Systems and methods for analyzing pathologies utilizing quantitative imaging are presented herein. Advantageously, the systems and methods of the present disclosure utilize a hierarchical analytics framework that identifies and quantify biological properties/analytes from imaging data and then identifies and characterizes one or more pathologies based on the quantified biological properties/analytes. This hierarchical approach of using imaging to examine underlying biology as an intermediary to assessing pathology provides many analytic and processing advantages over systems and methods that are configured to directly determine and characterize pathology from underlying imaging data.

Systems and methods relate to multi-modal imaging of tissue combined with highly focused radiation interventions. The system is a portable multimodal imaging unit that integrates imaging and image analysis. The system can be retrofitted to use with any commercial radiation therapy machine. In one aspect, a system integrates various imaging modalities into a single, coordinated structure. The system integrates X-ray and cone beam computed tomography (CBCT), optical imaging (such as bioluminescent imaging (BLI), fluorescence tomography (FT)), and positron emission tomography (PET) imaging in a single, self-contained structure.

The invention relates to a computer-implemented method (10) for determining the blood volume flow (I.sub.BI) through a portion (90.sub.i, i=1, 2, 3, . . . ) of a blood vessel (88) in an operating region (36) using a fluorophore. A plurality of images (80.sub.1, 80.sub.2, 80.sub.3, 80.sub.4, . . . ) are provided, which are based on fluorescent light in the form of light having wavelengths lying within a fluorescence spectrum of the fluorophore, and which show the portion (90.sub.i) of the blood vessel (88) at different recording times (t.sub.1, t.sub.2, t.sub.3, t.sub.4, . . . ). By processing at least one of the provided images (80.sub.1, 80.sub.2, 80.sub.3, 80.sub.4, . . . ), a diameter (D) and a length (L) of the portion (90.sub.i) of the blood vessel (88) and also a time interval for a propagation of the fluorophore through the portion (90.sub.i) of the blood vessel (88) are determined, which time interval describes a characteristic transit time (τ) for the fluorophore in the portion (90.sub.i) of the blood vessel (88), in which a blood vessel model (M.sub.B.sup.Q) for the portion (90.sub.i) of the blood vessel (88) is specified, which blood vessel model describes the portion (90.sub.i) of the blood vessel (88) as a flow channel (94) having a length (L), having a wall (95) with a wall thickness (d), and having a free cross section Q. A fluid flow model M.sub.F.sup.Q for the blood vessel model (M.sub.B.sup.Q) is assumed, which fluid flow model describes a local flow velocity (122) at different positions over the free cross section Q of the flow channel (94) in the blood vessel model (M.sub.B.sup.Q), and a fluorescent light model M.sub.L.sup.Q is assumed, which describes a spatial probability density for the intensity of the remitted light at different positions over the free cross section Q of the flow channel (94) in the blood vessel model (M.sub.B.sup.Q), which light is emitted by a fluid, which is mixed with fluorophore and flows through the free cross section Q of the flow channel (94) in the blood vessel model (M.sub.B.sup.Q), when said fluid is irradiated with fluorescence excitation light. The blood volume flow (I.sub.BI) is determined as a fluid flow guided through the flow channel (94) in the blood vessel model (M.sub.B.sup.Q), which fluid flow is calculated from the length (L) and the diameter (D) of the portion (90.sub.i) of the blood vessel (88) and from the characteristic transit time (τ) for the fluorophore in t

A route selection assistance system enabling easy selection of a route of a living body lumen for delivering a medical instrument to a site within a living body via the living body lumen, a recording medium on which a route selection assistance program is recorded, and a route selection assistance method are disclosed. The route selection assistance system includes: a receiving section configured to receive an input of site information specifying a target site; an image obtaining section configured to obtain image information on a living body of a target patient; a route extracting section configured to extract a plurality of routes of a living body lumen; a ranking assigning section configured to assign rankings to the plurality of routes according to ease of delivery of the medical instrument and patient scores determined according to magnitude of a burden imposed on the target patient.

Methods for training a model for use in monitoring a health parameter in a person are disclosed. In an embodiment, a method involves monitoring a blood pressure of a person using a control blood pressure monitoring system, receiving control data that corresponds to the monitoring using the control blood pressure monitoring system, receiving stepped frequency scanning data that corresponds to radio waves that have reflected from blood in a blood vessel of the person, wherein the stepped frequency scanning data is collected through multiple receive antennas over a range of frequencies, generating training data by combining the control data with the stepped frequency scanning data in a time synchronous manner, and training a model using the training data to produce a trained model, wherein the trained model correlates stepped frequency scanning data to values that are indicative of a blood pressure of a person.

Fluorescence imaging with reduced fixed pattern noise is disclosed. A method includes actuating an emitter to emit a plurality of pulses of electromagnetic radiation and sensing reflected electromagnetic radiation resulting from the plurality of pulses of electromagnetic radiation with a pixel array of an image sensor to generate a plurality of exposure frames. The method includes applying edge enhancement to edges within an exposure frame of the plurality of exposure frames. The method is such that at least a portion of the plurality of pulses of electromagnetic radiation emitted by the emitter comprises one or more of electromagnetic radiation having a wavelength from about 795 nm to about 815 nm.

Systems and methods for aiding users in viewing, assessing and analyzing images, especially images of lumens and medical devices contained within the lumens. Systems and methods for interacting with images of lumens and medical devices, for example through a graphical user interface.

The present disclosure provides a body-insertion device for a body, which comprises a first moving unit for moving an image acquisition unit; an insertion unit; and a second moving unit for moving the insertion unit. The first moving unit comprises at least one of a 1-1 module for moving the image acquisition unit in a 1-1 direction, a 1-2 module for moving the image acquisition unit in a 1-2 direction, and a 1-3 module for moving the image acquisition unit in a 1-3 direction. The second moving unit comprises at least one of a 2-1 module for moving the insertion unit in a 2-1 direction, a 2-2 module for moving the insertion unit in a 2-2 direction, and a 2-3 module for moving the insertion unit in a 2-3 direction.

Display device for displaying sub-surface structures including acquisition apparatus to acquire images of at least part of the user's body or an object from acquisition signals defining a pre-determinable multispectral radiation band, display to make at least one image accessible to an operator in real time, a processor to coordinate the acquisition apparatus and display and extract, from the images, reference signals including first surface and/or sub-surface localization points defined by the part of the body or object, a database operationally connected to the processor including a plurality of models of sub-surface structures of the part of the body or object, each defining predetermined configurations of second localization points. The processor compares models with reference signals and selects one model having second localization points matching more with the first localization points, and the display makes accessible the model selected so the operator can see the sub-surface structure.

A hand-held vision sensor apparatus comprises a plurality of light sources, control activation elements and an image sensing array, encased within a housing such that the control activation elements are disposed at a user-accessible location on the housing. The housing further includes a pair of exit apertures for emitting illumination directed toward a medical specimen and an entrance aperture for capturing reflected light from the medical specimen. The light sources are disposed in alignment with the pair of exit apertures, and the image sensing array is aligned with the entrance aperture. The control activation elements are utilized to energize the light sources and control the functioning of the image sensing array. A computer port may be included and used to communicate command controls to the light sources, image sensing array and control activation elements in a manner that allows for a remotely-located technician to communicate with the hand-held vision sensor.