A method and a system of detecting, identifying and quantifying an analyte, for example coronavirus, in a specimen comprising, comprising: apportioning the suspended specimen into one or more test samples; optionally adding a reagent to the test samples; and applying an electric field with a first magnitude and with a second magnitude over the test samples for a selected period of time. The second magnitude should be higher than the first magnitude. The method and system further comprises: measuring electrical properties of said one or more test samples in response to said applied electric field for said first magnitude and for said second magnitude over said period of time; identifying characteristics of said electrical properties responses; and determining the presence, the identification and/or the quantity of coronavirus based on the characteristics of said electrical properties responses to said first magnitude and to said second magnitude of the applied electric field.

A system for detecting COVID-19 infection, including a colorimetric sensor, an image-capturing device, and a processing unit. The colorimetric sensor includes an array of chemical receptors configured to be exposed to exhaled breath of a person suspected to be infected by COVID-19 virus. The array of chemical receptors includes an array of metalloporphyrazines, an array of organic dyes, an array of metalloporphyrins, an array of metal ion complexes, and an array of functionalized gold nanoparticles (AuNPs). The processing unit is configured to perform a method utilizing the image-capturing device. The method includes capturing a first image from the array of chemical receptors before exposure to exhaled breath, capturing a second image from the array of chemical receptors after exposure to exhaled breath, and detecting COVID-19 infection status of the person by analyzing color changes of the array of chemical receptors in the second image respective to the first image.

Disclosed are methods, devices and systems for the isolation and detection of biomolecules from a sample. The embodiments, detection of such biomolecules provides for detection of microorganisms. For example, disclosed are methods, devices and systems that use bacteriophage-based amplification of the signal in detection of bacteria and other microorganisms. The devices, systems and methods of the invention may allow for the detection of certain biomolecules peptides and ions in real time using minute amounts of sample.

A method of analyzing biological data containing expression values of a plurality of polypeptides in the blood of a subject. The method comprises: calculating a distance between a segment of a curved line and an axis defined by a direction, the distance being calculated at a point over the curved line defined by a coordinate along the direction. The method further comprises correlating the distance to the presence of, absence of, or likelihood that the subject has, a bacterial infection. The coordinate is defined by a combination of the expression values, wherein at least 90% of the segment is between a lower bound line and an upper bound line.

A method for reducing electrode gap distances in an electronic device having a first electrode spatially separated from a second electrode by an electrode gap can comprise selecting (810) a milometer gap size to bind a biological material based on a size of the biological material and binding effects with the biological material. The method can further comprise coating (820) at least one surface of an electrode gap region with a first layer including molecular recognition groups, and coating (830) the at least one surface with a second layer including electrically-conductive solids that are configured to bond with the molecular recognition groups. The electronic device can be further coated (840) with additional alternating layers of the molecular recognition groups and the electrically-conductive solids to reach the nanometer gap size between a first electrode and a second electrode of the electronic device.

A method includes attaching two or more beads to each unit of one or more units of a chemical component in a sample, to form, for each unit of the chemical component, a multi-bead complex including two or more beads and the unit of the chemical component; placing the sample on a surface of an image sensor; at the image sensor, receiving light originating at a light source, the received light including light reflected by, refracted by, or transmitted through the beads of the multi-bead complexes; at the image sensor, capturing one or more images of the sample from the received light; and identifying, in at least one of the images of the sample, separate multi-bead complexes, the identifying of the separate multi-bead complexes including associating the two or more beads of each of the multi-bead complexes based on proximity to one another.

The invention relates to methods and reagents for analyzing samples for the presence of JC virus antibodies.

Embodiments described herein generally relate to: sensing and/or authentication using luminescence imaging; diagnostic assays, systems, and related methods; temporal thermal sensing and related methods; and/or to emissive species, such as those excitable by white light, and related systems and methods.

A system for detecting COVID-19 infection, including a colorimetric sensor, an image-capturing device, and a processing unit connected to the image-capturing device. The colorimetric sensor includes an injection zone and a detection zone patterned on a paper, where the injection zone covers the detection zone by folding the paper. The injection zone is configured to inject a saliva sample acquired from a person thereon. The detection zone includes an array of chemical receptors configured to interact with the injected saliva penetrating into the detection zone. The processing unit is configured to perform a method of capturing a first image from the detection zone before injection of the saliva sample, capturing a second image from the detection zone after injection of the saliva sample, and detecting COVID-19 infection status of the person by analyzing color changes of the array of chemical receptors in the second image respective to the first image.

The invention provides broadly neutralizing antibodies directed to epitopes of Human Immunodeficiency Virus, or HIV. The invention further provides compositions containing HIV antibodies used for prophylaxis, and methods for diagnosis and treatment of HIV infection.