A method and system for registering a pre-operative 3D medical image volume of a target organ to intra-operative ultrasound images is disclosed. An intra-operative 3D B-mode ultrasound volume and an intra-operative 3D ultrasound elastography volume are acquired. Patient-specific boundary conditions for a biomechanical tissue model of a target organ are determined using the intra-operative 3D B-mode volume. Patient-specific material properties for the biomechanical tissue model of the target organ are determined using the 3D ultrasound elastography volume. The target organ in the pre-operative 3D medical image volume is deformed using the biomechanical tissue model with the patient-specific material properties with the deformation of the target organ in the pre-operative 3D medical image volume constrained by the patient-specific boundary conditions.

It consists of a system for palpation of the rectal face of the prostate that transforms the information collected into objective, reproducible and useful information. The system makes it possible to identify areas of high rigidity reaching the entire peripheral area, transforming a diagnostic maneuver for prostate cancer into an objective one, which until now has been subjective and unreliable. All this in a short space of time, carried out in a less aggressive and more objective way than rectal examination. The device consists of a manual electronic instrument with a handle (1) and a scanning rod (3), which includes at least two concentric force/pressure sensors of different heights, as well as an ultrasonic imaging system which, through means of connection to external devices for analysis/control, allows the data obtained to be analyzed and the anatomy of the prostate being analyzed to be visualized in real time.

The present invention provides a graph-based prostate diagnosis network (GPD-Net) and a method for using the same to predict a prostate health status of a patient from a 3D magnetic resonance imaging (MRI) scan containing a plurality of 2D MRI slices. The GPD-Net only demands patient-level annotations of MRI scan for training by formulating the diagnosis task of 3D prostate MRI scan in a multi-instance learning (MIL) strategy, and regarding each 2D MRI slice in the 3D prostate MRI scan as an instance. The GPD-Net includes a plurality of importance-guided graph convolutional layers to explore the diagnostic information with the importance-based topology. The present invention provides accurate prediction of prostate diseases and achieve more reliable diagnosis from MRI scans, therefore can effectively alleviate the workload of clinician in viewing the slices of MRI scan.

Methods and apparatus for computer-aided prostate condition diagnosis are disclosed. An example computer-aided prostate condition diagnosis apparatus includes memory to store instructions and a processor. The example processor can detect a lesion from an image of a prostate gland and generate a mapping of the lesion from the image to a sector map, the generating the mapping of the lesion comprising identifying a depth region of the lesion, wherein the depth region indicates a location of the lesion along a depth axis. The processor can also provide the sector map comprising a representation of the lesion within the prostate gland mapped from the image to the sector map.

A urine collector includes a receptacle formed of a water soluble material, which may be a bioplastic, and has a receiving volume for collecting urine therein defined by its shape. The urine collector is configured to float in water in a toilet for use by a user to collect urine therein. A threshold volume indicator configured to correspond to a predetermined threshold volume may be included. A patch may be included in the interior surface to detect the presence and/or levels of various components in the urine. The urine collector may be stackable. The water soluble material may be layered on a substrate, which may be a thin sheet of paper, and may further be a non-stick paper product, such as parchment paper.

A device for capturing and concentrating volatile organic compounds (VOCs) in a sample of breath air. The device includes an intake for accepting an air sample; a disposable mouth piece; a sensor array for measuring physical parameters of the air sample; an exhaled air sampler for capturing a pre-determined volume of air; a concentrator for concentrating VOCs in the air sample; and an ionic liquid collector, the latter of which may be removed from the device. The ionic liquid collector, which may have one compartment or multiple compartments, includes at least one ionic liquid. Analysis of VOCs in the ionic liquid or liquids may identify biomarkers that can provide a medical diagnosis for a human patient based on a sample of breath air.

A system for providing integrated guidance for positioning a biopsy device and estimating tumor size in a body has two levels of guidance: a coarse guidance and a fine guidance. The system includes a non-invasive imaging system for obtaining an image of the biopsy device in the body, for providing the coarse guidance. Furthermore, the system includes an optical element mounted on the needle for obtaining optical information discriminating tissue in the body, for providing the fine guidance.

Systems and methods are disclosed that facilitate obtaining two dimensional (2D) ultrasound images, using two or more ultrasound imaging modes or modalities, to generate 2D multi-parametric ultrasound (mpUS) images and/or to generate a three-dimensional (3D) mpUS image. The different ultrasound imaging modes acquire images in a common frame of reference during a single procedure to facilitate their registration. The mpUS images (i.e., 2D or 3D) may be used for enhanced detection of suspicious regions.

An orifice probe, particularly for detecting if a patient has or has a risk of having cauda equina syndrome and a method for using same, the probe having a body for insertion into the anus of a patient, a sensing device for measuring at least one of the rectal tone and perianal or rectal sensation, and an output device for yielding at least one of the measurement of the rectal tone of the patient and whether the patient has perianal or rectal sensation.

Systems and methods for mapping a cavernous nerve near an organ. The system includes: one or more processors; and a memory that is communicatively coupled to the one or more processors and stores one or more sequences of instructions, which when executed by one or more processors causes steps to be performed comprising: applying an excitation signal to an electrode at a tip of an laparoscope, the tip being configured to contact a point on a tissue near an organ; responsive to the excitation signal, measuring a change in a signal from a pair of electrodes configured to be installed on the penis, the change in the signal being associated with an erectile function of the penis; and based on the change in the signal from the pair of electrodes, determining a distance between the point on the tissue and a cavernous nerve near the organ.