A magnetic resonance imaging device for prostate examinations with a patient in said device comprises a coil for generating a strong homogeneous magnetic field in the direction of the longitudinal axis of the patient, at least one transmission coil for generating an electromagnetic alternating field, three gradient coils and suitable reception coils, of which individual coils are arranged below the patient in the lower back region and/or at the rear part and at least one of said coils is arranged above the patient, and also comprises data processing for obtaining images from the signals of the transmission and reception coils, wherein a closed reception coil is provided which sits closely against the patient and surrounds the scrotum and the penis.

Methods and apparatus associated with producing a quantification of differences associated with biochemical recurrence (BcR) in a region of tissue demonstrating prostate cancer (PCa) are described. One example apparatus includes a set of logics, and a data store that stores a set of magnetic resonance (MR) images acquired from a population of subjects. The set of logics includes an image acquisition logic that acquires a diagnostic image of a region of tissue in a patient demonstrating PCa, a morphology logic that extracts a shape feature, a volume feature, or an intensity feature from the diagnostic image or from a member of the set of MR images, a differential atlas construction logic that constructs a statistical shape differential atlas from the set of MR images, and a quantification logic that produces a quantification of differences based on the shape feature, the volume feature, or the intensity feature, and the differential atlas.

A system and method for testing tissue in a patient. An optical probe illuminating the tissue generates reflected light corresponding to the illuminated tissue. A spectrometer and a tissue classification system provide a diagnostic classification. A treatment device delivers treatment to the tissue while the probe is in position to sense the reflected light.

D-Histo, a non-invasive diagnostic method, renovated from diffusion basis spectrum imaging (DBSI) is provided for quantitatively detecting and distinguishing inflammation from solid tumors, heart and nerve injury. For example, the D-Histo methods disclosed herein provide an accurate diagnosis of prostate cancer, distinguishing it from prostatitis and BPH that missed by currently available methods of diagnosing prostate cancer (multiparameter MRI, needle biopsy). The disclosed D-Histo method also provides metrics to reflect reversible vs. irreversible damages in heart and central/peripheral nerves. For central and peripheral nerves, D-Histo also provides metrics to assess nerve functionality. The at least one D-Histo biomarker obtained using diffusion weighted MRI has excellent test-retest stability, high sensitivity to disease progression and close correlation with currently available techniques.

An MRI safe robot for guiding transrectal prostate biopsy comprises a support arm, a robot body operatively connected to the support arm and a transrectal biopsy device operatively connected to the robot body. The transrectal biopsy device includes an endorectal extension and a biopsy needle device, the endorectal extension including an MRI coil for MRI imaging of the prostate. The robot body includes a first driver module for generating rotational motion of the endorectal extension and a second driver module for angulating the biopsy needle device toward a target area of the prostate for biopsy. The biopsy needle device is rotatable relative to the endorectal extension about a fixed axis and translatable through the endorectal extension. Each of the first and second driver modules include at least one pneumatic motor, wherein the MRI images are used by a physician to determine the target area for biopsy.

A time reversal optical tomography (TROT) method for near-infrared (NM) diffuse optical imaging of targets embedded in a highly scattering turbid medium is presented. TROT combines the basic symmetry of time reversal invariance and subspace-based signal processing for retrieval of target location. The efficacy of TROT is tested using simulated data and data obtained from NIR imaging experiments on absorptive, scattering and fluorescent targets embedded in Intralipid-20% suspension in water, as turbid medium, as well as, a realistic cancerous model breast assembled using ex vivo human breast tissues with two embedded tumors. The results demonstrate the potential of TROT for detecting and locating small targets in a turbid medium, such as, breast tumors in early stages of growth.

In some examples, a medical system includes a medical device. The medical device may include a housing configured to be implanted in a target site of a patient, a light emitter configured to emit a signal configured to cause a fluorescent marker to emit a fluoresced signal into the target site, and a light detector that may be configured to detect the fluoresced signal. The medical system may include processing circuitry configured to determine a characteristic of the fluorescent marker based on the emitted signal and the fluoresced signal. The characteristic of the fluorescent marker may be indicative of a presence of a compound in the patient, and the processing circuitry may be configured to track the presence of the compound of the patient based on the characteristic of the fluorescent marker.

A method for performing magnetic resonance imaging is provided. The method includes providing a magnetic resonance imaging system comprising: a radio frequency receive system comprising a radio frequency receive coil, and a housing, wherein the housing comprises a permanent magnet for providing an inhomogeneous permanent gradient field, a radio frequency transmit system, and a single-sided gradient coil set. The method also includes placing the receive coil proximate a target subject; applying a sequence of chirped pulses via the transmit system; applying a multi-slice excitation along the inhomogeneous permanent gradient field; applying a plurality of gradient pulses via the gradient coil set orthogonal to the inhomogeneous permanent gradient field; acquiring a signal of the target subject via the receive system, wherein the signal comprises at least two chirped pulses; and forming a magnetic resonance image of the target subject.

An ultrasound imaging system include a console with transmit circuitry configured to generate an excitation electrical pulse that excites transducer elements of a probe to produce an ultrasound pressure field and configured to receive an echo signal generated in response to the ultrasound pressure field interacting with tissue. The console further includes receive circuitry configured to convert the echo signal into an electrical signal, and an echo processor configured to generate a live ultrasound image based on the electrical signal into. The console further includes a tracking processor configured to extract, in real-time, a feature common to both the live ultrasound image and previously generated volumetric image data from at least the live ultrasound image, and register, in real-time, the live ultrasound image with previously generated volumetric image data based on the common feature extracted in real-time to create the fused image. A display displays the fused image.

A system for disease diagnosis includes a patch neural network for generating a patch-level diagnostic result of whether or not a disease is present in each of predetermined patches formed by dividing a slide into a predetermined size; a heat map generation module for generating a patch-level heat map image corresponding to the biometric image obtained from the slide on the basis of the patch diagnostic results of the respective multiple patches included in the slide; a tissue mask generation module for generating a tissue mask image corresponding to the biometric image obtained from the slide on the basis of a hue-saturation-value (HSV) model corresponding to the slide; and a visualization module for generating a disease diagnostic visualization image corresponding to the biometric image obtained from the slide on the basis of the patch-level heat map image and the tissue mask image.