A structure includes a first layer having a recess. The structure further includes an intermediate layer contacting the first layer and a contact-free biosensor aligned above the recess. The portion of the intermediate layer that is positioned along the recess separates the contact-free biosensor from the recess.

A microchannel device that can suppress a flow of a test solution produced between microchannels is provided. The microchannel device includes an opening for receiving a test solution that is to be injected therethrough, a main channel, a plurality of microchannels, a reservoir, an opening, and a gas permeable membrane. The plurality of microchannels include a first group and a second group. The microchannels included in each of the first group and the second group are arranged as being aligned in a direction of an X axis when the microchannel device is viewed in a plan view, and the first group and the second group are arranged as being aligned in a direction of a Y axis orthogonal to the direction of the X axis.

The present technology relates to systems and associated methods for measuring properties of particles in a solution. In one or more embodiments, a particle measurement system is configured to generate a reference signal, communicate the reference signal across a plurality of resistors and overlapping pairs of electrodes that define detection regions for particulates traveling through a microchannel, and measure various properties of the particles based on detecting changes in the communicated reference signal.

The present invention relates generally to the field of disposable assay test devices, particularly for use in point-of-care assays. The invention further relates to the use of such devices, including kits comprising such devices, to facilitate the accurate measurement of the levels of sepsis in the blood using electronic measurements.

Devices, apparatuses, methods, and computer program products are provided for hemorrhage detection. An example sensing device for hemorrhage detection includes a blood selective layer that includes a permeable film and an iron selective conductive circuit supported by the permeable film. The sensing device further includes a controller operably coupled with the blood selective layer. The controller is configured to supply a current to the iron selective conductive circuit, determine an impedance of the iron selective conductive circuit responsive to blood received by the blood selective layer, and determine an amount of blood received by the blood selective layer based upon the determined impedance. The controller may further compare the determined impedance with an alert threshold and generate an alert signal in an instance in which the determined impedance satisfies the alert threshold.

A system for real-time detecting cancer by analyzing unprocessed blood. The system includes a sensor, an electrical stimulator-analyzer connected to the sensor, and a processing unit connected to the electrical stimulator-analyzer. The sensor includes three electrodes including a working electrode, a counter electrode, and a reference electrode configured to be put in contact with an unprocessed blood sample. The processing unit is configured to perform a method. The method includes applying a set of voltages between the reference electrode and the working electrode utilizing the stimulator-analyzer, measuring a produced set of currents between the counter electrode and the working electrode utilizing the stimulator-analyzer, measuring a level of a ratio of low-density neutrophils (LDNs) to high-density neutrophils (HDNs) in the unprocessed blood sample by measuring a maximum current of the measured set of currents, and detecting a cancer disease if the measured maximum current is less than a threshold value.

A sensing device is provided. The sensing device includes a transistor, a disposable electrode, and a remote electrode. The transistor includes an extended gate, source and drain. The remote electrode is configured to receive a reference voltage. The disposable electrode is coupled between the transistor and the remote electrode. The disposable electrode includes a proximal end and a distal end. The proximal end of the disposable electrode is coupled to the extended gate of the transistor. The distal end of the disposable electrode is coupled to the remote electrode. The disposable electrode is adapted to load a cell and receive a membrane potential of the cell. The disposable electrode provides a gate voltage to the extended gate based on the change of the membrane potential and the reference voltage. The transistor provides different transistor currents at the drain based on the change of the gate voltage.

This invention is directed to non-invasive devices and methods to detect electrochemically active molecules in a fluid sample of a subject.

A method for configuring a device to determine a concentration of an analyte uses a plurality of m fluid samples, each having a corresponding known analyte concentration. The method includes, for each sample: generating an output signal from the sample; recording values of the signal over time; and modelling a subset of the values of the signal using n basis functions to obtain n coefficients. Each coefficient is associated with a corresponding basis function, the n basis functions and n coefficients representing the signal for the subset. The method also includes performing a statistical analysis of the m×n coefficients and corresponding known analyte concentrations to determine a set of n parameters from which an analyte concentration can be estimated based on a set of n coefficients obtained for a sample for which the analyte concentration is unknown; and storing the set of n parameters in a memory of a device.

The invention relates to a method for monitoring the evolution of an indicator used to indicate physical state comprising the body fat of a subject and/or the muscular mass of a subject, comprising periodical steps of analysis of a biological fluid for the quantification of a biomarker representative of a metabolic activity comprising lipolysis, myolysis, lipogenesis or myogenesis, and of transmission of the result of said analysis to a remote connected apparatus.