A device for occlusion of a left atrial appendage of a heart including an implantable occlusion apparatus including a radially expansible element adjustable between a contracted orientation for transluminal delivery and a deployed orientation configured to occlude the left atrial appendage, an elongated catheter member operably and detachably attached to the implantable occlusion apparatus and configured for transluminal delivery and deployment of the occlusion apparatus in the left atrial appendage, and an energy delivery module configured for adjustment from a contracted configuration, and a deployed configuration suitable for engagement with adjacent tissue to ablate the tissue. The energy delivery module is operably attached to the elongated catheter member proximally of the radially expansible element and configured to contact and ablate a wall of the left atrium surrounding an ostium of the left atrial appendage.

A pulmonary treatment system includes a compact configuration for delivery to an airway of a patient. An energy delivery system of the pulmonary treatment system delivers ultrasound energy to target nerve tissue in or along an airway wall of the airway radially outward from surface tissue to reduce airway resistance in a downstream airway. The pulmonary treatment system may protect tissue in the airway wall of the airway located between the target nerve tissue and the ultrasound energy delivery system by a coolant system that may also act as a coupling fluid for the emitted ultrasound energy.

A device includes a handle, an expandable structure including a plurality of splines extending from a proximal hub to a distal hub, a first electrode on a first spline of the plurality of splines, an outer tube extending from the handle to the proximal hub, and a shaft extending through the outer tube from the handle to the distal hub. The expandable structure has a collapsed state and a self-expanded state. The handle is configured to retract the shaft. Retracting the shaft may expand the expandable structure outward of the self-expanded state.

A catheter US transducer container and method of manufacture thereof including a housing, one or more cooling channels oriented longitudinally along a longitudinal axis of the container, a sealing cooling channel cover, one or more PE elements positioned on a floor of the cooling channel, the cooling channel having a trapezoid cross section at any point along the PE element.

Provided is a laser ablation catheter, including a laser optical fiber bundle, an adjustable head, an outer tube, an overtube and a connector. The outer tube wraps the laser fiber bundle. The adjustable head includes an adjustable stent, the adjustable stent is made of a shape memory material and is sleeved outside one end of the outer tube. The connector is connected to the other end of the outer tube, and the laser fiber bundle can be connected to a laser generator through the connector. The overtube is sleeved outside the adjustable stent for compressing the adjustable stent. At least one end of the adjustable stent is a movable end, and the movable end is slidingly connected to the outer tube. When the overtube is withdrawn, the movable end can provide conditions for the deformation of the adjustable stent.

Methods and system are provided for thermally-induced renal neuromodulation. Thermally-induced renal neuromodulation may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers. In some embodiments, parameters of the neural fibers, of non-target tissue, or of the thermal energy delivery element, may be monitored via one or more sensors for controlling the thermally-induced neuromodulation. In some embodiments, protective elements may be provided to reduce a degree of thermal damage induced in the non-target tissues. In some embodiments, thermally-induced renal neuromodulation is achieved via delivery of a pulsed thermal therapy.

A locator assembly (100) for determining a location of an arrhythmogenic foci (632) in or near a heart (101). The locator assembly (100) includes a device body (112) and a plurality of electrodes (102). The plurality of electrodes (102) receive electrical signals from the heart (101) to determine the location of the arrhythmogenic foci (632). The plurality of electrodes (102) can be coupled to the device body (112). At least two of the plurality of electrodes (102) can positioned circumferentially about the device body (112). The plurality of electrodes (102) can be positionable so that the plurality of electrodes (102) are in electrical communication with the heart (101).

A method for determining a location of an arrhythmogenic foci (632) in or near a heart (101) includes the steps of positioning a locator assembly (100) within the heart (101), the locator assembly (100) including a plurality of electrodes (102) that receive electrical signals from the heart (101), generating a first signal array (733) from the electrical signals received by the plurality of electrodes (102) to determine an actual location of the arrhythmogenic foci (632), artificially stimulating the heart (101) based on the actual location determined by the first signal array (733) to generate a second signal array (733), and confirming the actual location of the arrhythmogenic foci (632) by comparing the first signal array (733) with the second signal array (735). In some embodiments, the locator assembly (100) includes a plurality of bipolar electrodes (102).

A medical introducer includes an elongated tubular member having a proximal end, a distal portion, and a central lumen extending from the proximal end to a distal port in the distal portion. A frame structure is coupled to the distal portion of the elongated tubular member, where frame structure supports the distal portion of the elongated tubular member in a tapered shape and alternatively in a non-tapered shape. The elongated tubular member may include a rigid outer tube and a rigid inner tube carried in an interior lumen of the outer tube. The distal portion is typically a reinforced elastomeric tubular extension of the outer tube, and the reinforced elastomeric tubular extension may have a conical shape.

A septostomy device 10 with a cutting structure or means 140 and tissue capture mechanisms 240, 250 is disclosed, along with a medical procedure for using the device. The system 10 is configured in such a way as to create a permanent interatrial aperture in the heart, including creating a permanent interatrial hole and/or removing tissue.