A microfluidic device includes first and second substrate structures. The first substrate structure has a first substrate surface configured to receive one or more droplets. A plurality of electrodes configured to apply an electric field to the droplets. The second substrate structure has a second substrate surface facing the first substrate surface and spaced apart from the first substrate surface to form a fluid channel. The microfluidic device has a first heating element adjacent to the first substrate structure and disposed on an opposite side of the first substrate surface, and a second heating element adjacent to the second substrate structure and disposed on an opposite side of the second substrate surface. The microfluidic device further includes one or more temperature sensors disposed adjacent to the fluid channel between the first substrate structure and the second substrate structure.

Provided are an active droplet generating apparatus capable of controlling a droplet size, a method of controlling a droplet size using the same, and a self-diagnosis apparatus for diagnosing generation of a droplet, the active droplet generating apparatus including: a disposable microchannel upper plate; a multifunctional lower plate separated from the disposable microchannel upper plate and configured to be permanently used separately from the disposable microchannel upper plate; a functional polymeric film provided on a lower surface of the upper plate; a negative pressure forming means; and a flow velocity control device configured to adjust the droplet size to a desired size by receiving, by feedback, the voltage value measured by the droplet measuring electrode and controlling flow velocities of the oil and the sample, thereby controlling the droplet size in a feedback control manner by quickly and accurately measuring the droplet size using a capacitance impedance technique.

Disclosed is a genetic diagnosis chip. The genetic diagnosis chip includes one or more unit processing parts, wherein the unit processing part includes a pretreatment unit that loads a sample and performs a pretreatment process on a target material in the loaded sample, and a distribution unit which is located radially outward from the pretreatment unit and in which the target material pretreated through the pretreatment unit is distributed and detection of the distributed target material is performed, the pretreatment unit includes a sample loading unit that loads the sample, and a capture channel which captures the target material from the loaded sample, and the sample loading unit is formed on the capture channel.

A wearable sensor for monitoring an external bodily fluid includes a sensor thread, a wick, a substrate, and a communication interface all of which are disposed on a substrate. The wick wicks the external bodily fluid to a functionalized region of the thread. The communication interface transmits, to an external device, data indicative of what the sensor thread has measured in said external bodily fluid. The external device can then carry out real-time analysis or storage.

Microfluidic devices, kits systems and methods are provided for high throughput phenotypic separation of magnetically labelled cell samples. The devices and methods can be used for example to sort cells based on level of target marker and to sort screen cells, such as CRISPR screen cells and other screens with a large number of target cells, to isolate target cells and putative genetic modifiers.

Microfluidic devices, method for making and using same are disclosed. The microfluidic device can be made by applying a reagent in liquid form into a sample treatment site within a substrate base. The substrate base has hydrophilic properties bordering a flow channel, and has an application site, the sample treatment site and an analytical site. The flow channel is sized and configured so as to draw a sample applied into the application site to the analytical site through the sample treatment site by capillary action. The reagent is freeze-dried within the sample treatment site.

Material processing apparatus, systems, methods, and products are described. An example of a material processing apparatus includes a holding member, a base, a tensioning member, an actuator, and a first inner member. The holding member defines a holding member passageway. The base is attached to the holding member. The tensioning member is partially disposed within the holding member passageway. The tensioning member defines a tensioning member passageway. The tensioning member is moveable relative to the holding member between a first position and a second position. The actuator is attached to the tensioning member and is moveable in a first direction and a second direction. Movement of the actuator results in movement of the tensioning member between its first position and second position. The first inner member is adapted to be disposed within the tensioning member passageway.

Tissue sample management systems include a central network, a medical professional system, and a pathology lab system for processing a tissue sample in a matrix having a sectionable code. At least the pathology lab system includes at least one imaging device, and the central network is configured to process images from the at least one imaging device to identify and record at least the sectionable code of the matrix. Methods for tissue sample processing include providing a matrix having a sectionable code and measurement marks, the matrix for receiving a tissue sample, and identifying the sectionable code from an image taken of the tissue sample in the matrix. Tissue sample-receiving matrices include a sectionable alphanumeric code or bar code, a tissue sample receptacle, and measurement marks formed along a sidewall thereof. The matrices include one or more proteins and one or more lipids.

In one example in accordance with the present disclosure, a system is described. The system includes a fluidic die to advance across an ejection path relative to a substrate. The fluidic die includes a channel to contain a portion of a sample fluid, a sensor to detect passage of a particle within the sample fluid into the channel, and an ejection device. The ejection device is to eject the particle. The system also includes a controller. The controller identifies discrete locations along the ejection path as waste sites as the fluidic die advances along the ejection path. This is done by 1) classifying the particle as a target particle or a non-target particle, 2) upon identification of a target particle, ejecting the target particle to a target site of the substrate, and 3) upon identification of a non-target particle, ejecting the non-target particle to a waste site.

Method of assaying for an analyte in a sample, and kits for performing the assay.