The present disclosure relates generally to the field of pregnancy devices. More specifically, the present disclosure relates to a wearable apparatus that alerts an expecting mother of unsafe lying or sleeping positions. An exemplary wearable apparatus consistent with the present disclosure comprises an adjustable belt member having an elongated axis of sufficient length to cover the girth of an expecting mother during the entire term of her pregnancy. Further, an attachment coupled to the wearable apparatus is present to secure the alarm belt to the expecting mother. In addition, sensors coupled to the wearable apparatus detect when the expecting mother is lying or sleeping in a supine position in which the sensors send signals to an external alarm. Furthermore, a power source may be coupled to the sensors to provide power thereto.

This invention relates to an ingestible drug delivery device configured for wireless communication with other ingestible drug delivery devices.

A method of managing pain using neurophysiological data acquired from the brain of a subject is disclosed. The method comprises: identifying activity-related features in the data; parceling the data according to the activity-related features to define a plurality of capsules, each representing a spatiotemporal activity region in the brain; comparing at least some of the defined capsules to at least one reference capsule; and assessing the likelihood that the subject is experiencing pain responsively to the comparison.

A system comprising an implantable medical device and processing circuitry. The implantable medical device comprises one or more sensors configured to continuously sense one or more physiological characteristics of a body of a maternal patient, and sensing circuitry operably connected to the one or more sensors and configured to issue one or more output signals indicative of the one or more physiological characteristics. The processing circuitry is configured to define one or more patient attributes using the one or more output signals; and generate an output based on the one or more patient attributes, the output configured to cause a computing device to provide an indication of preeclampsia of the maternal patient to a user.

Methods and a system are provided for assessing postpartum hemorrhage risk and postpartum hemorrhage stages in a clinical setting. Generally, a clinician may indicate that the mass of several bloody items, indicated in type and quantity, is to be measured using a scale. The mass of bloody items is compared to the known unused dry mass of such items in order to accurately determine the quantitative blood loss (QBL) of a patient at the bedside. The cumulative QBL can be updated by weighing additional items. Based on the cumulative QBL, the patient's vital signs, and other factors, a corresponding hemorrhage stage is identified and communicated to the clinician. Recommendations specific to the hemorrhage stage are provided to a clinician. Some recommendations are selectable actions that trigger automatic placement of medical orders and notifications to relevant medical services, such as a blood bank or anesthesia.

The present invention provides a method for measuring the body fat percent and fat accretion during pregnancy, which preferably utilizes a Fourier transform near infrared spectroscopy (FT-NIR) fat determination method. The FT-NIR results can be used to measure and monitor body fat percent, and used to measure the mother's fat accretion rate. A method to monitor weight gain in a pregnant subject is provided wherein the body fat percentage of the subject is maintained at a constant level during gestation, and the subject's fat accretion rate is monitored so as to follow the fat accretion rate provided by using pre-defined fat accretion determination formulae. By measurement of the body fat percent and fat accretion rates, the weight gain of a subject can be monitored and/or controlled during pregnancy.

Particular aspects of the invention are methods for assaying metabolite levels in samples from a patient during pregnancy using nuclear magnetic resonance and direct flow injection mass spectrometry. In various methods, the assayed metabolites may be acylcarnitine or one or more of C3-OH (hydroxypropionylcarnitine), C5-OH (C3DC), C10, C5:1-DC (glutaconylcarnitine), C14:1-OH (hydroxytetradecenoylcarnitine) and C14:2-OH. One or more methods also may include measuring nuchal translucency of the fetus. Other methods relate to predicting fetal congenital heart defects in a fetus.

This invention relates to an ingestible drug delivery device configured for wireless communication with other ingestible drug delivery devices.

Embodiments disclosed herein are directed to devices, systems, and methods for monitoring pregnancy of a female pregnant subject. For example, a pregnancy monitoring system can detect movement or motion of a pregnant subject and/or of the fetus in the pregnant subject. Additionally or alternatively, the pregnancy monitoring system can detect internal and/or external source loads applied to the pregnant subject. In an embodiment, the pregnancy monitoring system can compare and/or correlate two or more loads, one to another (e.g., to produce an output that is at least partially based on such comparison and that is related to the wellbeing of the pregnant subject and/or of the fetus). For example, the pregnancy monitoring system can include a controller that is configured to determine and compare two or more loads based on signals received from one or more sensors that can be positioned on the pregnant subject.

Embodiments disclosed herein are directed to devices, systems, and methods for monitoring pregnancy of a female pregnant subject. For example, a pregnancy monitoring system can detect movement or motion of a pregnant subject and/or of the fetus in the pregnant subject. Additionally or alternatively, the pregnancy monitoring system can detect internal and/or external source loads applied to the pregnant subject. In an embodiment, the pregnancy monitoring system can compare and/or correlate two or more loads, one to another (e.g., to produce an output that is in part based on such comparison and that is related to the wellbeing of the pregnant subject and/or of the fetus). For example, the pregnancy monitoring system can include a controller that is configured to determine and compare two or more loads based on signals received from one or more sensors that can be positioned on the pregnant subject.