The present system and method are useful for the removal of immune inhibitors such as soluble TNF receptors from the body fluid of cancer patients. In some embodiments, soluble TNF-Receptors 1 and 2 are selectively removed from plasma at 80% or more efficiency. In some embodiments, the system includes an immobilized capture ligand of a single chain TNFα. The system and method are useful for the treatment of different cancer types, stages and severity.

Some embodiments of the disclosure provide a time-resolved fluorescent immunochromatographic test strip for detecting paclitaxel drugs as well as a preparation method and application thereof. In some embodiments, the test strip includes a test paper and a sample diluent. The test paper includes a bottom plate, a sample absorption pad, a fluorescent microsphere pad, a bonding pad, and an absorbent pad. The sample absorption pad, the fluorescent microsphere pad, the bonding pad, and the absorbent pad are sequentially overlapped on the bottom plate. The fluorescent microsphere pad is sprayed with a fluorescent microsphere-labeled anti-paclitaxel monoclonal antibody. A detection area and a quality control area are immobilized on the bonding pad. The detection area is sprayed with a paclitaxel hapten-carrier protein conjugate. The quality control area is sprayed with a goat anti mouse antibody.

The present invention relates to a fluid flow device. The device includes an elongate body having a proximal end, a distal end, and a length therebetween, at least one source fluid inflow port, at least one waste fluid outflow port, at least one well inlet port positioned at the distal end of the elongate body, at least one well outlet port positioned at the distal end of the elongate body, at least one conduit connecting the at least one source fluid inflow port to the at least one well inlet port, and at least one conduit connecting the at least one waste fluid outflow port to the at least one well outlet port.

Systems and methods for improved measurement of absorbance/transmission through fluidic systems are described. Specifically, in one set of embodiments, optical elements are fabricated on one side of a transparent fluidic device opposite a series of fluidic channels. The optical elements may guide incident light passing through the device such that most of the light is dispersed away from specific areas of the device, such as intervening portions between the fluidic channels. By decreasing the amount of light incident upon these intervening portions, the amount of noise in the detection signal can be decreased when using certain optical detection systems.

Disclosed are devices and methods for detecting analytes from a sample.

A test device having a micro flow channel including a reaction part where a reactant that is reactive to a tested chemical dispersed in a tested fluid is fixed, and at least one actuator for actuating the tested fluid to move in at least one of two opposite sides of the micro flow channel so as to homogenize a density distribution of the tested chemical in the tested fluid. The tested fluid is sent in the micro flow channel a plurality of times.

The present invention provides an analyte detection system for detecting target analytes in a sample. In particular, the invention provides a detection system in a rotor or disc format that utilizes a centrifugal force to move the sample through the detection system. Methods of using the rotor detection system to detect analytes in samples, particularly biological samples, and kits comprising the rotor detection system are also disclosed.

According to an aspect, a server receives first and second transient (changing with time) locations of an entity, the first transient location being associated with a time instance until which the entity is physically present at the first transient location. The server accordingly provides the first transient location as the physical location of the entity prior to the time instance, and the second transient location as the physical location after the time instance. According to another aspect, a client device identifies that a search text (received from a user) is directed to searching for physical locations in view of the search text including an affix. The client device then parses the search text to determine an identifier, sends a location request containing the identifier, receives a response containing a transient location associated with the identifier, and then provides the transient location to the user as the response to the search.

The present invention relates to fluidic devices for preparing, processing, storing, preserving, and/or analyzing samples. In particular, the devices and related systems and methods allow for preservation or storage of samples (e.g., biospecimen samples) by using one or more of a bridge, a membrane, and/or a desiccant.

The invention is to devices and method for rapid determination of analytes in liquid samples by various assays including immunoassays incorporating a sample dilution feature for forming a diluted sample for analysis. The devices and methods also include a dilution verification feature for verifying the degree of dilution of the diluted sample. The devices preferably are capable of being used in the point-of-care diagnostic field is provided.