A method for detecting an analyte in a sample is disclosed. The method includes providing a mobile device having a camera and an illumination source. A test strip having a test field with at least one test chemical for performing an optical detection reaction in the presence of the analyte is provided. The sample is applied to the test field. Several images of a region of the test strip are captured. The region includes at least part of the test field to which sample is applied. The images are captured before and after the sample is applied and with the illumination source turned on and off. The images captured are compared and differences in light intensities are determined. Analyte concentration is determined using the images captured and the determined light intensities.

A film for a microfluidic device is capable of bonding to a polydimethylsiloxane substrate having flow channels formed in a surface thereof, and also exhibiting stable hydrophilicity even under high temperature and high humidity conditions and having scratch resistance. When the film can be used as a microfluidic device, the film is bonded to a polydimethylsiloxane substrate having flow channels formed in a surface thereof to form a liquid-tight flow channels. The film including a base material and a hydrophilic coating, wherein the hydrophilic coating includes a (meth)acrylic resin and from 65 to 95 mass % of unmodified nanosilica particles based on a total mass of the hydrophilic coating.

A system and method for isolating target substrates includes a microfluidic chip, comprising a plurality of processing units, each processing unit comprising: an inlet port, a plurality of first chambers connected to the inlet port by a fluid channel, the fluid channel comprising a plurality of valves, a plurality of second chambers, each of the second chambers connected to a respective first chamber by a fluid channel, each fluid channel including a controllable blocking valve, and a plurality of respective outlet ports, each outlet port in fluid communication with a respective one of said second chambers and each outlet port including a blocking valve. A magnet is adjacent the microfluidic chip and is movable relative to the microfluidic chip. A valve control is capable of actuating certain ones of the controllable blocking valves in response to a control signal.

An integrated microfluidic systems and the method of fabrication is disclosed wherein various microfluidic devices fabricated onto substrates are bonded together either using an intermediary layer or not to facilitate the bonding process. The microfluidic ports on the microfluidic devices are aligned prior to bonding and the bonding results in leak-proof seals between the devices. Moreover, the fluidic capacitance using the present invention is eliminated thereby enabling microfluidic systems with far faster time responses. The example embodiments have a wide range of applications including medical, industrial control, aerospace, automotive, consumer electronics and products, as well as any application(s) requiring the use of multiple microfluidic devices.

The invention relates to a detector (100) which comprises at least one data output line (1) in connection with an electronic mechanism (200), at least one column input (2), which is connected to the detector outlet column of a gas chromatography device and to which the sample from which the chromatography data is to be obtained is sent, at least one gas inlet (3) so that preferably nitrogen gas can enter, at least one gas outlet (4) for gas to exit from the detector (100), at least one gas mixing area (5) for mixing the gas sent from the column inlet (2) and preferably N2 gas sent from the gas inlet (3), at least one radioactive measurement chamber (13), at least one gas inlet line (6) for transferring the gas to said radioactive measurement chamber (13), at least one radioactive or non-radioactive light emitting source (9), preferably at least one shielding material (10) that prevents gases from exiting the shielding area, at least one gas outlet line (11) for the gas to exit from said radioactive measurement chamber (13), at least one outlet chamber (14) preferably to allow the gas to exit, at least one scintillator crystal (7) over which the electrical signal is formed with the current applied by the first power source (17) and which interacts with the gases which are mixed in the said measurement chamber (13), wherein the scintillator crystal allows the formation of an optical signal by emitting photons which have specific emission wavelengths as a result of the gases with which it interacts and of the current applied to the photodetector (19) unit, or without the application of current, has an uncoated outer surface or is coated with a conductive coating (8), the outer surface of which has a predetermined thickness in addition to the optical signal for obtaining the electrical signal, preventing the corrosion which will occur thereon and separating the signal of low energy electrons from the optical signal, and at least one fixing apparatus (12) that carries the data of the light coming from the fiber optic cable inside said scintillator crystal (7) or with said photodetector (19) placed on the surface thereof, fixes the scintillator crystal (7) and transfers the electrical data from the scintillator crystal (7) to the data output line (1).

