The invention provides a physiological sensing device for the measurement of pCO2, the device comprising: (i) a closed chamber bounded, at least partially, by a carbon dioxide permeable membrane; and (ii) at least two electrodes within said chamber, wherein said chamber contains a substantially electrolyte-free liquid in contact with the electrodes and the membrane and wherein the liquid comprises at least one metal or metalloid ion.

The present invention relates to methods for determining a blood gas parameter and/or a basic metabolic panel parameter in a blood sample comprising combining the blood sample with an anti-coagulant and an anti-platelet agent, and determining said blood gas parameter and/or parameter in the sample. In some aspects, the invention relates to determining said parameters in samples that have been subjected to pre-analytical stress.

A method of determining a parameter related to a blood oxygenation of tissue may include projecting an optical pattern onto the issue, the optical pattern comprising a spatially varying component in at least one axis. A method of determining a parameter related to a blood oxygenation of tissue may include collecting a reflected optical signal from at least a first and a second wavelength range, wherein the first and the second wavelength ranges are distinct. A method of determining a parameter related to a blood oxygenation of tissue may include normalizing the reflected optical signal. A method of determining a parameter related to a blood oxygenation of tissue may include performing a transform of the reflected optical signal. A method of determining a parameter related to a blood oxygenation of tissue may include determining the parameter related to the blood oxygenation of the tissue based on the ratio and the transform.

An apparatus for determining the mean corpuscular haemoglobin concentration (MCHC) in a whole blood sample includes a sample holder including an elongate sample chamber having an open end and a closed end. A holding member is adapted to receive and retain the sample holder. The holding member rotates may rotate about an axis of rotation. When the sample holder is received and retained by the holding member the sample chamber is substantially perpendicular to the axis of rotation. First and second light sources are positioned on one side of the sample holder and are configured to emit light in respective different frequencies. At least one light sensor is positioned on a second side of the sample holder, opposite from the first side, so that light from the light source may pass through the sample chamber, in at least one rotational position of the sample holder, and impinge on the light sensor.

A fitment device may include a core made of a first material and including a securing portion configured to secure to a chassis and a container portion configured to seal to a container. The fitment device includes an aperture including a first end located at the securing portion and a second end located at the container portion, wherein the aperture is configured to receive a probe in the first end. A plug located in the aperture is movable within the aperture upon contact with the probe to open a passageway between the first end and an interior of the container. Other devices and methods are disclosed.

The present disclosure refers to a sensor assembly for an IVD analyzer, the sensor comprising two opposite substrates with at least one fluidic conduit for receiving a sample. The electrodes of different types of electrochemical sensors are arranged on the two opposite substrates facing the at least one fluidic conduit for coming in contact with the sample and determining sample parameters, wherein the counter electrodes and the reference electrodes are formed on one substrate and the working electrodes are formed on the opposite substrate. This achieves optimal sensor-working conditions in terms of a homogeneous and symmetrical electric field density and enables a sensor assembly with simpler geometry and smaller size.

The present disclosure refers to a sensor device, a method of operating the sensor device and an IVD analyzer for receiving the sensor device for determining chemical and/or physical characteristics of a fluid. The sensor device comprises at least two fluidic conduits for repeatedly receiving fluids, each fluidic conduit comprising at least one sensory element arranged such as to come in contact with a fluid in the respective fluidic conduit. In particular, the fluidic conduits comprise different sensory elements, respectively, wherein the sensory elements are separated in the respective fluidic conduits according to compatibility or susceptibility to deterioration or operating temperature. Alternately, the fluidic conduits comprise at least in part the same sensory elements, wherein the sensor device is operated in a primary operating mode and in response to a trigger event, switches to an extended operating mode.

Apparatus and methods for response modeling and correction of signals associated with a parameter sensor. In one exemplary embodiment, the parameter sensor is configured to measure a physiologic analyte of a living being (e.g., blood glucose), and the apparatus and methods employ a mathematical transformation of two or more sensing elements (electrodes) of the sensor in order to compensate for temporal response differences or “mismatch.” This compensation enables the calculated blood analyte level, which results from processing of the signals of the two or more sensing electrodes, to be more accurate than calculations made without such compensation. In one variant, the parameter signals are generated, and compensation processing conducted, autonomously via a common implanted sensor platform.

A compound in which a xanthene colorant is bonded to an optical absorber (Dye) with optical absorption in the wavelength range of 350 to 700 nm.

A method and system of responding to adverse environmental conditions local to a user of an oxygen concentrator is disclosed. Physiological data of the user is collected. Operational data of the oxygen concentrator is collected during operation of the oxygen concentrator. Environment data local to the oxygen concentrator is collected. Based on the collected environmental data, it is determined whether adverse environmental conditions exist local to the oxygen concentrator. The collected physiological, operational, and environmental data are analyzed to determine a responsive action to the determined adverse environmental conditions. The responsive action is communicated to the user.