A non-invasive electrodynamic radiative electroporation system and method for safe in vivo delivery of specific radiant energy to physiologically inaccessible sites for selective destruction of biomolecular function of virions, particularly Covid-19 and its variants. The system and method applies a computer or like controller to generate, modulate, direct and deliver applied external electric fields from plural antennas to target tissues in the full respiratory tract, including lung microstructures, cardiovascular tissues and neuron networks. Electric fields exceeding a critical threshold-value interact with the virus lipid bilayer membranes, intra-membrane organelles, mRNA, and biomolecular scaffold assemblies, to destroy virion function through irreversible electroporation and electropermeabilization. Polarized electric fields are generated to provide force vectors in optimal dynamic angular distribution to the virion membrane surface and modulated within time-scales short compared to thermal transport characteristic times to effect the electroporation as an adiabatic process that preempts Joule heating of normal tissues.

The present disclosure relates to a multi-core optical fiber cable (MCF). In some embodiments, an MCF comprises a plurality of cores surrounded by a cladding and a coating surrounding the cladding, wherein a refractive index of one or more of the plurality of cores is greater than a refractive index of the cladding. The MCF further comprises a probe comprising a probe tip coupled with a distal end of the MCF and a lens located at a distal end of the probe tip. In some embodiments, the lens is configured to translate laser light from the distal end of the MCF to create a multi-spot pattern of laser beams on a target surface and a distal end of the MCF terminates at an interface with the lens.

There is provided a hair cutting device for cutting hair on a body of a subject, the hair cutting device comprising a light source for generating light at one or more specific wavelengths corresponding to wavelengths absorbed by one or more chromophores in or on hair; a cutting element that comprises an optical waveguide that is coupled at a first end to the light source to receive light, wherein a portion of a sidewall of the optical waveguide forms a cutting face for contacting hair; a light sensor that is coupled to the optical waveguide away from the first end, wherein the light sensor is for measuring the light level in the optical waveguide and for providing an output signal representing the measured light level; and a control unit that is coupled to the light source, and coupled to the light sensor to receive the output signal, wherein the control unit is configured to determine a measure of the amount of input light transmitted across the optical waveguide from the measured light level and an input light level at the first end of the optical waveguide; and to control the power of the light generated by the light source based on the determined measure.

A shaft assembly for a microwave ablation applicator which includes a shaft assembly and an antenna assembly located within the shaft assembly is disclosed. The shaft assembly comprises an elongate shaft which extends from a first end to a second end thereof, and which defines therein a hollow inner volume and a longitudinal axis of the antenna assembly, and an applicator tip mounted on the second end of the elongate shaft. The shaft assembly further includes a coolant delivery tube having a side wall which defines an elongate hollow interior.

An ultrasonic surgical instrument and method for identifying tissue state and energizing the surgical instrument includes an end effector having an ultrasonic blade and an RF electrode, a shaft assembly, a body, and a power controller. A first ultrasonic energy input is configured to be actuated from a first unactuated energy input state to a first actuated energy input state. A trigger input is configured to be actuated from an unactuated trigger input state to an actuated trigger input state. The power controller is operatively connected to the ultrasonic blade, the RF electrode, the first ultrasonic energy input, and the trigger input and configured to direct at least one of the ultrasonic blade or the RF electrode to be selectively driven according to a predetermined drive function based on the tissue impedance, the state of the first energy input, and the state of the trigger input.

A method of performing an electrosurgical procedure includes activating an electrode of a surgical instrument by applying an output power signal with a first energy output profile from a generator to the electrode. An induced electrical parameter of a conductive component is monitored via one or more sensors, the induced electrical parameter being associated with a predetermined electrical parameter threshold. The induced electrical parameter includes a parasitic energy loss. When the induced electrical parameter measured from a conductive component of the surgical instrument meets or exceeds the predetermined electrical parameter threshold during the operation, the output power signal of the generator is adjusted from a first energy output profile to a second energy output profile. The adjustment is operable to reduce the induced electrical parameter measured from the conductive component of the surgical instrument; and to reduce the parasitic energy loss without ceasing delivery of energy to the electrode.

The present invention is directed to a system and method for adaptive multivariate control for performing a radiofrequency (RF) ablation procedure with an energy delivery device. The system includes an energy source for delivering energy to a patient's body; one or more energy delivery devices; two or more sensors for measuring at least two factors related to an ablation procedure, respectively; and at least one processor. The method includes steps of: measuring at least two factors related to an ablation procedure; determining a first operating threshold based, at least in part, on a first factor; controlling an energy delivery device based on the first operating threshold to create a lesion at the target site within the patient; determining a second operating threshold based, at least in part, on a second factor; switching control of the energy delivery device from the first factor to the second factor; and controlling the energy delivery device based on the second operating threshold to create a lesion at the target site within the patient. The present invention is also directed to a RF probe configured to be used with the adaptive multivariate control system and method to perform RF ablation procedures.

An electrosurgical system includes an instrument, an RF energy generator, and two ground pads. The instrument includes an electrode and a conductive shield that is configured to collect a capacitive coupling current that is induced by the application of RF energy to tissue by the electrode. A first electrical lead couples the first ground pad with the ground return of the conductive shield and the generator. The ground return is configured to divert a first portion of the capacitive coupling current to the generator via the first electrical lead. A second electrical lead couples the second ground pad with the ground return of the conductive shield and the generator. The ground return is configured to divert a second portion of the capacitive coupling current to the generator via the second electrical lead. The first and second portions of the capacitive coupling current are substantially equal.

A laser system includes a first laser cavity to output a laser light along a first path, a first mirror to receive the laser light from the first laser cavity, and redirect the laser light along a second path that is different than the first path, a second mirror to receive the laser light from the first mirror, and redirect the laser light along a third path that is different than the first path and the second path, a beam splitter located at a first position on the third path, a beam combiner located at a second position on the third path; and a coupling lens assembly, the coupling lens assembly including a lens located at a third position on the third path, wherein the coupling lens assembly moves the lens in x-, y-, and x-directions.

An electrosurgical generator includes: a power supply configured to output a DC waveform; a power converter coupled to the power supply and configured to generate a radio frequency waveform based on the DC waveform; an active terminal coupled to the power converter and configured to couple to a first electrosurgical instrument and a second electrosurgical instrument; at least one sensor coupled to the power converter and configured to sense at least one property of the radio frequency waveform; and a controller coupled to the power converter. The controller is configured to: determine a first impedance associated with a first electrosurgical instrument and a second impedance associated with a second electrosurgical instrument based on the at least one property of the radio frequency waveform; and adjust at least one parameter of the radio frequency waveform based on the first impedance and the second impedance.