A system for obtaining a measurement of a species of interest. The system includes one or more reference regions, a sensor region, an exciter unit, a detector unit and a processing unit. The exciter unit exposes first and second chemical transducers in the reference and sensor regions, respectively, to an excitation light while they are exposed to reference environments and an analyte, respectively. The detector unit measures responses of the first and the second chemical transducers to the excitation light. The processing unit determines a compensation for aging of the first chemical transducer from a discrepancy between the measurements of the responses of the first chemical transducer and reference responses. The processing unit applies the compensation for aging to the measurement of the response of the second chemical transducer to obtain the measurement of the species of interest in the analyte.

Presented herein are methods, systems, and apparatus for single analyte detection or multiplexed analyte detection based on amplified luminescent proximity homogeneous assay (alpha) technology, but using hollow polymer fiber optics doped with acceptor bead dye (e.g., thioxene, anthracene, rubrene, and/or lanthanide chelates) or donor bead dye (e.g., phthalocyanine) that carry a signal generated by the dopant via singlet oxygen channeling.

An improved luminescent optode is disclosed that is capable of conducting a self-test to determine the quality of the optode's measurement of the concentration of a quenching molecule in a fluid, along with a method for conducting the self-test.

A system and method for detecting an analyte includes a waveguide configured to receive a narrow-band laser signal; and a sorbent material covering an analyte detection region of the waveguide, wherein the sorbent material is configured to sorb the analyte and bring the analyte to an evanescent field of the waveguide, and wherein Raman scattering is produced by an interaction of the evanescent field and the analyte sorbed in the sorbent material along the analyte detection region of the waveguide, and the waveguide is further configured to collect the Raman scattering along the analyte detection region of the waveguide, wherein the collected Raman scattering indicates a type of the analyte.

The invention relates to an optical sensor element, comprising indicators (2), selected from luminescence-active means that are of the same type or different, and indicator protectors (1), and to a sensor, comprising at least one such sensor element, an energy source that excites the luminescence emission of the indicators, and a detector unit, wherein the sensor element or sensor is suitable for detecting molecular oxygen in a gaseous or liquid medium and/or for determining the molecular oxygen content of a gaseous or liquid medium and at least one layer of the sensor element bearing the indicator protectors is designed in such a way that the diffusion rate of the molecular oxygen formed on the indicator protectors by means of the reduction of strong oxidants back into the medium is greater than the diffusion rate of molecular oxygen from the medium in the direction of the at-least-one layer bearing the indicator molecules.

A system for obtaining a measurement of a species of interest. The system includes one or more reference regions, a sensor region, an exciter unit, a detector unit and a processing unit. The exciter unit exposes first and second chemical transducers in the reference and sensor regions, respectively, to an excitation light while they are exposed to reference environments and an analyte, respectively. The detector unit measures responses of the first and the second chemical transducers to the excitation light. The processing unit determines a compensation for aging of the first chemical transducer from a discrepancy between the measurements of the responses of the first chemical transducer and reference responses. The processing unit applies the compensation for aging to the measurement of the response of the second chemical transducer to obtain the measurement of the species of interest in the analyte.

The invention relates to an optical sensor element, comprising indicators, selected from luminescence-active means that are of the same type or different, and indicator protectors, and to a sensor, comprising at least one such sensor element, an energy source that excites the luminescence emission of the indicators, and a detector unit, wherein the sensor element or sensor is suitable for detecting molecular oxygen in a gaseous or liquid medium and/or for determining the molecular oxygen content of a gaseous or liquid medium and at least one layer of the sensor element bearing the indicator protectors is designed in such a way that the diffusion rate of the molecular oxygen formed on the indicator protectors by means of the reduction of strong oxidants back into the medium is greater than the diffusion rate of molecular oxygen from the medium in the direction of the at-least-one layer bearing the indicator molecules.

An oxygen sensor has an oxygen sensitive fluorescent material including an oxygen sensitive dye and an oxygen insensitive dye, the oxygen sensitive dye and an oxygen insensitive dye being fluorophores; and a large diameter optical fiber. The large diameter optical fiber includes a first end and a second end. The large diameter optical fiber is configured to transit photons and transmit emissions from one or more of the fluorophores upon excitation thereof. The oxygen sensitive fluorescent material is located on the first end of the large diameter optical fiber.

Systems and indicators for determining the presence or absence of specific environmental, exposure, or biological conditions are provided. Indicators include a plurality of sensors, each sensor independently having a biological or chemical sensing modality to detect one or more analytes of interest. Analytes of interest include nucleic acids (e.g., DNA, RNA, etc.), proteins, peptides, and other amino acid chains and may come from a subject or the microbiome of a subject. The signals from the plurality of sensors may be processed to provide a readily understandable readout concerning a health condition or predisposition of a subject, such as cancer and exposure to coronavirus. The signals from the plurality of sensors may be colorimetric (e.g. a color change in response to the presence or absence of an analyte), and a plurality of colorimetric signals may be combined to provide a readily understandable colorimetric output. Indicators may be wearable.

The present invention relates a sensor assembly for analyzing a complex fluid sample. The sensor assembly comprises a sample chamber for holding the complex fluid sample, the sample chamber being defined by chamber walls and having an inlet and an outlet defining a direction of flow from the inlet towards the outlet for fluid handling in the sample chamber. The sample chamber comprises a first sample space and a second sample space. The second sample space comprises a porous membrane sensor element for detecting an analyte in a continuous fraction of the complex fluid sample. The porous membrane sensor element comprises a porous membrane with a front side defining a sensor surface for contacting the fluid sample, the sensor surface facing towards the second sample space, the porous membrane comprising pores extending from respective openings at the sensor surface into the porous membrane. The pores are configured with regard to the analyte for diffusive fluid communication with the second sample space. The sample chamber further comprises a flow-perturbing element arranged upstream of the second sample space, between the first sample space and the second sample space.