Methods are provided for end users of diagnostic measurement procedures to prepare quality controls having desired analyte recoveries, estimate recoveries of quality controls already prepared, and compare estimated and measured recoveries. To prepare a quality control containing a particular analyte, a desired recovery of a measurement procedure for the analyte can be scaled by a correlation factor to obtain a target nominal concentration of the analyte in the quality control. Alternatively, the nominal concentration of an analyte in a quality control can be scaled by a correlation factor to obtain a predicted recovery of a measurement procedure for the analyte. The correlation factors can be based on recovery data previously obtained using the measurement procedure and optionally one or more reference procedures, and can be calculated using regression analysis of these data. Each quality control can be prepared by dissolving a number of solid beads containing the analyte(s) of interest in a volume of base matrix.

The present invention relates to the field of treating iron deficiency with IV iron carbohydrate complexes such ferric carboxymaltose, monitoring or identifying subjects to determine their eligibility for being administered said IV iron carbohydrate complexes, and combining said IV iron carbohydrate complexes with additional drugs in order to mitigate or reduce side effects induced by said IV iron carbohydrate complexes.

A method for analyzing a urine sample includes binding a plurality of analytes from a urine sample to an adsorbent; and analyzing the plurality of analytes using a molecular analyzer to detect evidence of at least one water soluble vitamin and at least one fat soluble vitamin in the urine sample. The method can also include analyzing the urine sample using the molecular analyzer to detect a thyroid analyte selected from the group consisting of 3-5-Diiodo-L-Thyronine (LT2), 3-3-5-L-Thyroxine (LT3) and L-Thyroxine (LT4). Prior to analyzing the analytes, the method can include one or more of: washing the solid phase extraction column with a methanol solution after the step of binding; eluting the plurality of analytes from the adsorbent with at least one of (i) a mixture of isopropanol and methanol, and (ii) a mixture of ethyl acetate and methanol, to form an eluate; evaporating the eluate; and reconstituting the evaporated eluate with a mixture of methanol and water.

A method for analyzing a urine sample includes binding a plurality of analytes from a urine sample to an adsorbent; and analyzing the plurality of analytes using a molecular analyzer to detect evidence of at least one water soluble vitamin and at least one fat soluble vitamin in the urine sample. The method can also include analyzing the urine sample using the molecular analyzer to detect a thyroid analyte selected from the group consisting of 3-5-Diiodo-L-Thyronine (LT2), 3-3-5-L-Thyroxine (LT3) and L-Thyroxine (LT4). Prior to analyzing the analytes, the method can include one or more of: washing the solid phase extraction column with a methanol solution after the step of binding; eluting the plurality of analytes from the adsorbent with at least one of (i) a mixture of isopropanol and methanol, and (ii) a mixture of ethyl acetate and methanol, to form an eluate; evaporating the eluate; and reconstituting the evaporated eluate with a mixture of methanol and water.

The present application relates to a method for detecting and monitoring the level of thyroid hormones in an individual and a device for carrying out the same.

The present application relates to a method for detecting and monitoring the level of thyroid hormones in an individual and a device for carrying out the same.

Provided are methods for determining the amount of thyroglobulin in a sample using various purification steps followed by mass spectrometry. The methods generally involve purifying thyroglobulin in a test sample, digesting thyroglobulin to form peptide T129, purifying peptide T129, ionizing peptide T129, detecting the amount of peptide T129 ion generated, and relating the amount of peptide T129 ion to the amount of thyroglobulin originally present in the sample.

Provided are methods for determining the amount of thyroglobulin in a sample using various purification steps followed by mass spectrometry. The methods generally involve purifying thyroglobulin in a test sample, digesting thyroglobulin to form peptide T129, purifying peptide T129, ionizing peptide T129, detecting the amount of peptide T129 ion generated, and relating the amount of peptide T129 ion to the amount of thyroglobulin originally present in the sample.

Methods are provided for end users of diagnostic measurement procedures to prepare quality controls having desired analyte recoveries, estimate recoveries of quality controls already prepared, and compare estimated and measured recoveries. To prepare a quality control containing a particular analyte, a desired recovery of a measurement procedure for the analyte can be scaled by a correlation factor to obtain a target nominal concentration of the analyte in the quality control. Alternatively, the nominal concentration of an analyte in a quality control can be scaled by a correlation factor to obtain a predicted recovery of a measurement procedure for the analyte. The correlation factors can be based on recovery data previously obtained using the measurement procedure and optionally one or more reference procedures, and can be calculated using regression analysis of these data. Each quality control can be prepared by dissolving a number of solid beads containing the analyte(s) of interest in a volume of base matrix.

Methods are provided for end users of diagnostic measurement procedures to prepare quality controls having desired analyte recoveries, estimate recoveries of quality controls already prepared, and compare estimated and measured recoveries. To prepare a quality control containing a particular analyte, a desired recovery of a measurement procedure for the analyte can be scaled by a correlation factor to obtain a target nominal concentration of the analyte in the quality control. Alternatively, the nominal concentration of an analyte in a quality control can be scaled by a correlation factor to obtain a predicted recovery of a measurement procedure for the analyte. The correlation factors can be based on recovery data previously obtained using the measurement procedure and optionally one or more reference procedures, and can be calculated using regression analysis of these data. Each quality control can be prepared by dissolving a number of solid beads containing the analyte(s) of interest in a volume of base matrix.