The present disclosure relates to anti-human cytomegalovirus (anti-HCMV) antibodies and vaccines as well as diagnostic and therapeutic methods of use.

The present invention comprises methods and systems that use acoustic radiation pressure.

This disclosure describes, in one aspect, a method for identifying β-glucan binding to immune cells of a subject. Generally, the method includes obtaining a blood sample from the subject, the blood sample comprising immune cells, adding soluble β-glucan to at least a portion of the blood sample and incubating the mixture under conditions allowing the soluble β-glucan to bind to the immune cells, and detecting soluble β-glucan bound to the immune cells. In another aspect, this disclosure describes a method that generally includes identifying the subject as a low binder of β-glucan, and co-administering to the subject a soluble β-glucan and an antibody preparation capable of converting the subject from a low binder to a high binder.

Embodiments of the present disclosure provide a target capturing apparatus and a manufacturing method thereof, and a target detecting method. The target capturing apparatus includes a cavity structure, the cavity structure includes: an inlet portion, an outlet portion and a capture region positioned between the inlet portion and the outlet portion, and the capture region includes a capture component, and a combination specifically combined with a to-be-captured target is included in the capture component so as to capture the target in a sample entering the cavity structure.

A method of diagnosing a CD206 expressing cell-related disorder by administering a pharmaceutical composition to a subject, the composition including a carrier molecule having a detectable moiety attached thereto. The carrier molecule has a dextran backbone, and at least one receptor substrate conjugated, directly or indirectly, to the dextran backbone, wherein the receptor substrate is chosen so as to specifically bind to CD206. A method of treating a CD206 expressing cell-related disorder is also provided, as well as an ex vivo method and kit for quantitating the number of cells expressing CD206 in a bodily fluid.

Embodiments of the present disclosure are directed to systems, devices, and methods for the selective collection of cells from a heterogeneous cell population, including highly multiplexed detection of secreted and intracellular macromolecules and the targeted laser-assisted ablation of cells identified to be positive or negative for a given biomarker or phenotype. The resulting non-ablated cells can be collected individually or pooled to form a homogenous cell population for further processing including safe and efficacious cellular therapies.

The present invention provides for methods of identifying cell types and cell subtypes from a biological sample or population of target cells. The methods further provide for determining cell type or cell subtype signatures. The method further provides for bipolar cell subtypes and markers and cell signatures thereof.

Control compositions and methods of making the same are provided. Aspects of the control compositions include a first white blood cellular component including one or more positive control markers for white blood cells; a second cellular component including one or more positive control markers for hematopoietic stem/progenitor cells; and a third cellular component including one or more positive control markers for neoplastic cells, wherein the first white blood cellular component, the second cellular component, and third cellular component are fixed. Also provided are methods for using the control compositions as positive controls, e.g., in a flow cytometric assay, as well as kits for practicing the subject methods.

A problem to be solved is to provide an immunochromatographic test strip in which a specimen sufficiently and quickly permeates into a sample application region within a test time so that variations in detection values of a test line can be prevented. Particularly, a problem to be solved is to provide an immunochromatographic test strip causing less variations in detection values even when the specimen is whole blood.

The problems are solved by providing an immunochromatographic test strip including at least a sample application region, a development region, and a detection region, wherein the sample application region contains polyethylene glycol having a molecular weight of 15,000 to 700,000.

The invention relates to senescent cell biomarkers and the uses thereof. The invention also extends to methods and kits for detecting senescence, and drug conjugates and pharmaceutical compositions for killing senescent cells.