A microchannel chip with which channel deformation does not occur even when high-temperature and high-pressure sterilization treatment is performed and with which strong joining performance of substrates is maintained; and a method for manufacturing the same are provided. A microchannel chip comprising: a channel substrate having a microchannel formed on at least one surface thereof; a lid substrate; and a joining layer joining the channel substrate and the lid substrate, wherein the channel substrate, the lid substrate, and the joining layer are each formed of a cycloolefin polymer, a glass-transition temperature Tg.sub.s1 of a cycloolefin polymer forming the channel substrate, a glass-transition temperature Tg.sub.s2 of a cycloolefin polymer forming the lid substrate, and a glass-transition temperature Tg.sub.2 of a cycloolefin polymer forming the joining layer have relationships: Tg.sub.s1>Tg.sub.2; and Tg.sub.s2>Tg.sub.2, and the joining layer has a thickness within a specific range.

A portable biosensor for detecting and quantifying a target molecule in a biological sample and method of use include a biosensor fabricated with a recognition layer with an imprinted polymer, an electrode electrically coupled to the recognition layer, and a logic circuit that may include a processor and non-transitory memory with computer executable instructions embedded thereon, wherein the imprinted polymer is shaped to have a profile that substantially matches a profile of the target molecule, such that the target molecule can form-fit and bind to the imprinted polymer, thus changing an electrical property of the polymer layer that may be detected to identify the presence of the target molecule.

An impedance measurement system for detecting an analyte in a sample is disclosed. The system includes first, second, and third electrodes, wherein at least a portion of the third electrode is positioned between the first and second electrodes, means for generating an electromagnetic field between the first and second electrodes, means for electrically controlling the third electrode, wherein the third electrode modifies the electromagnetic field, and a processor for detecting a presence of the analyte in the sample, based at least in part on a property of the electromagnetic field.

Provided is an electrical circuit for electrochemical measurement of a solution, said electrical circuit comprising: a voltage generation circuit; an operational amplifier that has an output (OUT), a non-inverting input (+IN), and an inverting input (−IN), wherein the output (OUT) is connected to a counter electrode (CE) in contact with the solution, the inverting input (−IN) is connected to a reference electrode (RE) in contact with the solution, and the non-inverting input (+IN) is connected to the voltage generation circuit; a capacitor that is connected between the output (OUT) and inverting input (−IN) and has a capacitance of 1 μF or greater; and a current measurement circuit that is connected to a working electrode (WE) in contact with the solution.

A system for diagnostic testing may include a meter for performing a diagnostic test on a sample applied to a test media, the meter having a housing and an interface for receiving a signal representing coding information, and a container configured to contain test media compatible with the meter, the container having a coding element associated therewith. Additionally, the system may provide a mechanism for removing the meter from an interconnected test container and reattaching it to a new container using on-container coding methods that can recalibrate the meter for the new container of test strips.

A system and method for rapid detection of viable microorganisms (e.g., pathogens) in liquid media suspensions utilizes at least two electrodes in electrical communication with a suspension (e.g., liquid media possibly containing microorganisms). Electrical response to an electrical pulse in a short initial time window (e.g., no longer than a time required to attain 95% (or another threshold percentage) of a steady state electrical response value after a change in state of the pulse) permits bulk electrical response of the suspension between the electrodes to be determined before electrical response signals are dominated by double layer formation at surfaces of the electrodes. Pulse application and detection of electrical response to a change in state of a pulse may be repeated over time, with changes in such response being useful to detect microorganism proliferation in a bulk suspension.

The present application relates to a method for detecting and monitoring the level of thyroid hormones in an individual and a device for carrying out the same.

An analysis method using a microchip which is provided with a capillary flow path, and a sample reservoir connected to the capillary flow path, in which the capillary flow path is filled with a first liquid for electrophoresis, and a second liquid containing a sample is stored in the sample reservoir, and including a pressurization process in which the first liquid is pressurized into the capillary flow path from a side of the capillary flow path that is opposite from the side connected to the sample reservoir, and a separation process in which a voltage is applied between the sample reservoir storing the second liquid and the capillary flow path filled with the first liquid, such that components in the sample contained in the second liquid move in the capillary flow path and the components are separated in the capillary flow path.

Methods and systems for control of solid phase peptide synthesis are generally described. Control of solid phase peptide synthesis involves the use of feedback from one or more reactions and/or processes (e.g., reagent removal) taking place in the solid phase peptide synthesis system. In some embodiments, a detector may detect one or more fluids flowing across a detection zone of a solid phase peptide synthesis system and one or more signals may be generated corresponding to the fluid(s). For instance, an electromagnetic radiation detector positioned downstream of a reactor may detect a fluid exiting the reactor after a deprotection reactor and produce a signal(s). In some embodiments, based at least in part on information derived from the signal(s), a parameter of the system may be modulated prior to and/or during one or more subsequent reactions and/or processes taking place in the solid phase peptide synthesis system. In some embodiments, the methods and systems, described herein, can be used to conduct quality control to determine and correct problems (e.g., aggregation, truncation, deletion) in reactions (e.g., coupling reactions) taking place in the solid phase peptide synthesis system.

A multi-analyte sensor device is disclosed. The multi-analyte device is a handheld device that includes a replaceable sensor. In one embodiment, the replaceable sensor includes a plurality of electrodes coated with one or more different molecular imprinted polymer (MIP) coatings for measuring concentrations of target analytes. The replaceable sensor is configured to be attached or detached from the device one or more times.