The invention relates to a detector (100) which comprises at least one data output line (1) in connection with an electronic mechanism (200), at least one column input (2), which is connected to the detector outlet column of a gas chromatography device and to which the sample from which the chromatography data is to be obtained is sent, at least one gas inlet (3) so that preferably nitrogen gas can enter, at least one gas outlet (4) for gas to exit from the detector (100), at least one gas mixing area (5) for mixing the gas sent from the column inlet (2) and preferably N2 gas sent from the gas inlet (3), at least one radioactive measurement chamber (13), at least one gas inlet line (6) for transferring the gas to said radioactive measurement chamber (13), at least one radioactive or non-radioactive light emitting source (9), preferably at least one shielding material (10) that prevents gases from exiting the shielding area, at least one gas outlet line (11) for the gas to exit from said radioactive measurement chamber (13), at least one outlet chamber (14) preferably to allow the gas to exit, at least one scintillator crystal (7) over which the electrical signal is formed with the current applied by the first power source (17) and which interacts with the gases which are mixed in the said measurement chamber (13), wherein the scintillator crystal allows the formation of an optical signal by emitting photons which have specific emission wavelengths as a result of the gases with which it interacts and of the current applied to the photodetector (19) unit, or without the application of current, has an uncoated outer surface or is coated with a conductive coating (8), the outer surface of which has a predetermined thickness in addition to the optical signal for obtaining the electrical signal, preventing the corrosion which will occur thereon and separating the signal of low energy electrons from the optical signal, and at least one fixing apparatus (12) that carries the data of the light coming from the fiber optic cable inside said scintillator crystal (7) or with said photodetector (19) placed on the surface thereof, fixes the scintillator crystal (7) and transfers the electrical data from the scintillator crystal (7) to the data output line (1).

Since the measurement start timings for a plurality of specimens in different test fields deviate from one another, the measurement results are not coordinated, leading to a delay in reporting. When determining an order for measuring a newly recognized specimen using an automated analysis device capable of performing measurements in a plurality of test fields, the measurement order for specimens waiting to be measured is changed to minimize the time difference between measurement result output timings for a plurality of specimens for the same patient, with reference to specimen information such as urgent test information, a measurement completion time, and an earliest measurement completion time for other specimens, relating to the patient's other specimens having the same patient number in the specimen information.

A sample handling system for handling samples is disclosed. The sample handling system comprises sample holders, each receives a sample container; a sample transport device for moving the sample holders; a control unit for controlling functionality of the sample handling system, and a monitoring system for monitoring the samples during movement. The monitoring system comprises a camera module for continuously capturing images of a part of the sample transport device, wherein the camera module is at a distance from the sample transport device such that the camera module has a free field of view to the sample transport device, and a processor for processing the captured images and determining an item of information about the sample transport device and/or the sample container and/or the sample from the captured images. The control unit retrieves the item of information from the processor. The controlling is based on the retrieved item of information.

The invention provides a method for preparing an expanded cell or tissue sample suitable for microscopic analysis. Expanding the sample can be achieved by binding, e.g., anchoring, key biomolecules to a DMAA-TF polymer network and swelling, or expanding, the polymer network, thereby moving the biomolecules apart as further described herein. As the biomolecules are anchored to the polymer network isotropic expansion of the polymer network retains the spatial orientation of the biomolecules resulting in an expanded, or enlarged, sample.

A detection chip, a method of using a detection chip and a reaction system are provided. The detection chip includes a first substrate, a micro-chamber definition layer and a heating electrode. The micro-chamber definition layer is located on the first substrate and defines a plurality of micro-reaction chambers. The heating electrode is located on the first substrate and closer to the first substrate than the micro-chamber definition layer, and configured to release heat after being energized. The heating electrode includes a plurality of sub-electrodes, orthographic projections of the plurality of micro-reaction chambers on the first substrate overlap with orthographic projections of at least two of the plurality of sub-electrodes on the first substrate, and the at least two of the plurality of sub-electrodes have different heating values per unit time after being energized.