connected to the processor performs a controlled action based on the recommended change.

The methods, apparatuses, computer-readable media, and systems described enable regions of electromagnetic spectra that may distinguish different biological specimens to be determined. Regions of electromagnetic spectra that distinguish known biological specimens then become candidates for methods to classify unknown specimens and/or make a medical diagnosis. A fraction-product, determined from two arrays associated with two groups, may be used to determine optimal discriminants for the two groups given numerical measurements of particular properties of the members of both groups.

An apparatus and method for aiding in the detection of dementia, concussion, other neurologic conditions, retinal, and optic nerve conditions. The apparatus enables the diffusion coefficient of the tissue to be ascertained and studied by directing the light from a laser or other coherent light source at the patient's retina, optic nerve or choroid and measuring the fluctuations in the intensity of the back-scattered light caused by the movement of light scatterers in the tissue. By comparing the measurements to a normal database, or to the subject's previous measurement, in combination with an eye examination and OCT image/measurement the changes caused by the disease and the effectiveness of therapy can be ascertained. The disclosed apparatus allows the incident and detection optics to be attached to ophthalmic devices typically used in ophthalmologic care. Also, where both the incident laser fiber optic and the detection fiber optic are directly connected to goggles, one or more or all of the above-described mirrors may not be necessary, as both fiber optics are preferably directly directed into the eye.