Provided are methods for biological sample processing and analysis. A method can comprise providing a substrate configured to rotate. The substrate can comprise an array having immobilized thereto a biological analyte. A solution comprising a plurality of probes may be directed, via centrifugal force, across the substrate during rotation of the substrate, to couple at least one of the plurality of probes with the biological analyte. A detector can be configured to detect a signal from the at least one probe coupled to the biological analyte, thereby analyzing the biological analyte.

Aspects of the disclosure relate to methods and compositions (e.g., kits) for detecting anti-repeat-associated non-ATG (RAN) protein antibodies in a subject (e.g., a subject that has been administered a therapeutic anti-RAN protein antibody or a vaccine against a disease or disorder associated with RAN protein expression, translation, and/or accumulation, for example amyotrophic lateral sclerosis (ALS) and/or frontotemporal dementia (FTD)). In some embodiments, methods described by the disclosure comprise detecting one or more anti-RAN protein antibodies in a biological sample obtained from a subject by an electrochemiluminescence-based immunoassay using one or more target di-amino acid repeat peptides. In some embodiments, the disclosure relates to kits comprising one or more di-amino acid repeat peptides and an electrochemiluminescence-based immunoassay plate and/or reagents.

Devices and methods for immunomagnetic separation having a flexible inflatable processing chamber and magnetic array.

The present invention relates to a biosensor technique in which multiple types of target substances (biomarkers) contained in saliva or the like are allowed to be simultaneously measured or N samples for one target substance (biomarker) are allowed to be simultaneously measured and reliability of sensed results and high sensitivity are secured. A fluidic channel-based planar biosensor chip, in which a plurality of fluidic channels capable of measuring target substances (biomarkers) are embedded in one flat plate sensor chip and the flat plate sensor chip is measured by a light-emitting element (optical source) and a light-receiving element, and a biomarker measuring apparatus using the same are provided.

An elongated incubation trough has an indentation open toward a top end as well as a bottom. The indentation has a first receiving area to receive an elongated test strip as well as a second receiving area to receive an end section of a fluid line. The second receiving area is in fluidic communication with the first receiving area. A maximum width of the second receiving area at bottom height is greater than a maximum width of the first receiving area at bottom height.

Various systems, devices, components, and methods are disclosed for measuring the concentration of an analyte, such as acetone, in a breath sample. The disclosed devices include a breath sample analysis device having a mouthpiece configured to facilitate engagement with a user's mouth to receive a breath sample. The disclosed devices also include a breath sample capture cartridge containing an interactant that extracts the analyte from a breath sample passed through the cartridge. Also disclosed are devices for routing the breath sample through the cartridge during exhalation, and for analyzing a reaction in the cartridge to measure a concentration of the analyte.

Disclosed herein are formulations, substrates, and arrays. Also disclosed herein are methods for manufacturing and using the formulations, substrates, and arrays. Also disclosed are methods for identifying peptide sequences useful for diagnosis and treatment of disorders, and methods for using the peptide sequences for diagnosis and treatment of disorders, e.g., celiac disorder. In certain embodiments, substrates and arrays comprise a porous layer for synthesis and attachment of polymers or biomolecules.

The embodiments disclosed herein provide a peptoid, which is a compound of Formula I or a stereoisomer, a mixture of stereoisomers, or a pharmaceutically acceptable salt thereof. N—R.sub.4, N—R.sub.3, N—R.sub.2, and N—R.sub.1 in Formula I are

##STR00001##

respectively. The peptoid has a strong binding ability with an EpCAM protein. It can be used as molecular probes for diseases associated with an EpCAM protein, to achieve targeted therapy, in vivo imaging diagnosis and prognosis monitoring of the diseases associated with the EpCAM protein at low cost, high accuracy and high efficiency.

##STR00002##

The subject of the invention is a bioreceptor molecule with the formula: R.sub.1-alkyl-C(0)NH—R.sub.2, wherein alkyl is linear or branched alkyl with 2 to 20 C atoms; R.sub.1 is selected from a group comprising thiol group (—SH); disulfide bridge; —S(O)-alkyl, wherein alkyl is linear or branched and contains 1-3 C atoms; thioether, wherein thioether contains 1-3 C atoms; thioacid; thionyl group; R.sub.2 is a peptide with a sequence selected from a group comprising SEQ ID NO 1-8. Another subject of the invention is the use of bioreceptor molecules according to the invention in electrochemical impedance spectroscopy for detecting the SARS-CoV-2 virus. The subject of the invention is also a sensor containing an electrode, whose surface is covered with a layer of metal, characterized in that this layer is modified by bioreceptor molecules according to the invention. Furthermore, the subject of the invention is the method of detecting the SARS-Cov-2 virus by means of electrochemical impedance spectroscopy, including the following steps: a. rinsing and drying of the sensor electrode covered with metal; b. modification of the sensor electrode surface with bioreceptor molecules; c. calibration of the measurement system; d. detection of SARS-Cov-2 virus in a sample by means of a measurement system by observation of impedance changes, characterized in that surface modification of the sensor electrode is carried out using bioreceptor molecules according to the invention, wherein the presence of the virus in the test sample is indicated by a change in impedance of at least 10% in absolute value against the baseline value.

Devices, methods, and kits for detecting at least two analytes present within a small volume single fluid sample obtained from patient for the creation of a multiplexed panel of the various analytes present within the single fluid sample are disclosed.