The present disclosure relates to a method and a system for quantifying a biomarker of a biological tissue. Two spectral sub-intervals are determined from a plurality of images of the tissue acquired at discrete wavelengths within a main wavelength interval using an imaging sensor in a manner such that the combination of the image data in the at least two spectral sub-intervals are correlated with a clinical variable of interest. The tissue is illuminated using one or more light sources with wavelengths within the at least two spectral sub-intervals. A measurement is of the light reflected by the tissue is acquired using an imaging sensor; and a measure of the biomarker of the tissue is calculated using the acquired measurement. The main wavelength interval is broader than each of the at least two spectral sub-intervals and at least one spectral confounder causing a spectral variability of the acquired image is present in the tissue.

The present relates to a computer-implemented method for detecting and predicting cognitive pathologies of the brain based on a Hold and Release process. The invention also concerns a device related to the claims method.

A brain-function image data augmentation method includes: a step of providing a target database including a plurality of image-data information; a step of, based on a plurality of image-data expected information in an expectation-value database, calculating a ratio of the plurality of image-data expected information with respect to different ages; a step of, based on the plurality of image-data information and the ratio, obtaining image-data ratio information with respect to an estimated age; a step of establishing a relationship for each pair of the image-data information and the image-data expected information; a step of, based on the relationship, the ratio and the image-data information, calculating an estimated image-data information with respect to the estimated age; and, a step of combining linearly the estimated image-data information and the image-data ratio information so as to generate an augmented image-data information with respect to the estimated age.

In some aspects, a sensor includes an optical transmitter that transmits to a brain of a person infrared radiation, and an acoustic receiver that detects an ultrasound signal generated in the brain in response to the infrared radiation. A processor determines oxygen saturation of the brain based on the detected ultrasound signal. The sensor may be included in a cap worn by the person, implanted under the skin of the person, or inserted through the nasal canal of the person.

In some aspects, a closed-loop system for monitoring and/or treating brain function of a person includes a CMUT device that transmits ultrasound radiation to the brain of the person and receives and detects an ultrasound signal generated in the brain, and a processor that assesses the received ultrasound signal to determine brain function and controls further transmission of ultrasound radiation from the CMUT device based on the determined brain function.

Provided is a technique for supporting a diagnosis in determining disease by using various types of measured values acquired by a medical image acquisition apparatus. An image diagnosis support device includes a measured-value receiving unit configured to receive various types of measured values at a plurality of positions within a living body, a group generator configured to generate groups of the measured values depending on the position or the type of the measured value, an intermediate index calculator configured to calculate an intermediate index from the measured values included in the group on a per-group basis, and a comprehensive index calculator configured to calculate a comprehensive index from values of the intermediate index calculated on a per-group basis. The intermediate index and the comprehensive index are displayed on a display unit in a display mode such as numerical values and in the form of an image.

Discussed herein is a parametric model for DTI MD histogram fitting, named the Generalized Voss-Dyke function, which is highly successful in segregating NPH cases from potential confounders without reliance on operator dependent region-of-interest analyses or inter-subject registration. The Generalized Voss-Dyke function is useful for managing the imaging of any tissue interfaces.

A throat microphone system and method are disclosed. Certain people may have difficulty vocalizing, such as those suffering from neurodegenerative diseases. The throat microphone system includes a microphone unit that wirelessly communicates with an external device, such as a receiver unit in combination with a smartphone or a smartphone. The microphone unit includes a microphone and a wireless transceiver to wirelessly transmit sound data generated by the microphone. The smartphone processes the sound data in order to increase the intelligibility and/or the volume. Further, the microphone unit may attach to the neck of the wearer and may encircle the neck less than the entire perimeter of the neck. In this way, the microphone unit may be easily removed in the event the wearer is in distress. Moreover, the throat microphone system may include a non-audio sensor, such as a vibration sensor or an electromyograph sensor, in order to determine whether the wearer is voicing speech.

A system for preventing wandering of an individual includes: a wearable alert device worn by the individual and including a controller, an antenna in communication with the controller, an alert component in communication with the controller for providing an alert to the wearer of the alert device, and a power supply in communication with the controller; and at least one base unit including a controller, the at least one base unit in communication with the alert device. When the alert device is determined to be in an area of caution in relation to the at least one bas unit, an alert is generated on the alert device that is perceptible to the wearer of the bracelet, the alert including one or more of arrhythmic vibrations and audible sounds.

Systems and methods of the present disclosure are directed to systems and methods for treating cognitive dysfunction in a subject in need thereof. The system can include a neural stimulation system that receives an indication of an ambient audio signal detected by a microphone. The system selects, from a profile, an audio signal including a fixed parameter and a variable parameter. The system sets the variable parameter to a first value. The system generates an output signal based on the fixed parameter and the first value, and provides the output signal to the speaker. The system measures a physiological condition of the subject, adjusts the variable parameter to a second value, generates a second output signal based on the fixed parameter and the second value of the variable parameter, and provides the output signal to the speaker to cause the speaker to provide modified sound to the subject.