Disclosed herein are novel devices comprising small, ultra-low power microelectronic components. In some instances, the microelectronic components is combined with a biosensor component that enables in situ detection of biomolecules. Also disclosed herein are methods of detecting signal analytes and methods of monitoring the health of a patient using these novel devices.

An apparatus for determining a position of an object inside a body includes a first detector configured to receive a signal from the object inside the body. The apparatus also includes a camera configured to capture an image or video of outside of a portion of the body. The object is positioned inside the portion of the body. A connoting system is configured to receive the signal from the first detector and the image or video from the camera and to determine the position of the object inside the body. A screen is configured to display die position of the object inside the body.

A system for diagnosing an esophageal disease includes at least one processor and at least one memory storing instructions. The instructions, when executed by the at least one processor, cause the system to: access, during a procedure involving an in-vivo device located within a person, data measured by the in-vivo device relating to an esophageal disease; evaluate, during the procedure while the in-vivo device is located within the person, a diagnosis for the esophageal disease for the person by applying a trained machine learning model to the data measured by the in-vivo device; and communicate, during the procedure while the in-vivo device is located within the person, the diagnosis for the esophageal disease.

An anatomical manometry catheter system, comprising a plurality of balloons on the distal end and being configured to be inflatable and/or deflatable. The system includes a connector assembly coaxially aligned with the catheter assembly, the connector assembly being connectable to the proximal end of the catheter. The connector assembly may have a connector interface connected to the proximal end of the catheter. The connector assembly may include a manifold comprising a plurality of channels configured to deliver the pressure transmission medium therethrough toward a respective catheter lumen for inflating one or more balloons. The connector assembly may include a charging mechanism fluidly coupled to the catheter that facilitates inflating each balloon of the plurality of balloons by a common actuating mechanism so as to simultaneously charge each balloon of the plurality of balloons.

An example assembly for use with a vacuum system and an esophageal positioning device esophageal positioning device includes an introducer, in which the esophageal positioning device includes a handle, a first segment, a second segment and an articulation driving mechanism. The first segment being coupled to the handle. The second segment being pivotally connected to the first segment. The articulation driving mechanism being configured to pivot the second segment about the first segment upon articulation.

The present invention provides an improved breath analyzer and breath test method to determine the presence of a gastrointestinal disorder in a subject's digestive tract.

A gastrointestinal stimulation apparatus and methods with an electronic controller and a flexible and stretchable electrode array with a central branch and orthogonal bilateral branches that wrap around a section of the gastrointestinal tract and can accommodate repetitive contraction and relaxation movements of the tract. Array branches have a flexible spring structure, stimulation electrodes, recording electrodes, sensors controlled by a controller and adhesion nodes that fix the branches to the tissue. The electrode array can sense the normal peristalsis from upstream tissue and produce a stimulus signal to stimulate the incapable intestine section to generate stimulation-induced contractions. Electrodes on the incapable intestine section can be used for stimulation or recording, the recorded signal from the incapable intestine section can be sent back to the electronics to form a closed loop control system. An impedance measurement using current stimulation can be used to capture low frequency contraction signals.

A mucosal impedance measuring apparatus detects and measures a condition of mucosa. The mucosal impedance measuring apparatus includes a catheter comprising a tube, impedance sensing electrodes on an exterior surface of the catheter, a balloon mounted on the tube in which the balloon is capable of inflation and deflation, and an impedance measuring system. The impedance measuring system is adapted to measure a pressure-regulated impedance measurement of the mucosa that is indicative of the condition of the mucosa when the balloon is inflated and the impedance sensing electrodes direct an electric current through mucosa while the balloon is pressed against the mucosa.

An in vivo temperature control system includes a catheter insertable into a biological lumen; two or more temperature sensors placed such that they can measure a temperature distribution in a longitudinal direction of the biological lumen; a liquid storage section that stores a liquid; and a control section that estimates a spatial change in the biological lumen based on a temperature change before and after the liquid in the liquid storage section is released outwardly through the catheter, wherein the temperature change is measured by each of two or more temperature sensors.

An enteral feeding system including: an enteral feeding tube, a pump configured to draw a liquid from a reservoir to the enteral feeding tube; a switching mechanism associated with at least four vacuum lumens provided with the enteral feeding tube; and a controller configured to automatically control the pump and the switching mechanism wherein controlling the pump and the switching mechanism includes coordinating the operation of the switch with the operation of the pump.