The present disclosure relates to an optical measurement probe for the detection of measurement values correlating with a measurand of a measuring medium, including a probe housing having at least one immersion region structured to be immersed in the measuring medium, a radiation source arranged in the probe housing, a radiation receiver arranged in the probe housing, and an indicator chamber formed in the probe housing and sealed via a membrane arranged in the immersion region of the probe housing, wherein an indicator is contained in the indicator chamber, the indicator including an AIE-active substance dissolved in an indicator solution or in an indicator gel, which AIE-active substance is a substance formed from species, molecules, complexes or clusters whose luminescence efficiency is increased via formation of aggregates containing the species.

A device and method for rapid assessment of sensor response times as the sensor is rapidly switched between two or more calibration fluids discharged from a multi-fluid jet nozzle. The novel method includes exposing the sensor to a first calibration fluid and then rapidly exposing it to a second calibration fluid without removing the sensor from the fluid phase. The sensor's output is then assessed to determine its response time. This method is simpler and less expensive than other methods and allows improved precision timing of the change in calibration fluids without changing flow velocity or exposure to other media or viscosities. An embodiment of the novel device is a dual-fluid jet nozzle that ejects two distinct jets of calibration fluid at the same velocity through a single nozzle discharge aperture divided by a sharply-edged boundary wall.

The present disclosure relates to a protective device for a sensor unit of an optochemical sensor for determining or monitoring at least one analyte present in a medium, including at least one protective substance for protecting the sensor unit against a physical and/or chemical alteration caused by at least one substance contained in the medium, and an at least partially media-permeable functional layer, where the protective device, in a region facing towards the medium, can be attached to the sensor unit or applied to the sensor unit. The present disclosure further relates to an optochemical sensor having a protective device according to the present disclosure.

A method and apparatus for analyzing a biologic fluid sample for at least one target analyte is provided. The method includes providing an analysis chamber having at least one optically responsive chemical sensor (ORCS), sample and calibration fluid regions, and at least one fluid separator that separates the sample and calibration fluid regions. A first portion of each sensor is disposed in the sample fluid region and a second portion of each sensor is disposed in the calibration fluid region. The ORCS is configured to optically respond in the presence of the target analyte and when interrogated with one or more predetermined wavelengths of light. The method further includes disposing at least one calibration fluid having target analyte in a known or ascertainable concentration in the calibration fluid region, and disposing the biologic fluid sample in the sample fluid region. The sample is analyzed using a first optical response from the first portion of the ORCS and a second optical response from the second portion of the ORCS.

Methods and systems disclosed herein may be operable to detect a presence or absence of an analyte in human tissue. An example method includes operating one or more light sources to illuminate a plurality of optodes with excitation light. Each optode is embedded in tissue at a respective location. The excitation light causes the optodes to emit emission light and the optodes are sensitive to at least one analyte such that the emission light emitted by the optodes is indicative of a presence or absence of at least one analyte in the tissue. An optical filter arrangement includes for each optode in the plurality of optodes a corresponding set of one or more optical filters. The method includes obtaining detector information from a detector arrangement optically coupled to the optical filter arrangement, and detecting the at least one analyte based on the detector information.

The invention relates to a sensing unit (1) comprising a housing (2) that has a first housing opening which can be oriented towards a medium (M) to be analyzed, and a second housing opening on which at least one means for detachably rigidly connecting to a sensor shaft or sensor housing are arranged, or may be arranged, on the inner and/or outer side; at least one sensor element (3) that is arranged in the housing (2) and comprises indicators and, optionally, indicator protectors, said sensor element (3) having a first side facing the first housing opening and a second side lying opposite the first housing opening; and at least one protector element (4) which is arranged in the region of the first housing opening between the at least one sensor element (3) and the medium (M) which surrounds the sensing unit (1), particularly in the region of said housing opening, such that the sensor element (3) does not come into direct contact with the medium (M).

Optics collection and detection systems are provided for measuring optical signals from an array of optical sources over time. Methods of using the optics collection and detection systems are also described.

An optochemical sensor for determining a measurement signal, which correlates with a concentration of an analyte of a measuring fluid, comprises: a sensor cap including a sensor spot, wherein the sensor spot contains at least one analyte-sensitive indicator dye and a state description indicator which reflects the aging state of the sensor spot; a radiation source to radiate excitation radiation onto the sensor spot and to excite a luminescence of the indicator dye; a radiation receiver to receive reception radiation emitted by the sensor spot; and a sensor circuit electrically connected to the radiation source and the radiation receiver and configured to control the radiation source and to generate, based on an intensity of luminescence and/or a phase angle of luminescence, a measurement signal representing the concentration of the analyte in the measuring fluid in contact with the sensor spot.

A sensor can include a nanostructure in a housing configured to contact a sample.

System and method for detecting and measuring chemical perturbations in a sample. The system and method are useful for non-invasive pH monitoring of blood or blood products sealed in storage bags.