Medical devices and methods for placing a bifurcated stent into a bifurcating blood vessel are described herein. Also, described herein are methods for treating aorto-iliac occlusive disease. The bifurcated stent can be mounted onto a catheter comprising at least two balloons by mounting a first branch stent of the bifurcated stent onto a first balloon and a second branch stent of the bifurcated stent onto a second balloon, and a main body of the bifurcated stent onto the first balloon and second balloon.

Reversibly deformable corneal implants for replacing excised corneal tissue, the implants including an optical portion and an anchoring portion having different mechanical properties from each other.

A prosthetic valve includes a frame and a flow control component. The frame has an aperture extending through the frame about a central axis. The flow control component is mounted within the aperture and is configured to permit blood flow in a first direction approximately parallel to the vertical axis from an inflow end to an outflow end of the flow control component and to block blood flow in a second direction, opposite the first direction. The frame has an expanded configuration with a first height along the central axis, a first lateral width along a lateral axis perpendicular to the central axis, and a first longitudinal length along a longitudinal axis perpendicular to the central axis and the lateral axis. The frame has a compressed configuration with a second height less than the first height and a second lateral width less than the first lateral width.

A clot capture device for restoring blood flow to a vessel occluded by a clot including a plurality of struts formed by interconnected fibers terminating in a distal end. An open proximal end includes a clot capture space larger than the distal end. The device includes an expanded deployed configuration and a retracted delivery configuration whereby the device is advanceable through a microcatheter across the clot, and the device is configured such that upon deployment the device is deployed distal to the clot and then withdrawn to remove the clot from the vessel.

An implantable vein frame is contemplated in which two ring members are rigidly joined in spaced axial alignment via one or more interconnecting members. One of the one or more interconnecting members defines a protruding region that acts upon the implant placed within the frame and/or the vein that the vein frame is placed within to define a sinus region. The implant is placed within and scaffolded by the vein frame, and the vein frame is subsequently inserted within a vein via a venotomy, or interposed between two vein segments via vein interposition graft. The vein frame acts to support the structural integrity of the implant, and to scaffold and anchor the implant in place with the vein.

Some embodiments described herein include a heart valve replacement system that may be delivered to a targeted native heart valve site via one or more delivery catheters. In some embodiments, a prosthetic heart valve of the system includes structural features that securely anchor the prosthetic heart valve to the site of the native heart valve. Such structural features can provide robust migration resistance. In particular implementations, the prosthetic heart valves occupy a smaller delivery profile, thereby facilitating a smaller delivery catheter for advancement to the heart.

Systems and methods for mitral valve repair having a docking station and a valve implant. The docking station is an anchoring device having a helix structure. The valve implant is made of an expandable frame and a valve, and is radially expandable to a diameter that is at least the same as an expanded diameter of the anchoring device. The method of delivering the docking station and valve implant is performed by inserting the components through device delivery catheters.

A heart valve repair system includes a delivery sheath and an implant that includes a frame having a surface configured to contact an upstream surface of a native heart valve. First and second gripping members are coupled to the frame and each (1) includes first and second arms and (2) is configured to clamp a respective native leaflet. The implant is disposed in the sheath in a delivery state in which the frame defines a wall fully surrounding a central longitudinal axis of the implant. The distal end of the wall defines a distal opening of the frame. The distal end of the wall is disposed proximally to the entire first tissue-engaging surface of each of the gripping members and proximally to the entire second tissue-engaging surface of each of the gripping members. Other embodiments are also described.

Embodiments of a prosthetic heart valve are disclosed. An implantable prosthetic valve can include an annular frame having an inflow end, an outflow end and a central longitudinal axis extending from the inflow end to the outflow end. The valve can include a support layer, where a first portion of the support layer extends circumferentially around the central longitudinal axis along an outer surface of the frame and a second portion of the support layer extends circumferentially around the central longitudinal axis axially beyond the inflow end of the frame. The valve can further include a valvular structure, where at least a portion of the valvular structure is connected to the second portion of the support layer and is unsupported by the frame.

An ophthalmic pinhole prosthetic and a method of fabricating the same. The ophthalmic pinhole prosthetic comprises an annular portion, an inner perimeter, and an interior light transmitting portion. The annular portion may be optically opaque or at least partially optically opaque. The inner perimeter may include surface modifications configured to reduce or substantially eliminate diffraction of light compared to an ophthalmic pinhole prosthetic without the surface modifications. The interior light transmitting portion may be located within the annular portion and function to allow passage of light to interact with a retina.