The present invention provides a pipette tip, which can be used in in-vitro diagnostics, in particular in the diagnostic testing of body fluids, such as in coagulation testing. The Pipette tip contains two constituents in a spatially separated manner. The present invention furthermore provides a method of performing such diagnostics, e.g. coagulation analysis, and to the use of the pipette tip in such diagnostic testing.

The present invention provides a coated article, which can be used in in-vitro diagnostics, in particular in the diagnostic testing of body fluids, such as in blood coagulation testing. The coated article is made of a polymer material and coated with a polymer material, which may be the same or different. The present invention furthermore provides a method of preparing such a coated article and a method of performing such diagnostics, e.g. coagulation analysis.

Methods and devices for evaluating coagulation are described, including methods and devices for detecting an anticoagulant agent or a coagulation abnormality. In various embodiments, the methods and devices of the invention measure coagulation of a sample in response to a gradient of one or more coagulation factors. These responses can be evaluated to accurately profile coagulation impairments of the sample, including the presence of anticoagulant medication. In various embodiments, the invention provides point-of-care or bedside testing with a convenient, microfluidic device that can be used by minimally trained personnel.

Coagulation assays for a point-of-care platform is disclosed. For example, the disclosure provides methods of measuring viscoelastic properties in a droplet on a microfluidics device, including using electrowetting-mediated droplet operations on the microfluidics device. In some embodiments, a microfluidics point-of-care platform may be used for assaying and/or monitoring coagulation of a blood sample. The disclosure provides a system, digital microfluidics device, and methods for measuring coagulation of a blood sample. In various embodiments, the disclosure provides a microfluidics device including droplets subject to manipulation by the device wherein droplet movement is used to characterize coagulation of a blood sample.

A blood coagulation system analysis apparatus includes: an estimating unit that estimates a characteristic regarding an inhibitor of a blood coagulation factor on a basis of a comparison result between a first result regarding a blood coagulation inhibition ability of the inhibitor of the blood coagulation factor and a second result regarding the blood coagulation inhibition ability, the first result being obtained on a basis of at least one electrical characteristic of a first blood sample to which the blood coagulation factor is added, and the second result being obtained on a basis of at least one electrical characteristic of a second blood sample, wherein the second blood sample contains either a concentration of the blood coagulation factor which is different from the concentration of the blood coagulation factor in the first blood sample or does not contain any blood coagulation factor.

An apparatus is for use in viscoelastic analysis, for example in coagulation testing of sample liquids, such as blood and/or its elements. In the apparatus for use in viscoelastic analysis, the rotating means are provided below the cup, pin and cup receiving element. A capacitive detection means and temperature control devices may be used in the apparatus for use in viscoelastic analysis. A method of performing viscoelastic analysis, e.g. coagulation analysis, on a sample may use the devices and apparatuses.

This determination method comprises the steps consisting of providing a reaction vessel (2) containing a blood sample (33) and a ferromagnetic ball (11) placed on a raceway (9) provided in the bottom of the reaction vessel (2), subjecting the ball (11) to a magnetic field so as to move the ball along the raceway (9) in an oscillatory motion, exposing the blood sample to an incident light beam (36), detecting a light beam (38) transmitted through the reaction vessel (2) and coming from the incident light beam (36) in such a way as to provide a measurement signal, carrying out a first processing of the measurement signal in such a way as to provide a first signal representative of the variation of at least one physical quantity representative of the movement of the ball (11), carrying out a second processing of the measurement signal in such a way as to provide a second signal representative of the variation of at least one optical property of the blood sample, determining a first value of the coagulation time of the blood sample from the first signal, and determining a second value of the coagulation time of the blood sample from the second signal.

A bracket, a thrombelastography device, and a support system are disclosed. The bracket comprises: a fixed support part (101), a movable support part (102), and a connection part (103). The connection part comprises a first fixing connection member (1031) and a second fixing connection member (1032). The first fixing connection member is fixedly connected to the fixed support part; the second fixing connection member is fixedly connected to the movable support part; the first fixing connection member is connected to the second fixing connection member in point contact fashion, such that the first fixing connection member and the second fixing connection member can rotate relative to each other; the movable support part is fixedly connected to a supported object; when driven by the supported object, the movable support part rotates relative to the fixed support part by means of the point contact between the first fixing connection member and the second fixing connection member. The thrombelastography device comprises a rotational shaft and a bracket. The rotational resistance to the supported object when it rotates can be reduced.

A coagulation test device for measuring clotting time and clot characteristics of a whole blood sample under different hemostatic conditions. Results of the test are used as an aid in management of patients with coagulopathy of unknown etiology in order to help the physician determine appropriate clinical action to arrest bleeding in a patient.

A sample collection and testing device for analyzing blood is provided that includes a controller, a fluid flow pathway, a pump configured to move fluid through the fluid pathway, and an optical fluid measurement element configured to measure a light intensity of the fluid in the fluid flow pathway. The controller is configured to: start the pump to move a blood sample in the fluid flow pathway, receive a signal from the optical fluid measurement element indicating a detection of a leading edge of the blood in the fluid flow pathway, stop the pump to stop the moving of the blood in the pathway, receive a plurality of light intensity measurements from the optical measurement element, each light intensity measurement measured at a corresponding point of time, and provide a mapping of the light intensity measurements into an indication of a coagulation of the blood sample over a time period.