A sample analysis device includes: a motor to rotate a sample analysis substrate with a sample introduced thereon around a rotation axis of the sample analysis substrate; a drive circuit to drive the motor; a photodetector to measure a number of photons associated with a luminescence from the sample being transmitted through a window of a measurement chamber of the sample analysis substrate; and a control circuit to calculate a measurement value of the luminescence of the sample by using a number of photons measured by the photodetector while the motor rotates the sample analysis substrate.

Disclosed herein are chips, devices, methods of making the same, and methods of detecting a target analyte, and methods of diagnosing an individual with a disease or condition when a target analyte associated with the disease or condition is detected.

This disclosure relates to soluble β-glucan immunotherapies that affect the tumor microenvironment. The soluble β-glucan immunotherapies promote an immunostimulatory environment, which enhances the effectiveness of the combination of anti-angiogenics and checkpoint inhibitors.

An automatic and continuous glucose monitoring apparatus and method of using same based on binding proteins. The apparatus integrates an aseptic sampling technique, a specially modified chromatography column to hold immobilized binding protein, and a microfluorometer into a compact portable device. The apparatus permits the measurement of a very wide range of concentrations—from a few micromolar to several hundreds of millimolar of glucose.

The present invention relates to a microfluidic connection device for enabling faster observation of reactions even with only sample amount far less than that of reaction experiments in which a 96-well particularly used for a conventional sample reaction is used. The objective of the present invention is to provide the microfluidic connection device comprising: a microtube having a fine tube shape; a microvalve comprising a fluid moving unit for causing samples filled in the microtube to flow or stop; a plate-shaped plate; a reaction zone in which chemical reactions between samples supplied through the microtube occur, which has an observation window through which chemical reactions are observed, and which is provided on the upper surface of the plate; a supply tube for connecting the reaction zone with the microtube; and a reaction plate comprising a discharge tube for discharging reactants from the reaction zone.

The present disclosure provides an improved field effect transistor and device that can be used to sense and characterize a variety of materials. The field effect transistor and/or device including the transistor may be used for a variety of applications, including genome sequencing, protein sequencing, biomolecular sequencing, and detection of ions, molecules, chemicals, biomolecules, metal atoms, polymers, nanoparticles and the like.

The invention relates to systems and methods for the determination of degree and distribution of pectin homogalacturonan (HG) methyl-esterification. The systems comprise a sheet, at least one labeled anti-pectin detection antibody, and a Template Guide. The sheet may comprise an absorbent portion and a membrane portion; an absorbent portion, a membrane portion, and a conjugate portion; or an absorbent portion, a membrane portion, a conjugate portion, and a sample portion. The membrane portion comprises a Control Zone with at least one immobilized unlabeled capture reagent and a Test Zone with at least one immobilized unlabeled anti-pectin capture antibody. When the sheet comprises a conjugate portion, the at least one labeled anti-pectin detection antibody is on the conjugate portion. The system may optionally comprise a container with the at least one labeled anti-pectin detection antibody.

The present invention relates to an assay device for determining the presence and/or amount of an analyte of interest in a sample, the assay device comprising: a) a housing that includes a liquid receiving unit that is adapted to accommodate one or more types of liquid; b) a mixing chamber adapted for containing a solution that is a product of one more types of liquid, and for receiving a sample to interact with said solution; c) an actuating lid which is capable of being actuated to enable the transfer of the liquid into the mixing chamber; and d) an assay means that is in fluid communication with said mixing chamber for determining the presence and/or amount of an analyte of interest in the sample after the interaction of said sample with said solution in the mixing chamber.

The present invention provides assays and assay systems for use in spatially encoded biological assays. The invention provides an assay system comprising an assay capable of high levels of multiplexing where reagents are provided to a biological sample in defined spatial patterns; instrumentation capable of controlled delivery of reagents according to the spatial patterns; and a decoding scheme providing a readout that is digital in nature.

Embodiments of the present disclosure provide a target capturing apparatus and a manufacturing method thereof, and a target detecting method. The target capturing apparatus includes a cavity structure, the cavity structure includes: an inlet portion, an outlet portion and a capture region positioned between the inlet portion and the outlet portion, and the capture region includes a capture component, and a combination specifically combined with a to-be-captured target is included in the capture component so as to capture the target in a sample entering the cavity structure.