Methods and apparatus for utilizing multiple sources of physiologic data to enhance measurement robustness and accuracy. In one embodiment, phonocardiography or “heart sounds” data is used in combination with one or more other techniques (for example, impedance cardiography or ICG waveforms, and/or electrocardiography or ECG waveforms) to provide more accurate and robust physiological and/or hemodynamic assessment of living subjects. In one variant, the aforementioned methods and apparatus are used to improve ICG fiducial point (e.g., B, C and X point) detection and identification accuracy. Moreover, the new ICG fiducial points that may be clinically important may be identified using the disclosed methods and apparatus. In a further aspect, the invention discloses methods and apparatus for utilization of ICG and/or ECG waveform information to improve the identification and characterization of heart sounds (such as e.g., S1, S2, S3, or S4 heart 20 sounds), murmurs, and other such artifacts or phenomena.

A biological information analysis device including: an indicator extraction unit that is configured to extract, from time-series data regarding blood pressure waveforms consecutively measured by a sensor that is configured to be worn on a body part of a user and to be capable of non-invasively measuring a blood pressure waveform for each heartbeat, data regarding blood pressure waveforms corresponding to a period of time in which a change in blood pressure occurs, and extract an indicator that is related to the functionality of respiratory organs of the user, based on characteristics of the blood pressure waveforms corresponding to the period of time; and a processing unit that performs processing that is based on the indicator thus extracted.

A system for analyzing a patient using a transcutaneous sensor, having a base unit for attaching to the patient, an injector, releasably connectable to the base unit, for the transcutaneous insertion of the sensor into the patient, and a detection unit, releasably connectable to the base unit, for generating measurement data by the sensor. The base unit has a holding device which is configured to cooperate with the injector and detection unit such that, in a detection configuration with the detection unit arranged on the base unit, a contact pressure is applied to the sensor by the holding device for frictional fixing, and in an injection configuration with the injector arranged on the base unit, a lower contact pressure than in the detection configuration is applied to the sensor by the holding device.

Provided are tissue-mounted devices and methods for monitoring a thermal transport property (e.g., thermal conductivity, thermal diffusivity, heat capacity) of tissue, such as skin. The devices conformally mount to the tissue and have one or more thermal actuators and a plurality of sensors. The actuator applies heat to the tissue and the sensors to detect a spatio temporal distribution of a physiological tissue parameter or physical property resulting from the heating. This spatio temporal information may be correlated with a rate, velocity and/or direction of blood flow, the presence of a vascular occlusion, circulation changes due to inflammation, hydration level and other physiological parameters.

A wearable health monitoring device is disclosed. The device includes an attachment feature configured to engage with an attachment feature of an alignment element that is to be worn on the skin of a person, An RF front-end including a semiconductor substrate, at least one transmit antenna configured to transmit radio waves below the skin surface of the person, and a two-dimensional array of receive antennas configured to receive radio waves, the received radio waves including a reflected portion of the transmitted radio waves, wherein the semiconductor substrate includes circuits configured to generate signals in response to the received radio waves, a digital baseband system configured to generate digital data in response to the signals, wherein the digital data is indicative of a health parameter of the person, and a communications interface configured to transmit the digital data generated by the digital baseband system from the wearable health monitoring device.

An apparatus for measuring physiological parameters of a mammal subject includes a first sensor system and a second sensor system that are time-synchronized to each other and spatially separated. Each sensor system has a plurality of electronic components and a plurality of flexible and stretchable interconnects that are electrically connecting to different electronic components, and an elastomeric encapsulation layer at least partially surrounding the plurality of electronic components and the plurality of flexible and stretchable interconnects to form a tissue-facing surface and an environment-facing surface. The plurality of electronic components includes a sensor member for measuring at least one physiological parameter of the mammal subject, a system on a chip (SoC) having a microprocessor coupled to the sensor member for receiving data from the sensor member and processing the received data, and a transceiver coupled to the SoC for wireless data transmission and wireless power harvesting.

A biological information analysis device including: an indicator extraction unit configured to extract an indicator indicating a cardiac state, from data regarding blood pressure waveforms that are consecutively measured by a sensor that is configured to be worn on a body part of a user and to be capable of non-invasively measuring a blood pressure waveform for each heartbeat; and a processing unit configured to output the indicator extracted by the indicator extraction unit. The indicator extraction unit is configured to extract a value of a cardiac load indicator for each heartbeat, from the data regarding blood pressure waveforms, and calculate the indicator indicating the cardiac state, based on characteristics related to distribution of values of the cardiac load indicator corresponding to a plurality of heartbeats.

Aspects of the present disclosure relate to a self-mating fastener that includes a backing having a first side, and a rail element protruding perpendicularly from the first side of the backing. The rail element extends in a longitudinal direction along the backing. The rail element has a base portion attached to the first side of the backing and a cap portion distal from the backing. The cap portion has a cap width that is greater than a width of the base portion and the cap portion overhangs the base portion on opposing sides. The self-mating fastener includes an electrically conductive contact element proximate to the rail element.

An activity monitoring device, methods and computer readable media are provided. The activity monitoring device includes a housing configured for attachment to a body part of a user and a display screen attached to the housing. Further included is a first sensor disposed in the housing for capturing motion of the activity monitoring device when attached to the body part of the user and a second sensor disposed in the housing for sampling a heart rate of the user. Memory is disposed in the housing for storing the motion captured by the first sensor and the heart rate sampled by the second sensor. A processor is disposed in the housing and is configured to determine a physical state of the user during a period of time. For motion that is below a threshold the processor identifies the physical state to be a sedentary state and for motion that is at or above the threshold the processor identifies the physical state to be an active state. The processor is configured to reduce a rate at which to sample the heart rate of the user when the physical state of the user is identified to be the sedentary state during the period of time. The processor is configured to increase the rate at which the sampling of the heart rate of the user is processed when the physical state of the user is identified to be the active state during the period of time.

A method of manufacturing a component for a stretchable electronic device comprises providing a silicon wafer comprising a first surface and a second surface; applying a layer of a conductive metal onto at least a portion of the first surface of the silicon wafer; providing a stretchable silicone substrate having a first surface and a second surface; and plasma bonding at least a portion of the second surface of the silicon wafer to at least a portion of the first surface of the stretchable silicone substrate.