The invention relates to physiological sensor for measurement of carbon dioxide and a method of securing a carbon dioxide permeable membrane of the physiological sensor. The physiological sensor comprising a closed chamber containing a sensor liquid and being bounded, at least partially, by a carbon dioxide permeable membrane (12), at least two electrodes (10) provided within the chamber in contact with the sensor liquid, a support structure (23) for supporting the membrane (12); and at least one filament 28) wound around the support structure (23) and on top of the membrane (12) for securing the gas-permeable membrane (12) to the support structure (23).

A device for assessing changes in erythrocyte deformability, such as erythrocyte sickling tendency in a controlled hypoxic atmosphere, comprising: an at least partially transparent inner wall, an at least partially transparent outer wall extending parallel with the inner wall, wherein a gap is present between the inner and outer walls for receiving a blood sample, wherein one of said walls is movable parallel to and relative to the other one of said walls so as to exert a shear force to the sample in the gap, a light source arranged to emit light in a perpendicular direction through overlapping transparent parts of the inner and outer walls, a camera arranged to observe the light from the light source after it is emitted through said transparent parts of the inner and outer walls in order to detect and assess a diffraction pattern therein when a blood sample is present in said gap and the movable wall is being moved, and an oxygen sensor arranged to be in contact with the blood sample in the gap between the inner and outer walls and to measure the oxygen concentration in the blood sample when the blood sample is present in said gap and the movable wall is being moved. The device is in particular useful for research and development in the field of sickle cell disease and the efficacy of medication and treatments.

A method for assessing an effect of hypoxia on a tissue includes providing a sample of the tissue in a hermetically sealed container, determining a first amount of a reaction substrate (e.g., protocatechuic acid) to be introduced into the sealed container and determining a second amount of a reaction enzyme (e.g., protocatechuate dioxygenase) to be introduced into the sealed container. The method further includes introducing the reaction substrate and the reaction enzyme into the sealed container. At least one of the first amount of the reaction substrate and the second amount of the reaction enzyme is selected to induce at least one of a predetermined amount of hypoxia less than anoxia and a predetermined rate of hypoxia in the tissue during a reaction between the reaction substrate and the reaction enzyme. Values of properties of the tissue can be measured before and after the reaction to assess effects of hypoxia.

The invention discloses a device for identifying fluids or measuring their concentration. The device is configured to capture fluid sensing signals and sent to processing capabilities to be annotated, pre-processed and fed to databases of datasets and models which have learning capabilities. The device has a stick or stylus form factor which is makes it fit to be used by health care professionals or by the general public. Advantageously, the stick can be used to capture data from gas and liquid, being possibly phases of the same analyte. The device can be a package containing all processing capabilities being configured to be autonomous. It can operate in conjunction with an intermediary device of a smart phone, a PC or a POCT type. The system comprising autonomous fluid sensory devices, intermediary devices and database servers can operate in a learning mode or in a use mode. Measurements can be filtered, and normalized to statistically eliminate the differences in measurements due to bad operational conditions, differences of device configurations or differences of local parameters (temperature, hygrometry, flow rate, etc. . . . )

The principles and embodiments of the present disclosure relate to methods for using terlipressin to treat a patient having impaired renal function associated with liver disease. A method of improving kidney function in an adult patient with hepatorenal syndrome with rapid reduction in kidney function may include determining the patient's acute-on-chronic liver failure (ACLF) grade and baseline serum creatinine level; obtaining a baseline oxygenation saturation (SpO.sub.2) of the patient; administering a dose of terlipressin acetate to the patient by intravenous (IV) injection; and monitoring the patient's oxygenation saturation with pulse oximetry.

An optical blood monitoring system and corresponding method avoid the need to obtain a precise intensity value of the light impinging upon the measured blood layer during the analysis. The system is operated to determine at least two optical measurements through blood layers of different thickness but otherwise substantially identical systems. Due to the equivalence of the systems, the two measurements can be compared so that the bulk extinction coefficient of the blood can be calculated based only on the known blood layer thicknesses and the two measurements. Reliable measurements of various blood parameters can thereby be determined without certain calibration steps.

An electrochemical oxygen sensor includes a sensing surface having a working electrode and a reference electrode, a hydrophilic layer formed from an oxygen diffusion-limiting layer emulsion overlaying the working electrode and a hydrophobic membrane formed from a hydrophobic solution disposed over the hydrophilic layer. The hydrophilic layer contains an epoxy network and a hydrophilic polymer. The hydrophobic layer contains an acetate copolymer and a cross-linking agent that reacts with the liquid epoxy resin in the hydrophilic layer forming the epoxy network where the hydrophobic member is water vapor and oxygen permeable.

The present invention relates to a container comprising haemoglobin fractions, wherein said container comprising at least two compartments, wherein a first compartment comprises O2Hb (oxyhaemoglobin) and a second compartment comprises MetHb (methaemoglobin), optionally wherein O2Hb is stabilized. The invention also relates to a kit for determining the reliability of a CO-oximetry device, wherein said kit comprises said container and to a method for determining the reliability of a CO-oximetry device using said container.

A measurement cell (3) for measuring at least one constituent of a liquid sample, in particular blood, includes a reception space (9) for receiving the sample includes a measurement system (8) having at least one sensor electrode (10) exposed within the reception space; a first heat supply equipment (12) extending over a first area (91); a second heat supply equipment (14) extending over a second area (93), the first and second heat supply equipment being arranged to heat the sample within the reception space (9), wherein the second area (93) is larger than the first area (91).

Provided is a photoacoustic imaging device including: a light source unit which generates an ultra-broadband pulsed laser beam and outputs the ultra-broadband pulsed laser beam; a filter unit which filters narrowband pulsed laser beams having predetermined different wavelength bands from the ultra-broadband pulsed laser beam to selectively extract the narrowband pulsed laser beams and outputs the narrowband pulsed laser beams as pulsed laser beams for photoacoustic imaging; and a PA (photoacoustic) unit which receives the pulsed laser beams for photoacoustic imaging to irradiate a measurement object with the pulsed laser beams for photoacoustic imaging and receives photoacoustic signals generated from the measurement object.