A method is disclosed comprising providing a biological sample on a swab, directing a spray of charged droplets onto a surface of the swab in order to generate a plurality of analyte ions, and analysing the analyte ions.

In an electrochemical imaging method of, by applying voltages between working electrodes arranged in a measurement area and a counter electrode and causing the working electrodes to perform a redox reaction by giving and reception of electrons to and from a plurality of measurement target substances generated or consumed by a sample in an electrolytic solution to measure currents that flow through the individual electrodes, imaging images of density distributions of the measurement target substances based on distributions of the currents in the measurement area, the working electrodes are arranged in the measurement area in a manner of being arranged uniformly in each of a plurality of working electrode groups, each of the working electrode groups comprising a plurality of working electrodes, and in a manner of being mutually mixed; applied voltages specified for the working electrode groups, respectively, are simultaneously applied between the working electrodes and the counter electrode; any two working electrode groups among the plurality of working electrode groups are mutually different in at least any of the determined voltage, presence/absence of a molecular modification of an electrode surface and a species of the molecular modification; and based on the individual distributions of the currents in the measurement area in the working electrode groups, the images of density distributions of the measurement target substances are acquired by simultaneous measurements.

Methods and devices for monitoring the viability of a biofilm comprising Pseudomonas Aeruginosa bacteria are provided by detecting pyocyanin. The invention relates to electrochemical methods and devices that offer a simple and inexpensive alternative for immediate identification of bacterial infection due to the presence of Pseudomonas aeruginosa. In some embodiments, an inexpensive, disposable electrochemical sensor can be used to rapidly screen for the presence of P. aeruginosa in clinical wound effluent samples.

A method of analysis using mass spectrometry and/or ion mobility spectrometry is disclosed comprising: (a) using a first device to generate smoke, aerosol or vapour from a target in vitro or ex vivo cell population; (b) mass analysing and/or ion mobility analysing said smoke, aerosol or vapour, or ions derived therefrom, in order to obtain spectrometric data; and (c) analysing said spectrometric data in order to identify and/or characterise said target cell population or one or more cells and/or compounds present in said target cell population.

A device (1) for detecting the bacterial charge in a liquid or semi-liquid food product comprises a main containment body (2), an analysis chamber (3), located inside the containment body (2) and designed to contain a certain quantity of product to be examined, one or more heating means (4) designed to heat the product inside the analysis chamber (3), at least one temperature sensor (5) designed to monitor the temperature of the product inside the analysis chamber (3) and sensor means (6) designed to detect the impedance in the product inside the analysis chamber (3). The analysis chamber (3) has an elongate shape and extends along a principal axis (3a), while the one or more heating means (4) are symmetrical about a plane at right angles to the principal axis (3a).

A new sensitive cell biomarker of solid tumors is identified in blood. This biomarker can be used to determine presence of solid tumors, rapid determination of treatment response, early detection of cancer, early detection of cancer recurrence, and may be used to determine therapy.

The present invention relates to methods for controlling chromatographic processes in real-time via mass measurement utilizing a variable pathlength spectrophotometer.

Methods and devices for detecting a target agent of interest, e.g., a pathogen, in a sample are described herein. In some embodiments, a sensor is provided that can include a substrate, a graphene layer disposed on a surface of said substrate, and a protein bound to said graphene layer. The protein can be capable of binding to one or more target agents of interest, e.g., pathogens, etc. The binding of the protein to the one or more target agents of interest can generate a change in an electrical property of the graphene layer.

Systems and methods to integrate electrical sensors comprising parallel electrodes into microfluidic devices that are manufactured using soft lithography are disclosed herein. With minimal fabrication complexity, more uniform electric fields than conventional coplanar electrodes are produced. The methods disclosed are also more suitable for the construction of complex electrical sensor networks in microfluidic devices due to greater layout flexibility and provide improved sensitivity over conventional coplanar electrodes.

Systems, methods and devices for detecting a presence of an analyte in a fluid sample are described herein. The devices include a microfluidic module having a microfluidic channel configured to receive the fluid sample at an inlet thereof and direct the fluid sample towards an outlet thereof. The devices also include an image sensor positioned removably abutting the microfluidic module. The image sensor is positioned laterally between the inlet and the outlet of the microfluidic channel and below a lower surface of the microfluidic channel. The image sensor is communicatively coupled to a processor that is configured to receive signal data from the image sensor. The devices also include a light source configured to direct light through the fluid sample and towards the image sensor as the fluid sample passes through the microfluidic channel. The image sensor receives the light and outputs the signal data to the processor.