The invention provides a non-invasive device (100) for treatment of skin tissue using laser light, and it provides a method and a computer program product. The non-invasive device comprises a light emission system (110) for generating a first laser pulse (130) and a subsequent second laser pulse (150) at a predefined time delay (ΔT) after the first laser pulse. The non-invasive device further comprises an optical system (160) for focusing, in use, the first laser pulse and the second laser pulse at a treatment location (210) inside the skin tissue (200). The first laser pulse comprises a first power density, a first pulse duration and a first pulse energy for initiating a plasma (205) at the treatment location. The subsequent second laser pulse comprises a second power density being lower than the first power density and a second pulse duration being at least 10 times longer than the first pulse duration, and a second pulse energy higher than the first pulse energy for sustaining or intensifying the plasma initiated by the first laser pulse, whereby in use the first laser pulse and the second laser pulse together induce Laser Induced Optical Breakdown at the treatment location.

Various forms are directed to systems and methods for coagulation and dissection of tissue. A surgical instrument includes an end effector configured to seal and dissect tissue at a distal end thereof and a generator circuit that is configured to deliver energy to the end effector. A force sensor is in communication with the end effector and is configured to measure a force being applied to the tissue by the end effector. The energy delivered to the end effector is dynamic based on a determination of the type of tissue interacting with the end effector. The tissue type is determined based on a tissue coefficient that is calculated based on the measured force applied to the tissue by the end effector, the ultrasonic motion of the end effector, and a rate of heat generated by the end effector.

Dermatological systems and methods for providing a therapeutic laser treatment wherein the duration of a therapeutic laser pulse is based on one or more determinations of a surface temperature of the skin during the delivery of the pulse. Initiation of the therapeutic laser pulse may be based on sensed skin temperature during a cooling of the skin prior to initiation of the pulse.

Dermatological systems and methods for providing a therapeutic laser treatment using a handpiece delivering one or more therapeutic laser pulses to a target skin area along a first optical path, and sensing the temperature of the target skin area based on infrared energy radiating from the target skin area along a second optical path generally counterdirectional to the first office action, and sharing a common optical axis with the first optical path for at least a portion of the first and second optical paths. The handpiece may also provide contact cooling for a first skin area comprising the target skin area.

Methods and systems enabling the real-time monitoring of a light-induced procedure in a biological medium, and/or the acquisition of information related to this biological medium are provided. In some implementations, the light beam used for the procedure is modulated at a modulation frequency selected in view of the photoacoustic frequency response associated with the procedure. The photoacoustic feedback signal from the medium during the procedure is then monitored. This monitoring may involve filtering the photoacoustic feedback signal around the selected feedback modulation frequency. Ratiometric comparisons of the contribution of different frequencies to the photoacoustic feedback signal are also considered.

A surgical laser system (100) includes a first laser source (140A), a second laser source (140B), a beam combiner (142) and a laser probe (108). The first laser source is configured to output a first laser pulse train (144, 104A) comprising first laser pulses (146). The second laser source is configured to output a second laser pulse train (148, 104B) comprising second laser pulses (150). The beam combiner is configured to combine the first and second laser pulse trains and output a combined laser pulse train (152, 104) comprising the first and second laser pulses. The laser probe is optically coupled to an output of the beam combiner and is configured to discharge the combined laser pulse train.

A method for treating tissue includes applying an energy modality to tissue at an amplitude, measuring tissue impedance of the tissue, modulating application of the energy modality based on the measured tissue impedance, and ceasing application of the energy modality when a termination parameter is met.

A medical device includes a conductive body having a surface and a sensor conformally formed on the surface and including a piezoelectric polymer formed about a portion of the surface and following a contour of the surface. The piezoelectric polymer is configured to generate or receive ultrasonic energy. Electrical connections conform to the surface and are connected to an electrode in contact with the piezoelectric polymer. The electrical connections provide connections to the piezo electric polymer and are electrically isolated from the conductive body over a portion of the surface.

Dermatological systems and methods for providing a therapeutic laser treatment wherein the duration of a therapeutic laser pulse is based on one or more determinations of a surface temperature of the skin during the delivery of the pulse. Initiation of the therapeutic laser pulse may be based on sensed skin temperature during a cooling of the skin prior to initiation of the pulse.

Systems and methods for controlled sympathectomy procedures for neuromodulation are disclosed. A system for controlled micro ablation procedures is disclosed. A guidewire including one or more sensors or electrodes for accessing and recording physiologic information from one or more anatomical sites within the parenchyma of an organ as part of a physiologic monitoring session, a diagnostic test, or a neuromodulation procedure is disclosed. A guidewire including one or more sensors and/or a means for energy delivery, for performing a neuromodulation procedure within a small vessel within a body is disclosed.