A system for preparing solutions for chromatography application is disclosed. The system comprises a T-joint for preparing a buffer solution by mixing at least one first solution and a second solution. The T-joint receives the second solution from a solution supply unit connected to the T-joint. Further one or more low pressure pumps supply the one or more first solutions into the T-joint. The high pressure pump collects the buffer solution and delivers it to a chromatography apparatus.

A liquid chromatograph mass spectrometer specifying a location where a flow path is clogged and recovering in a short time. The liquid chromatograph mass spectrometer includes a first flow path passing through a separation column, a second flow path not passing through the separation column, a mass spectrometry unit on the downstream side of the first and second flow paths and analyzes a sample that has passed through the first flow path, a first valve for connecting any one of the first and second flow paths to the mass spectrometry unit, and a controller for controlling driving of the first valve, connecting the first flow path to the mass spectrometric unit, comparing the measured value of the mass spectrometric unit with a predetermined threshold value, and connecting the second flow path to the mass spectrometry unit when it is determined to be abnormal.

Tests of channels of a system as a whole can be easily performed without adding a complicated mechanism. A liquid feeding part includes a liquid feeding channel to feed a mobile phase, a drainage channel to release pressure in the liquid feeding channel, an analysis channel that discharges the mobile phase into the sample introduction part, and a channel switching valve that selectively connects the liquid feeding channel to one of the drainage channel and the analysis channel. The channel switching valve is configured to be able to provide a tight stopper state in which the liquid feeding channel is connected to neither the analysis channel nor the drainage channel.

A fluid sample system includes a control system that operates in the hazardous area and controls one or more valves and optionally receives outputs from one or more transducers and optionally one or more sensors. The fluid sample system includes components that operate in a hazardous area and includes a control system that operates in the hazardous area and that controls one or more electrical devices. The control system communicates across a barrier with a system on a safe side of the barrier with as few as two intrinsically safe couplings including a single pneumatic coupling and a communication link coupling. The control system includes an intrinsically safe voltage boost circuit.

An analyzing device includes a splitting part for causing fluid containing a sample component to flow separately in a first flow passage and a second flow passage; an analyzing column provided on the first flow passage for separating the sample component from the fluid; a first back pressure regulating valve corresponding to a first pressure controlling unit for controlling a pressure in the first flow passage; and a second back pressure regulating valve corresponding to a second pressure controlling unit for controlling a pressure in the second flow passage, wherein flow rate of the fluid in the first flow passage and flow rate of the fluid in the second flow passage are controlled based on a ratio of the pressure in the first flow passage to the pressure in the second flow passage.

An analyzing device includes a splitting part for causing fluid containing a sample component to flow separately in a first flow passage and a second flow passage; an analyzing column provided on the first flow passage for separating the sample component from the fluid; a first back pressure regulating valve corresponding to a first pressure controlling unit for controlling a pressure in the first flow passage; and a second back pressure regulating valve corresponding to a second pressure controlling unit for controlling a pressure in the second flow passage, wherein flow rate of the fluid in the first flow passage and flow rate of the fluid in the second flow passage are controlled based on a ratio of the pressure in the first flow passage to the pressure in the second flow passage.

One end of carrier gas channel, purge gas channel and split gas channel is connected to sample gasification chamber. The other end of carrier gas channel, purge gas channel, and split gas channel is connected to a flow rate control mechanism in the form of carrier gas flow rate control block, purge gas flow rate control block and split gas flow rate control block respectively. Carrier gas flow rate control block, purge gas flow rate control block and split gas flow rate control block constitute a flow rate control unit. This reduces the possibility of leakage of gas to the outside and admixture of impurities from the outside in the flow rate control mechanism.

Provided are methods for determining the apolipoprotein E (ApoE) phenotype in a sample by mass spectrometry; wherein the ApoE allele(s) present in the sample is determined from the identity of the ions detected by mass spectrometry. In another aspect, provided herein are methods for diagnosis or prognosis of Alzheimer's disease or dementia.

Systems for use with liquid chromatography for provision of continuous flow or gradient flow in connection with two pumps providing mobile phase to a valve.

The present disclosure relates to a computer-implemented method for analyzing a product stream of a chemical reaction. The method includes withdrawing a portion of the product stream of the chemical reaction from a reactor, the portion of the product stream having a volume of less than about 200 μL. The method further includes mixing the portion of the product stream with a diluent to produce a sample and then transferring the sample to a liquid chromatography device. A measured chemical profile is then developed, via the liquid chromatography device, which can be used for process monitoring or real time decision making. In some embodiments, the method can include adjusting a reaction condition in the reactor based on differences between the measured chemical profile and a desired chemical profile.