Methods and systems for Nuclear Magnetic Resonance (NMR) spectra of samples having unresolved peaks are described. The methods and systems allow for the creation nuclear spin singlet states in nearly-equivalent spin pairs, for example, using continuous spin-locking with a nutation frequency matched to the coupling strength between spins.

An embodiment in accordance with the present invention provides a new MRI method to image the buildup of exchange transfer processes from nuclei in mobile solute molecules in tissue via another molecule (e.g. solvent such as water). The pulse sequence can detect Chemical Exchange Saturation Transfer (CEST), relayed Nuclear Overhauser Enhancement (rNOE) CEST, and selective induced exchange transfer processes. Further, the proposed MRI pulse sequence involves acquiring two or more images with a difference in waiting period (delay) after a radiofrequency excitation, saturation pulse, or series of such pulses. This produces a series of exchange transfer images sensitive to the speed of transfer of changes in magnetization. Subtracting two images or fitting a time series produces maps with minimum interference from direct water saturation and from semi-solid magnetization transfer and other fast exchanging protons.

The present invention provides techniques for non-invasive measurement of blood related parameters based on NMR (nuclei) relaxation techniques carried out using a relatively low constant magnetic field in the range of 0.15 to 0.5 Tesla. A plurality of electromagnetic excitation pulse sequences having relatively low radiofrequencies are applied over a living tissue placed in the magnetic field and blood related parameters of the examined subject are determined using a plurality of nuclear spin echo signals received from the tissue in response to the applied excitation sequences, thereby allowing to improve the accuracy of the obtained signals and substantially reducing the time duration of the process.

The invention relates to a system and methods for measuring and determining a characteristic of veneer with NMR spectroscopy in the serial production of veneer, wherein the measurement is taken as online measurement steps from veneer, the measurement steps comprising: creating a magnetic field with two magnets located on the opposite sides of veneer relative to the veneer and opposite to each other, and exposing hydrogen protons in water to the magnetic field for a time required by excitation of protons either by dimensioning the magnetic field in the travel direction of veneer to a sufficient range with respect to excitation of protons relative to the movement speed of the veneer or by moving the magnet and the magnetic field created by it in the travel direction of the veneer during the measurement, and determining veneer moisture distribution based on said amplitude and relaxation time of the backward signal.

This polarization-transfer apparatus, which induces hyperpolarization with respect to a precursor containing .sup.13C nuclei or .sup.15N nuclei, has a microfluidic device in which the precursor is guided in a magnetic shield such that the strength of the magnetic field acting on the precursor monotonically decreases from approximately 1 ?T to zero magnetic field, and then the precursor is guided in the magnetic shield such that the strength of the magnetic field acting on the precursor monotonically increases from zero magnetic field to approximately 1 ?T.

Technologies applicable to SNMR pulse sequencing are disclosed, including SNMR acquisition apparatus and methods, SNMR processing apparatus and methods, and combinations thereof. SNMR acquisition may include transmitting SNMR pulse sequences according to any of a variety of techniques. SNMR processing may include combining SNMR from a plurality of pulse sequences.

Compositions and methods useful in connection with magnetic resonance imaging are provided. Metabolites hyperpolarized by dynanic nuclear polarization are used as reporter molecules in nuclear magnetic resonance (NMR) spectroscopy to study metabolic pathways and diagnose disease states. The reporter molecules include hyperpolarized glutamine and hyperpolarized acetate. The invention includes the reporter molecules, compositions including the reporter molecules in pharmaceutically acceptable carriers, methods for studying metabolic pathways that include introducing one or more of the reporter molecules to a mammalian subject and imaging a target substance using NMR spectroscopy, and kits useful in studying metabolic pathways that incorporate one or more of the reporter molecules and instructions for their use.

Methods and systems for Nuclear Magnetic Resonance (NMR) spectra of samples having unresolved peaks are described. The methods and systems allow for the creation nuclear spin singlet states in nearly-equivalent spin pairs, for example, using continuous spin-locking with a nutation frequency matched to the coupling strength between spins. The invention relates generally to the field Nuclear Magnetic Resonance (NMR). Nuclear magnetic resonance (NMR) spectroscopy can be used as a tool for determining the chemical structure and/or geometry of a molecule in a sample. In many samples, however, resonance frequencies of different nuclei fully or partially overlap, which makes chemical identification of molecule(s) in a sample difficult or impossible.

Described are methods and apparatus, referred to as temperature-lock, which can control and stabilize the sample temperature in an NMR spectrometer, in some instances with a precision and an accuracy of below about 0.1 K. In conventional setups, sample heating caused by experiments with high-power radio frequency pulses is not readily detected and is corrected by a cumbersome manual procedure. In contrast, the temperature-lock disclosed herein automatically maintains the sample at the same reference temperature over the course of different NMR experiments. The temperature-lock can work by continuous or non-continuous measurement of the resonance frequency of a suitable temperature-lock nucleus and simultaneous adaptation of a temperature control signal to stabilize the sample at a reference temperature value. Inter-scan periods with variable length can be used to maintain the sample at thermal equilibrium over the full length of an experiment.

Methods of fingerprinting a specific molecule in a composition using nuclear magnetic resonance (NMR) is disclosed. The disclosed NMR methods provide several modifications and improvements over existing NMR techniques. In some embodiments, the methods include applying a cycle of signal processing steps, including applying a radio frequency (RF) pulse, applying a gradient pulse having a pulse length less than or equal to 1000 ?s, and applying a water suppression technique (WET). In some embodiments, the methods further include repeating the cycle for at least 3 times to acquire an enhanced signal of the composition. In some embodiments, the methods further include fingerprinting the specific molecule based on the enhanced signal of the composition.