Certain embodiments include a sensor system for measuring chlorine concentration in water. The sensor system can have a manifold including one or more flow passages for receiving fluid flow. The sensor system can have a probe for measuring chlorine concentration in fluid communication with a flow passage of the one or more flow passages of the manifold. The probe can have a probe body oriented to direct incoming fluid from one or more flow passages of the manifold toward an end of the probe body. The probe can have a plurality of flutes defined on an outer surface of the probe body. The flutes can be shaped and oriented to direct fluid from the end proximal to the electrodes, back toward the one or more flow passages of the manifold.

Systems and methods for assessing the oxidation status of a pharmaceutical preparations are provided herein. Methods provided herein are particularly useful for assessing pharmaceutical preparations comprising therapeutic proteins (e.g., therapeutic antibodies).

An oxidation-reduction substance equilibrium potential estimating method is provided, the method including: applying a voltage to an electrode contacting a sample containing an oxidation-reduction substance and sweeping the voltage; measuring a current flowing through the electrode; if an integrated value of the current becomes a value within a reference range, determining whether to sweep the voltage in an opposite direction to a sweep direction in the previous sweeping or to terminate sweeping of the voltage; if it is determined to terminate sweeping of the voltage, estimating an oxidation-reduction substance equilibrium potential at a value of the voltage; and if it is determined to sweep the voltage, sweeping the voltage in an opposite direction to a sweep direction in the previous sweeping.

An electrochemically active device is provided for collecting and retaining a blood sample with at least a two-electrode member connected to conductive tracks. A receptor with an integral receptor-membrane arranged on the two-electrode member, to receive non-electrochemically active heamoglobin bioanalyte and its complexes from red blood cells (RBC) of said blood sample, through a lysing agent and convert the non-electrochemically active heamoglobin bioanalyte and its complexes, into an electrochemically active bioanalyte and its electrochemically active complexes. The present invention also provides a point-of-care biosensor incorporated with the device of the present invention and method of measuring for the detection and quantitative measurement of concentrations of haemoglobin (Hb), glycated haemoglobin (GHb), methaemoglobin (MetHb) and myoglobin, in reduced volumes of blood samples, by determining redox current values in the reduced volumes of blood samples.

An electrochemically active device is provided for collecting and retaining a blood sample with at least a two-electrode member connected to conductive tracks. A receptor with an integral receptor-membrane arranged on the two-electrode member, to receive non-electrochemically active heamoglobin bioanalyte and its complexes from red blood cells (RBC) of said blood sample, through a lysing agent and convert the non-electrochemically active heamoglobin bioanalyte and its complexes, into an electrochemically active bioanalyte and its electrochemically active complexes. The present invention also provides a point-of-care biosensor incorporated with the device of the present invention and method of measuring for the detection and quantitative measurement of concentrations of haemoglobin (Hb), glycated haemoglobin (GHb), methaemoglobin (MetHb) and myoglobin, in reduced volumes of blood samples, by determining redox current values in the reduced volumes of blood samples.

This disclosure relates to a glucose-sensing electrode including a nanoporous metal layer and a maltose-blocking layer formed over the nanoporous metal layer. The nanoporous metal layer is capable of oxidizing both glucose and maltose without an enzyme specific to glucose or maltose in the glucose-sensing electrode. The maltose-blocking layer has porosity that permits glucose to pass therethrough and inhibits maltose from passing therethrough toward the nanoporous metal layer.

Embodiments described herein relate generally to compositions that include a synthetic redox-active receptor, and in particular to compositions that include a boronic acid based synthetic redox-active receptor which can electrochemically sense a target analyte in a sample solution. In some embodiments, a synthetic redox-active receptor can have a composition of formula I:

##STR00001##

wherein the variables L, L′, R, R′ n and X are described herein.

Apparatus (2) for sensing at least one parameter in water, which apparatus (2) comprises: (i) at least one electrode based sensor (4, 6) for sensing at least one parameter in water; and which apparatus (2) is such that: (ii) the electrode based sensor (4, 6) has a self-cleaning electrode; (iii) the electrode based sensor (4, 6) has a reference electrode; (iv) the self-cleaning electrode is stable in water; (v) the apparatus (2) is configured to operate by liberating chlorine from the water using a first waveform applied to the self-cleaning electrode; (VI) the apparatus (2) is configured to operate by liberating chlorine and oxygen from the water using a second waveform applied to the self-cleaning electrode; and (VII) the apparatus (2) is configured to preserve the condition of the reference electrode by periodically regenerating the reference electrode.

An electrochemical sensor comprising a boron doped diamond electrode formed of boron doped diamond material, an array of non-diamond carbon sites disposed on a sensing surface of the boron doped diamond electrode, electrochemically active non-diamond carbon surface groups bonded to the non-diamond carbon sites for generating a first redox peak at a first potential associated with dissolved oxygen and a second redox peak at a second potential which changes with pH, the first and second redox peaks being separated such that they do not overlap, an electrical controller configured to scan the boron doped diamond electrode over a potential range to generate at least said first redox peak, and a processor configured to give an electrochemical reading based on one or both of a position and an intensity of said first redox peak.

Methods of maintaining accuracy in the measurement of one or more parameters of industrial water in industrial water systems are provided. The methods include the use of physical and/or chemical procedures to prevent and/or remove deposition from one or more surfaces utilized in measurement of the one or more parameters. The deposition may be caused by, for example, corrosion, fouling, or microbiological growth.