Provided are compositions and methods for delivering biological moieties such as modified nucleic acids into cells to modulate protein expression. Such compositions and methods include the use of modified messenger RNAs, and are useful for production of proteins.

A glucometer having a media slot for receiving a test medium, a media reader having a sensor sensitive to a glucose level of a blood sample disposed on the test medium when introduced into the media slot, a one-way outbound communication channel, a processing unit for executing instructions stored on a computer memory element, including instructions to detect the test medium inside the media slot, operate the media reader, analyze the media reader results, generate the blood sample glucose level, produce digital data representing the blood sample glucose level, and transmit the digital data via the one-way outbound communication channel to a remote computing device, where the glucomter lacks an inbound communication channel that supports transmission from the remote computing device to the glucometer.

A glucometer having a media slot for receiving a test medium, a media reader having a sensor sensitive to a glucose level of a blood sample disposed on the test medium when introduced into the media slot, a one-way outbound communication channel, a processing unit for executing instructions stored on a computer memory element, including instructions to detect the test medium inside the media slot, operate the media reader, analyze the media reader results, generate the blood sample glucose level, produce digital data representing the blood sample glucose level, and transmit the digital data via the one-way outbound communication channel to a remote computing device, where the glucomter lacks an inbound communication channel that supports transmission from the remote computing device to the glucometer.

The present invention includes influenza Hemagglutinin protein fragments that fold properly when expressed in bacteria.

The present invention includes influenza Hemagglutinin protein fragments that fold properly when expressed in bacteria.

A method for measuring a glucose level of a blood sample by detecting the test medium inside a media slot of a glucometer, reading the test medium inside said media slot, analyzing a result of the reading, generating the glucose level of a blood sample disposed on the test medium, producing digital data representing the glucose level of the blood sample, encoding the digital data within an audio signal; and wirelessly and repeatedly transmitting the digital data until the test medium is removed.

A method for measuring a glucose level of a blood sample by detecting the test medium inside a media slot of a glucometer, reading the test medium inside said media slot, analyzing a result of the reading, generating the glucose level of a blood sample disposed on the test medium, producing digital data representing the glucose level of the blood sample, encoding the digital data within an audio signal; and wirelessly and repeatedly transmitting the digital data until the test medium is removed.

Apparatus for performing an assay to detect the presence of an analyte in a test sample. A housing defines a slot for receiving a sample collector, and a capsule contains a buffer liquid, the capsule being sealed by an openable lid, and being connected to the housing such that insertion of a sample collector into the slot causes the lid to open releasing the buffer liquid into the slot. The housing further defines an incubation chamber containing or configured to receive a reagent, and an aperture permitting liquid communication between the slot and the incubation chamber. The apparatus comprises one or more test elements, a substantially liquid tight sealing member separating the incubation chamber and the test element(s), and an activation mechanism operable to open the liquid tight sealing member thereby bringing at least a portion of the or each test element into liquid communication with the incubation chamber.

Apparatus for performing an assay to detect the presence of an analyte in a test sample. A housing defines a slot for receiving a sample collector, and a capsule contains a buffer liquid, the capsule being sealed by an openable lid, and being connected to the housing such that insertion of a sample collector into the slot causes the lid to open releasing the buffer liquid into the slot. The housing further defines an incubation chamber containing or configured to receive a reagent, and an aperture permitting liquid communication between the slot and the incubation chamber. The apparatus comprises one or more test elements, a substantially liquid tight sealing member separating the incubation chamber and the test element(s), and an activation mechanism operable to open the liquid tight sealing member thereby bringing at least a portion of the or each test element into liquid communication with the incubation chamber.

A method for measuring a glucose level of a blood sample by detecting the test medium inside a media slot of a glucometer, reading the test medium inside said media slot, analyzing a result of the reading, generating the glucose level of a blood sample disposed on the test medium, producing digital data representing the glucose level of the blood sample, encoding the digital data within an audio signal; and wirelessly and repeatedly transmitting the digital data until the test medium is removed.