A method of determining a pulsed field ablation waveform parameter for creating a desired lesion characteristic in cardiac tissue. The method of provides an electrosurgical generator configured to deliver electroporation pulses, the generator configured to: load predetermined waveform parameters (y.sub.i); load predetermined modeling data (x.sub.i); accept entry of a user inputted desired lesion characteristic (u.sub.i); and determine at least one corresponding pulsed field ablation waveform parameter based on (u.sub.i), (y.sub.i); and (x.sub.i).

Apparatus and associated methods relate to controlling electrical power of an electrotherapeutic signal that is provided to a biological tissue engaged by an electrosurgical instrument during a medical procedure. Electrical power—a product of a voltage difference across and an electrical current conducted by the engaged biological tissue—is controlled according to a therapeutic schedule. The electrotherapeutic schedule can be reduced or terminated in response to a termination criterion being met. In some examples, the termination criterion is a current characteristic, such as, for example, a decrease in current conducted by the engaged biological tissue. In some examples, the termination criterion is a biological tissue resistance characteristic, such as, for example, an increase in the biological tissue resistance that exceeds a predetermined delta resistance value.

There is disclosed a composition comprising one or more calcium salts, for use in a treatment or augmenting treatment of non-thermal ablation, the treatment comprising: administering an effective amount of said composition to the subject via a systemic route of administration; delivering non-thermal ablative energy to the target tissue. There is further disclosed ablation equipment for delivering non-thermal energy to treat target regions of tissue in organs, wherein a single power source is configured to generate electric sinusoidal voltage signals to energize each electrode of the equipment; and wherein the single power source is configured to supply at least first and second electrodes that are adjacent to each other on said ablation catheter, with sinusoidal electric voltage signals in phase or out of phase with each other to generate a unipolar electric field and/or a bipolar electric field for delivering the non-thermal energy to the tissue to be treated.

A method of determining a pulsed field ablation waveform parameter for creating a desired lesion characteristic in cardiac tissue. The method of provides an electrosurgical generator configured to deliver electroporation pulses, the generator configured to: load predetermined waveform parameters (y.sub.i); load predetermined modeling data (x.sub.i); accept entry of a user inputted desired lesion characteristic (u.sub.i); and determine at least one corresponding pulsed field ablation waveform parameter based on (u.sub.i), (y.sub.i); and (x.sub.i).

The disclosure relates to variable power modular electronic systems for generating unipolar and bipolar electrical pulses and associated uses thereof. In an embodiment, such a system includes one or more pulse generators for generating electrical pulses that can be connected in series; a charging circuit for charging the pulse generators; and a controller communicatively coupled to the pulse generators and the charging circuit. Advantageously, each pulse generator may include an AC/DC rectifier and a DC/AC inverter connected to said AC/DC rectifier in a bridge configuration to generate bipolar output electrical pulses or pulse trains. In addition, the charging circuit may include a DC/DC step-up converter connected to an indirect DC/AC inverter. The system provided in various embodiments of the disclosure also provides a great versatility for adaptation to various applications and high output voltage and current values.

A surgical generator configured to output a high-frequency alternating voltage to a surgical ultrasound instrument. An oscillator generates a driving oscillation for an inverter generating high-frequency voltage being for the surgical instrument. A matching-coil emulation device includes a correction device acting on the driving oscillation. The correction device includes a mixing unit and a feedback circuit, modifying the driving oscillation supplied to the inverter. An estimator calculates a virtual current which would flow in the emulated matching-coil if it were present, based on this and a measured output voltage an artificial phase shift is determined for steering of the oscillator. Thereby, the transfer function is reshaped mimicking that of a physical matching coil. Accordingly, a bulky matching coil that must be precisely tuned to the ultrasound instrument and restricts use of newer and different ultrasound instruments is no longer needed.

Apparatus and associated methods relate to controlling electrical power of an electrotherapeutic signal that is provided to a biological tissue engaged by an electrosurgical instrument during a medical procedure. Electrical power—a product of a voltage difference across and an electrical current conducted by the engaged biological tissue—is controlled according to a therapeutic schedule. The electrotherapeutic schedule can be reduced or terminated in response to a termination criterion being met. In some examples, the termination criterion is a current characteristic, such as, for example, a decrease in current conducted by the engaged biological tissue. In some examples, the termination criterion is a biological tissue resistance characteristic, such as, for example, an increase in the biological tissue resistance that exceeds a predetermined delta resistance value.

Apparatus and associated methods relate to controlling electrical power of an electrotherapeutic signal that is provided to a biological tissue engaged by an electrosurgical instrument during a medical procedure. Electrical power—a product of a voltage difference across and an electrical current conducted by the engaged biological tissue—is controlled according to a therapeutic schedule. The electrotherapeutic schedule can be reduced or terminated in response to a termination criterion being met. In some examples, the termination criterion is a current characteristic, such as, for example, a decrease in current conducted by the engaged biological tissue. In some examples, the termination criterion is a biological tissue resistance characteristic, such as, for example, an increase in the biological tissue resistance that exceeds a predetermined delta resistance value.

A method for ablating tissue by applying at least one pulse train of pulsed-field energy.

The method includes delivering a pulse train of energy having a predetermined frequency to cardiac tissue, the pulse train including at least 60 pulses, an inter-phase delay between Oμs and 5 μs, an inter-pulse delay of at least 5 μs, and a pulse width of 5 μs.

Apparatus and associated methods relate to controlling electrical power of an electrotherapeutic signal that is provided to a biological tissue engaged by an electrosurgical instrument during a medical procedure. Electrical power—a product of a voltage difference across and an electrical current conducted by the engaged biological tissue—is controlled according to a therapeutic schedule. The electrotherapeutic schedule can be reduced or terminated in response to a termination criterion being met. In some examples, the termination criterion is a current characteristic, such as, for example, a decrease in current conducted by the engaged biological tissue. In some examples, the termination criterion is a biological tissue resistance characteristic, such as, for example, an increase in the biological tissue resistance that exceeds a predetermined delta resistance value.